{"id":513620,"date":"2022-11-21T23:00:05","date_gmt":"2022-11-21T20:00:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/intestinal-microorganisms-influence-white-blood-cell-levels-study-finds\/"},"modified":"2022-11-21T23:00:05","modified_gmt":"2022-11-21T20:00:05","slug":"intestinal-microorganisms-influence-white-blood-cell-levels-study-finds","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/intestinal-microorganisms-influence-white-blood-cell-levels-study-finds\/","title":{"rendered":"#Intestinal microorganisms influence white blood cell levels, study finds"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a37be9bd3070\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a37be9bd3070\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/intestinal-microorganisms-influence-white-blood-cell-levels-study-finds\/#%E2%80%9CIntestinal_microorganisms_influence_white_blood_cell_levels_study_finds%E2%80%9D\" >&#8220;Intestinal microorganisms influence white blood cell levels, study finds&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CIntestinal_microorganisms_influence_white_blood_cell_levels_study_finds%E2%80%9D\"><\/span>&#8220;Intestinal microorganisms influence white blood cell levels, study finds&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/intestinal-microorgani.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/intestinal-microorgani.jpg\" data-sub-html=\"Under normal conditions (steady state) neutrophils regulate the gut microbiota. When the number of neutrophils drops (neutropenia), the composition of the gut microbiota changes, stimulating T cells to produce IL-17A. IL-17-A in turn stimulates the production of neutrophils in the bone marrow (reactive granulopoiesis). Credit: Daigo Hashimoto\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/intestinal-microorgani.jpg\" alt=\"Intestinal microorganisms influence white blood cell levels in blood\" title=\"Under normal conditions (steady state) neutrophils regulate the gut microbiota. When the number of neutrophils drops (neutropenia), the composition of the gut microbiota changes, stimulating T cells to produce IL-17A. IL-17-A in turn stimulates the production of neutrophils in the bone marrow (reactive granulopoiesis). Credit: Daigo Hashimoto\" width=\"800\" height=\"440\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Under normal conditions (steady state) neutrophils regulate the gut microbiota. When the number of neutrophils drops (neutropenia), the composition of the gut microbiota changes, stimulating T cells to produce IL-17A. IL-17-A in turn stimulates the production of neutrophils in the bone marrow (reactive granulopoiesis). Credit: Daigo Hashimoto<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Intestinal bacteria composition is crucial to driving the recovery of neutrophil counts in the blood of mice following treatments such as stem cell transplants or chemotherapy.\n                                                <\/p>\n<p>                                                                                White blood cells, or granulocytes, are cells that are part of the innate immune system. The most common type of granulocyte is the neutrophil, a phagocyte that destroys microbes in the body. Low neutrophil counts in the blood is called neutropenia; this condition is commonly seen in cases of leukemia or following chemotherapy. It is known that neutropenia induces granulopoiesis, the process formation of granulocytes. However, the exact mechanisms by which neutropenia drives granulopoiesis are not fully understood.<\/p>\n<p>A team of researchers led by Associate Professor Daigo Hashimoto and Professor Takanori Teshima at Hokkaido University&#8217;s Faculty of Medicine have discovered that the gut microbiome plays a critical role in driving granulopoiesis in mice models. Their findings were published in the journal <i>Proceedings of the National Academy of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s<\/i>.<\/p>\n<p>The process of increasing granulopoiesis above a homeostatic level can be divided into emergency granulopoiesis, driven by the presence of bacteria, and reactive granulopoiesis, where granulopoiesis is increased in the absence of active microbial infections. It was known that reactive granulopoiesis occurs after neutropenia caused by hematopoietic stem cell transplantation (SCT) or cancer chemotherapy. The team wanted to understand the mechanisms by which neutropenia triggered reactive granulopoiesis in these two scenarios.<\/p>\n<p>The team induced prolonged neutropenia in mice models, and observed the levels of cytokines, cell signaling molecules, known to be associated with granulopoiesis. They found that two cytokines were significantly elevated: the granulocyte-colony stimulating factor (G-CSF) and interleukin 17A (IL-17A). They showed that IL-17A was critical for neutrophil recovery. They confirmed that T cells are the primary source of IL-17A.<\/p>\n<p>They were interested in examining if the gut microbiome influenced granulopoiesis, building on other research that suggested the gut microbiome and bone marrow hematopoiesis could affect each other. They found that the gut microbiome does upregulate reactive granulopoiesis via the IL-17A secreted by T cells, and also found that prolonged neutropenia alters the gut microbiome. They determined that it was this change in microbiome composition that enhanced reactive granulopoiesis.<\/p>\n<p>This study demonstrated that the changes in intestinal microbiome induced by neutropenia stimulates reactive granulopoiesis in the bone marrow via IL-17A secreted by T cells, promoting neutrophil recovery. Future work will focus on clinical trials to test if this crosstalk is found in humans; other avenues include the development of antibiotic formulations that leave granulopoiesis-supporting bacteria intact.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota, <i>Proceedings of the National Academy of Sciences<\/i> (2022). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1073\/pnas.2211230119\">DOI: 10.1073\/pnas.2211230119<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Hokkaido University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/www.global.hokudai.ac.jp\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Intestinal microorganisms influence white blood cell levels, study finds (2022, November 21)<br \/>\n                                                 retrieved 21 November 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-11-intestinal-microorganisms-white-blood-cell.html<\/p>\n<p>                                            This document is subject to copyright. 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When the number of neutrophils drops (neutropenia), the composition of the gut microbiota changes, stimulating T cells to produce IL-17A. IL-17-A in turn stimulates the production of neutrophils in the bone marrow (reactive granulopoiesis). Credit: Daigo&#8230;<\/p>\n","protected":false},"author":1,"featured_media":513621,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/intestinal-microorgani.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-513620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/513620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=513620"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/513620\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/513621"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=513620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=513620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=513620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}