{"id":502534,"date":"2022-10-21T08:46:26","date_gmt":"2022-10-21T05:46:26","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/deep-fake-protein-designed-with-artificial-intelligence-will-target-water-pollutants\/"},"modified":"2022-10-21T08:46:26","modified_gmt":"2022-10-21T05:46:26","slug":"deep-fake-protein-designed-with-artificial-intelligence-will-target-water-pollutants","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/deep-fake-protein-designed-with-artificial-intelligence-will-target-water-pollutants\/","title":{"rendered":"#&#8217;Deep fake&#8217; protein designed with artificial intelligence will target water pollutants"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2f20d7c8ebc\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2f20d7c8ebc\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/deep-fake-protein-designed-with-artificial-intelligence-will-target-water-pollutants\/#%E2%80%9C%E2%80%98Deep_fake_protein_designed_with_artificial_intelligence_will_target_water_pollutants%E2%80%9D\" >&#8220;&#8216;Deep fake&#8217; protein designed with artificial intelligence will target water pollutants&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9C%E2%80%98Deep_fake_protein_designed_with_artificial_intelligence_will_target_water_pollutants%E2%80%9D\"><\/span>&#8220;&#8216;Deep fake&#8217; protein designed with artificial intelligence will target water pollutants&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/deep-fake-protein-desi.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/deep-fake-protein-desi.jpg\" data-sub-html=\"A University of Kansas researcher will use machine learning to create \u201cdeep-fake\u201d membrane beta-barrel proteins \u2014 a class of naturally successful biosensors \u2014 designed to detect polluting metal ions in water. Credit: T. Chris Gamblin\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/deep-fake-protein-desi.jpg\" alt=\"'Deep fake' protein designed with artificial intelligence will target water pollutants\" title=\"A University of Kansas researcher will use machine learning to create \u201cdeep-fake\u201d membrane beta-barrel proteins \u2014 a class of naturally successful biosensors \u2014 designed to detect polluting metal ions in water. Credit: T. Chris Gamblin\" width=\"700\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                A University of Kansas researcher will use machine learning to create \u201cdeep-fake\u201d membrane beta-barrel proteins \u2014 a class of naturally successful biosensors \u2014 designed to detect polluting metal ions in water. Credit: T. Chris Gamblin<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>If you&#8217;ve ever used a text-based artificial-intelligence image generator like Craiyon or DALL-E, you know with a few word prompts that the AI tools create images that are both realistic and completely synthesized.<\/p>\n<p>                                                                                The machine learning that powers such websites will scan millions of images on the internet, analyze them and assemble facets of them into fresh, but fake, images.<\/p>\n<p>Now, University of Kansas researchers are working to use a similar machine-learning process to build new proteins designed to detect water pollutants. A KU researcher plans to use machine learning to create &#8220;deep-fake&#8221; membrane beta-barrel proteins\u2014a class of naturally successful biosensors\u2014designed to detect polluting metal ions in water.<\/p>\n<p>&#8220;These beta barrels are super useful because they can bring things across membranes,&#8221; said principal investigator Joanna Slusky, associate professor of molecular bio<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>s at KU. &#8220;Barrels make good enzymes\u2014there are so many different things that barrels can do.&#8221;<\/p>\n<p>Previous research on the tube-like beta barrels has altered their binding properties for a variety of tasks. However, much of this work was arduous and completed by hand, usually resulting with minor variations of a limited number of scaffolds, or barrel structures.<\/p>\n<p>&#8220;In this case, we&#8217;re using machine learning to generate large numbers of barrels,&#8221; Slusky said. &#8220;But, how about if we can both generate barrels and have them be useful? We asked ourselves, &#8216;What&#8217;s a bio<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lication of barrels?&#8217; Well, one would be metal sensors that could perhaps detect metal pollutants.&#8221;<\/p>\n<p>Slusky and her co-principal investigators, professors Rachel Kolodny and Margarita Osadchy of Haifa University in Israel (along with KU postdoctoral fellow Daniel Montezano), will develop a new machine-learning process that generates beta-barrels with scaffolds similar to those found in nature, but with different sequences.<\/p>\n<p>&#8220;There&#8217;s a website called &#8216;This X Does Not Exist,'&#8221; Slusky said. &#8220;If you go to that site, you see all these AI-generated things and people don&#8217;t really exist. But a computer made an image, for instance, of a cat. But that&#8217;s not really a cat\u2014a computer took a bunch of pictures of cats and said, &#8216;OK, we can just sort of generate as many cat pictures as you want now, because we figured out what is a cat.&#8217; We need to make something real so we see it more like generating a recipe.&#8221;<\/p>\n<p>&#8220;The question is, how to make computers generate a recipe for proteins.&#8221;<\/p>\n<p>Beta barrels are well-suited to advancement through machine learning because &#8220;natural proteins are sort of a small blip in the number of possible sequences.&#8221;<\/p>\n<p>If a computer algorithm can learn the essence of what makes a protein a protein, Slusky said, it will avoid generating useless sequences.<\/p>\n<p>&#8220;Most sequences would never actually be proteins\u2014 they wouldn&#8217;t have a particular fold,&#8221; she said. &#8220;They would just kind of bond with themselves in weird, nonpredictable ways over and over again. To be a protein, you need a sequence that makes one shape. When people tried to make random sequences, or even somewhat directed sequences, they found that only a very, very small percentage of them might actually be a protein.&#8221;<\/p>\n<p>With machine learning creating new and viable sequences resulting in this common fold, Slusky and her colleagues hope to generate a beta-barrel especially well-suited to finding metal ions in water. This result of the work will be biosensors based on beta barrels that can identify pollutants like lead in waterways.<\/p>\n<p>&#8220;If we make them the right size, this molecule will be ideal to put some particular metal in, and you can have the right substituents so that it would bind that metal,&#8221; Slusky said. &#8220;Because it&#8217;s in a membrane, it can give you some sort of conductance difference\u2014there&#8217;s a difference between when it&#8217;s bound and when it&#8217;s not bound. If you&#8217;re able to do that, you could sense for different metals, and different concentrations of those metals. There are a lot of big steps we want to accomplish, but I&#8217;m hopeful and excited.&#8221;\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/phys.org\/news\/2018-07-evolution-efflux-yield-important-insights.html\">Evolution of efflux pumps could yield important insights in fighting antibiotic resistance<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Kansas<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/www.ku.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/techx.b-cdn.net\/tmpl\/v2\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 &#8216;Deep fake&#8217; protein designed with artificial intelligence will target water pollutants (2022, October 21)<br \/>\n                                                 retrieved 21 October 2022<br \/>\n                                                 from https:\/\/techxplore.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-10-deep-fake-protein-artificial-intelligence.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/techxplore.com\/news\/2022-10-deep-fake-protein-artificial-intelligence.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;&#8216;Deep fake&#8217; protein designed with artificial intelligence will target water pollutants&#8221; A University of Kansas researcher will use machine learning to create \u201cdeep-fake\u201d membrane beta-barrel proteins \u2014 a class of naturally successful biosensors \u2014 designed to detect polluting metal ions in water. Credit: T. Chris Gamblin If you&#8217;ve ever used a text-based artificial-intelligence image generator&#8230;<\/p>\n","protected":false},"author":1,"featured_media":502535,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/deep-fake-protein-desi.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-502534","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/502534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=502534"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/502534\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/502535"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=502534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=502534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=502534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}