{"id":502798,"date":"2022-10-21T21:38:23","date_gmt":"2022-10-21T18:38:23","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/researchers-target-uncharacterized-protein-to-study-iron-rich-blood-molecule\/"},"modified":"2022-10-21T21:38:23","modified_gmt":"2022-10-21T18:38:23","slug":"researchers-target-uncharacterized-protein-to-study-iron-rich-blood-molecule","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/researchers-target-uncharacterized-protein-to-study-iron-rich-blood-molecule\/","title":{"rendered":"#Researchers target uncharacterized protein to study iron-rich blood molecule"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3a95a8ea196\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3a95a8ea196\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/researchers-target-uncharacterized-protein-to-study-iron-rich-blood-molecule\/#%E2%80%9CResearchers_target_uncharacterized_protein_to_study_iron-rich_blood_molecule%E2%80%9D\" >&#8220;Researchers target uncharacterized protein to study iron-rich blood molecule&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CResearchers_target_uncharacterized_protein_to_study_iron-rich_blood_molecule%E2%80%9D\"><\/span>&#8220;Researchers target uncharacterized protein to study iron-rich blood molecule&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/researchers-target-tan.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/researchers-target-tan.jpg\" data-sub-html=\"Amit Reddi, associate professor, School of Chemistry and Biochemistry. Credit: Georgia Tech\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/researchers-target-tan.jpg\" alt=\"Researchers target TANGO2 to study iron-rich blood molecule\" title=\"Amit Reddi, associate professor, School of Chemistry and Biochemistry. Credit: Georgia Tech\" width=\"500\" height=\"280\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Amit Reddi, associate professor, School of Chemistry and Biochemistry. Credit: Georgia Tech<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Heme, the iron-holding molecule that gives blood its red color, is essential for life. Yet, ironically, it can be quite toxic if not properly handled. In fact, numerous diseases\u2014from various cancers to cardiovascular diseases\u2014are associated with defects in heme homeostasis.\n                                                <\/p>\n<p>                                                                                The way heme is biosynthesized and degraded has been known for decades, but how it is mobilized from sites of synthesis and storage for use in cells has not been clear. Researchers at the Georgia Institute of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">Technology<\/a> have developed new tools and <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roaches to image, monitor, and probe heme in biological systems to study how organisms handle this essential but potentially cytotoxic metabolite. Their findings are published in the journal <i>Nature<\/i>.<\/p>\n<p>In a collaboration with Zhejiang University and the University of Maryland School of Medicine, the research team discovered a previously uncharacterized protein, HRG-9 (also called TANGO2), that helps to mobilize heme from sites of synthesis or storage for use in metabolism. The discovery of a new protein that ensures heme is made bio-available may serve as a new therapeutic target in many disease contexts\u2014either to limit heme, to starve cells of this essential nutrient, or to cause heme to over accumulate and render it toxic to cells.<\/p>\n<p>&#8220;Since mutations in the TANGO2 gene cause a hereditary disease characterized by developmental delays and defects in metabolism, our finding that TANGO2 plays a role in heme homeostasis suggests that the development of heme-centered therapies may treat such diseases,&#8221; said Amit Reddi, associate professor in the School of Chemistry at Georgia Tech and co-PI on the paper.<\/p>\n<p>The researchers hope that understanding the mechanisms of heme trafficking will provide clues about how such &#8216;essential toxins&#8217; are safely trafficked throughout the cell. It could also inspire therapeutic strategies to treat diseases associated with heme dysregulation, including anemias, porphyrias, and certain neurodegenerative and cardiovascular disorders\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/phys.org\/news\/2018-09-cells-sticky-toxic-absolutely-essential.html\">How cells handle a sticky, toxic, but absolutely essential molecule<\/a>\n                                                                                    <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Fengxiu Sun et al, HRG-9 homologues regulate haem trafficking from haem-enriched compartments, <i>Nature<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41586-022-05347-z\">DOI: 10.1038\/s41586-022-05347-z<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Georgia Institute of Technology<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.gatech.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Researchers target uncharacterized protein to study iron-rich blood molecule (2022, October 21)<br \/>\n                                                 retrieved 22 October 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-10-uncharacterized-protein-iron-rich-blood-molecule.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Credit: Georgia Tech Heme, the iron-holding molecule that gives blood its red color, is essential for life. Yet, ironically, it can be quite toxic if not properly handled. In fact, numerous diseases\u2014from various cancers to cardiovascular diseases\u2014are&#8230;<\/p>\n","protected":false},"author":1,"featured_media":502799,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/researchers-target-tan.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-502798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/502798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=502798"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/502798\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/502799"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=502798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=502798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=502798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}