{"id":48801,"date":"2020-08-18T14:45:00","date_gmt":"2020-08-18T11:45:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/unraveling-the-initial-molecular-events-of-respiration\/"},"modified":"2020-08-18T14:45:00","modified_gmt":"2020-08-18T11:45:00","slug":"unraveling-the-initial-molecular-events-of-respiration","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/unraveling-the-initial-molecular-events-of-respiration\/","title":{"rendered":"#Unraveling the initial molecular events of respiration"},"content":{"rendered":"

“#Unraveling the initial molecular events of respiration<\/strong>”<\/p>\n

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Respiration is a fundamental process of all living things, allowing them to produce energy, stay healthy, and survive. In cells, respiration involves what are known as “respiratory proteins,” e.g. hemoglobin in the blood and myoglobin in muscles.<\/p>\n

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Respiratory proteins work by binding and releasing small molecules like oxygen, carbon monoxide etc., called ligands. They do this through their “active center,” which in many respiratory proteins is a chemical structure called heme porphyrin.<\/p>\n

Binding and releasing small molecules causes changes in the heme’s molecular and electronic structure. Such a change is the transition from a planar low spin ligated porphyrin form to a domed high spin un-ligated form and vice-versa. This shift is a key step for respiration, ultimately switching hemoglobin between a “relaxed” and “tense” conformation.
\nElectrons spin around atoms, but also spin around themselves, and can cross over from one spin state to another. The debate about the transition from low-spin planar to a high-spin domed heme has been dominated by two schools of thought: the process is either by thermal relaxation or by a cascade among electron spin states.
\nNow, a team of scientists led by Majed Chergui at EPFL’s School of Basic Science<\/a>s have solved the debate. The researchers detached the small molecule from the heme using short, energizing laser pulses. They then used another short, hard X-ray pulse from an X-ray free-electron laser to induce X-ray emission (XES), a very sensitive fingerprint of the spin state of molecules, which monitored the heme’s changes as a function of time. They could thus determine that the passage from planar to domed and back is caused by a cascade among spin states.
\nThe study was carried out on nitrosyl-myoglobin, which is myoglobin that has bound a nitric oxide molecule. Nitrosyl-myoglobin plays a crucial role in neurotransmission, regulation of vasodilatation, platelet aggregation, and immune responses.
\n“The conclusions of our work app<\/a>ly to all heme proteins,” says Chergui. “In particular to hemoglobin in its uptake and release of oxygen when we breathe. Although this takes place at the thermal temperatures of the body, breathing is governed by electronic changes in the heme.”<\/p>\n

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More information:<\/strong>
\n Femtosecond X-ray emission study of the spin cross-over dynamics in heme proteins. Nature Communications<\/i> DOI: 10.1038\/s41467-020-17923-w\n <\/div>\n

\n Citation<\/strong>:
\n Unraveling the initial molecular events of respiration (2020, August 18)
\n retrieved 18 August 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-08-unraveling-molecular-events-respiration.html<\/p>\n

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“#Unraveling the initial molecular events of respiration” Credit: CC0 Public Domain Respiration is a fundamental process of all living things, allowing them to produce energy, stay healthy, and survive. In cells, respiration involves what are known as “respiratory proteins,” e.g. hemoglobin in the blood and myoglobin in muscles. Respiratory proteins work by binding and releasing…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[10670,54935],"class_list":["post-48801","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-cell-microbiology","tag-unraveling-the-initial-molecular-events-of-respiration"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/48801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=48801"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/48801\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=48801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=48801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=48801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}