{"id":509178,"date":"2022-11-12T01:29:19","date_gmt":"2022-11-11T22:29:19","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/capitalizing-on-cancer-immunotherapy-techniques-to-develop-a-potential-variant-proof-treatment-for-covid-19\/"},"modified":"2022-11-12T01:29:19","modified_gmt":"2022-11-11T22:29:19","slug":"capitalizing-on-cancer-immunotherapy-techniques-to-develop-a-potential-variant-proof-treatment-for-covid-19","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/capitalizing-on-cancer-immunotherapy-techniques-to-develop-a-potential-variant-proof-treatment-for-covid-19\/","title":{"rendered":"#Capitalizing on cancer immunotherapy techniques to develop a potential variant-proof treatment for COVID-19"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a37a5a88db2a\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a37a5a88db2a\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/capitalizing-on-cancer-immunotherapy-techniques-to-develop-a-potential-variant-proof-treatment-for-covid-19\/#%E2%80%9CCapitalizing_on_cancer_immunotherapy_techniques_to_develop_a_potential_variant-proof_treatment_for_COVID-19%E2%80%9D\" >&#8220;Capitalizing on cancer immunotherapy techniques to develop a potential variant-proof treatment for COVID-19&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CCapitalizing_on_cancer_immunotherapy_techniques_to_develop_a_potential_variant-proof_treatment_for_COVID-19%E2%80%9D\"><\/span>&#8220;Capitalizing on cancer immunotherapy techniques to develop a potential variant-proof treatment for COVID-19&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/capitalizing-on-cancer.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/capitalizing-on-cancer.jpg\" data-sub-html=\"Derya Unutmaz in his lab at The Jackson Laboratory. Credit: Tiffany L\u00e4ufer\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/capitalizing-on-cancer.jpg\" alt=\"Capitalizing on cancer immunotherapy techniques to develop a potential variant-proof treatment for COVID-19\" title=\"Derya Unutmaz in his lab at The Jackson Laboratory. Credit: Tiffany L\u00e4ufer\" width=\"800\" height=\"451\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Derya Unutmaz in his lab at The Jackson Laboratory. Credit: Tiffany L\u00e4ufer<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Millions have died due to COVID-19 infection, and millions more continue experiencing the chronic condition, Long COVID, which makes discovering practical, accessible, and powerful SARS-CoV-2 preventatives and COVID-19 treatments essential.\n                                                <\/p>\n<p>                                                                                At the nonprofit biomedical research institution, The Jackson Laboratory for Genomic Medicine, Derya Unutmaz, M.D., and his team have adapted what is typically a cancer therapeutic technique, CAR T cell therapy, for the purpose of eliminating SARS-CoV-2 virus. The study, published in <i>Clinical &amp; Translational Immunology<\/i>, demonstrates several immuno-based strategies to explore the treatment and prevention of COVID-19.<\/p>\n<p>The first immunotherapy method focuses on the spike protein present on SARS-CoV-2 and the receptor on the host cell, angiotensin-converting enzyme 2 (ACE2). The spike protein is the molecule on the surface of the virus that is responsible for infecting healthy host cells. The protein enters the cell via the ACE2 receptor, allowing the viral RNA to begin its takeover. In the Unutmaz study, T cells were engineered with anti-spike and anti-ACE2 CAR-T cells to target either the spike protein or the ACE2 receptor, with high specificity and efficiency across various infected cell types.<\/p>\n<p>The second immunotherapy method provides an antibody-based means for preventing COVID-19 infection. T cells were engineered with a bispecific antibody fused with ACE2 to activate the patient&#8217;s own T cells to destroy infected cells that present the SARS-CoV-2 Spike protein on their surface. Rather than having cells, modified outside of the body, kill the infected cells, ACE2-bispecific therapy activates the healthy T cells within the individual to target Spike+ cells post-infection.<\/p>\n<p>Unlike most present therapeutics, ACE2-bispecific modified cells take advantage of the ACE2 receptor to target the different presentations of the Spike protein across all SARS-CoV-2 variants, including Delta, Omicron and more. The ACE2-bispecific therapy can therefore provide more efficient elimination of variants with more powerful ACE2 binding. It can also act as a decoy to block viral entry into cells, offering a possible preventative strategy. <\/p>\n<p>Both the proposed COVID-19 CAR-T cell and ACE2-bispecific-based therapies offer promising potential strategies for future COVID-19 treatment and prevention.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Mikail Dogan et al, Targeting SARS\u2010CoV \u20102 infection through CAR\u2010T \u2010like bispecific T cell engagers incorporating ACE2, <i>Clinical &amp; Translational Immunology<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1002\/cti2.1421\">DOI: 10.1002\/cti2.1421<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Jackson Laboratory<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.jax.org\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Capitalizing on cancer immunotherapy techniques to develop a potential variant-proof treatment for COVID-19 (2022, November 11)<br \/>\n                                                 retrieved 12 November 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-11-capitalizing-cancer-immunotherapy-techniques-potential.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Tiffany L\u00e4ufer Millions have died due to COVID-19 infection, and millions more continue experiencing the chronic condition, Long COVID, which makes discovering practical, accessible, and powerful SARS-CoV-2 preventatives and COVID-19 treatments essential&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":509179,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/capitalizing-on-cancer.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-509178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/509178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=509178"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/509178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/509179"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=509178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=509178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=509178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}