{"id":49875,"date":"2020-08-19T19:19:00","date_gmt":"2020-08-19T16:19:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/toward-a-coronavirus-breathalyzer-test\/"},"modified":"2020-08-19T19:19:00","modified_gmt":"2020-08-19T16:19:00","slug":"toward-a-coronavirus-breathalyzer-test","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/toward-a-coronavirus-breathalyzer-test\/","title":{"rendered":"#Toward a coronavirus breathalyzer test"},"content":{"rendered":"

“#Toward a coronavirus breathalyzer test<\/strong>”<\/p>\n

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\"covid-19\"<\/img>
\n Credit: CC0 Public Domain
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Few people who have undergone nasopharyngeal swabs for coronavirus testing would describe it as a pleasant experience. The procedure involves sticking a long swab up the nose to collect a sample from the back of the nose and throat, which is then analyzed for SARS-CoV-2 RNA by the reverse-transcript<\/a>ion polymerase chain reaction (RT-PCR). Now, researchers reporting in ACS Nano<\/i> have developed a prototype device that non-invasively detected COVID-19 in the exhaled breath of infected patients.<\/p>\n

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In addition to being uncomfortable, the current gold standard for COVID-19 testing requires RT-PCR, a time-consuming laboratory procedure. Because of backlogs, obtaining a result can take several days. To reduce transmission and mortality rates, healthcare systems need quick, inexpensive and easy-to-use tests. Hossam Haick, Hu Liu, Yueyin Pan and colleagues wanted to develop a nanomaterial-based sensor that could detect COVID-19 in exhaled breath, similar to a breathalyzer test for alcohol intoxication. Previous studies have shown that viruses and the cells they infect emit volatile organic compounds (VOCs) that can be exhaled in the breath.<\/p>\n

The researchers made an array of gold nanoparticles linked to molecules that are sensitive to various VOCs. When VOCs interact with the molecules on a nanoparticle, the electrical resistance changes. The researchers trained the sensor to detect COVID-19 by using machine learning to compare the pattern of electrical resistance signals obtained from the breath of 49 confirmed COVID-19 patients with those from 58 healthy controls and 33 non-COVID lung infection patients in Wuhan, China. Each study participant blew into the device for 2-3 seconds from a distance of 1-2 cm. Once machine learning identified a potential COVID-19 signature, the team tested the accuracy of the device on a subset of participants. In the test set, the device showed 76% accuracy in distinguishing COVID-19 cases from controls and 95% accuracy in discriminating COVID-19 cases from lung infections. The sensor could also distinguish, with 88% accuracy, between sick and recovered COVID-19 patients. Although the test needs to be validated in more patients, it could be useful for screening large populations to determine which individuals need further testing, the researchers say.<\/p>\n

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More information:<\/strong>
\n Benjie Shan et al. Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath, ACS Nano<\/i> (2020). DOI: 10.1021\/acsnano.0c05657\n <\/div>\n

\n Citation<\/strong>:
\n Toward a coronavirus breathalyzer test (2020, August 19)
\n retrieved 19 August 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-08-coronavirus-breathalyzer.html<\/p>\n

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“#Toward a coronavirus breathalyzer test” Credit: CC0 Public Domain Few people who have undergone nasopharyngeal swabs for coronavirus testing would describe it as a pleasant experience. The procedure involves sticking a long swab up the nose to collect a sample from the back of the nose and throat, which is then analyzed for SARS-CoV-2 RNA…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[18279,55723],"class_list":["post-49875","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-bio-medicine","tag-toward-a-coronavirus-breathalyzer-test"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/49875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=49875"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/49875\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=49875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=49875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=49875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}