{"id":515054,"date":"2022-11-24T04:00:01","date_gmt":"2022-11-24T01:00:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/scientists-reveal-first-close-up-look-at-bats-immune-response-to-live-infection\/"},"modified":"2022-11-24T04:00:01","modified_gmt":"2022-11-24T01:00:01","slug":"scientists-reveal-first-close-up-look-at-bats-immune-response-to-live-infection","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/scientists-reveal-first-close-up-look-at-bats-immune-response-to-live-infection\/","title":{"rendered":"#Scientists reveal first close-up look at bats&#8217; immune response to live infection"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a4ea232cc942\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a4ea232cc942\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/scientists-reveal-first-close-up-look-at-bats-immune-response-to-live-infection\/#%E2%80%9CScientists_reveal_first_close-up_look_at_bats_immune_response_to_live_infection%E2%80%9D\" >&#8220;Scientists reveal first close-up look at bats&#8217; immune response to live infection&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CScientists_reveal_first_close-up_look_at_bats_immune_response_to_live_infection%E2%80%9D\"><\/span>&#8220;Scientists reveal first close-up look at bats&#8217; immune response to live infection&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/scientists-reveal-firs.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/scientists-reveal-firs.jpg\" data-sub-html=\"Eonycteris spelaea as seen in a captive colony. Credit: Duke-NUS Medical School\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/scientists-reveal-firs.jpg\" alt=\"Scientists reveal first close-up look at bats\u2019 immune response to live infection\" title=\"Eonycteris spelaea as seen in a captive colony. Credit: Duke-NUS Medical School\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Eonycteris spelaea as seen in a captive colony. Credit: Duke-NUS Medical School<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>In a world first, scientists at Duke-NUS Medical School and colleagues in Singapore have sequenced the response to viral infection in colony-bred cave nectar bats (Eonycteris spelaea) at single-cell resolution. Published in the journal <i>Immunity<\/i>, the findings contribute to insights into bat immunity that could be harnessed to protect human health.\n                                                <\/p>\n<p>                                                                                Bats harbor many types of viruses. Even when they are infected with viruses deadly to humans, they show no notable signs or symptoms of disease. <\/p>\n<p>&#8220;It is our hope that by understanding how bats&#8217; immune responses protect them from infections, we may find clues that will help humans to better combat viral infections,&#8221; explained Dr. Akshamal Gamage, Research Fellow with Duke-NUS&#8217; Emerging Infectious Diseases (EID) Program and a co-first author of the study.<\/p>\n<p>&#8220;And knowing how to better fight viral infections can aid in the development of treatments that will help us to be more bat-like\u2014by falling sick less and aging better,&#8221; added Mr Wharton Chan, an MD-Ph.D. candidate at Duke-NUS who is also a co-first author of the study.<\/p>\n<p>In this study, the scientists investigated bat immune responses to Malacca virus, a double-stranded RNA virus that uses bats as its natural reservoir. This virus also causes mild respiratory disease in humans.<\/p>\n<p>The team used single-cell tran<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ome sequencing to study lung immune responses to infections at the cellular level, identifying the different types of immune cells in bats\u2014some of which are different from those in other mammals, including humans\u2014and uncovering what they do in response to such viral infections.<\/p>\n<p>They found that a type of white blood cell, called neutrophils, showed a very high expression of a gene called IDO1, which is known to play a role in <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>ting immune suppression in humans. The scientists believe that IDO1 expression in cave nectar bats could play an important role in limiting inflammation following infection.<\/p>\n<p>Dr. Feng Zhu, Research Fellow with the EID Program and a co-first author of the study, said, &#8220;We also found marked anti-viral gene signatures in white blood cells known as monocytes and alveolar macrophages, which\u2014in a sense\u2014consume viral particles and then teach T cells how to recognize the virus. This observation is interesting as it shows that bats clearly activate an immune response following infection despite showing few outward symptoms or pathology.&#8221;<\/p>\n<p>The team also identified an unusual diversity and abundance of T cells and natural killer cells\u2014named for their ability to kill tumor cells and cells infected with a virus\u2014in the cave nectar bat, which are broadly activated to respond to the infection.<\/p>\n<p>&#8220;This is the first study that details the bat immune response to in vivo infection at the single-cell transcriptome level,&#8221; said Professor Linfa Wang, senior author of the study from the EID Program. <\/p>\n<p>&#8220;We believe that our work serves as a key guide to inform further investigations into uncovering the remarkable biology of bats. Moving forward, besides studies into viral disease tolerance, we also hope to uncover clues to longevity from bats as long-lived mammals and also learn how these nectarivorous bats can live on the high sugar diet in nectar without getting diabetes.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Akshamal M. Gamage et al, Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea, <i>Immunity<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.immuni.2022.10.008\">DOI: 10.1016\/j.immuni.2022.10.008<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Duke-NUS Medical School<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/www.duke-nus.edu.sg\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Scientists reveal first close-up look at bats&#8217; immune response to live infection (2022, November 23)<br \/>\n                                                 retrieved 23 November 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-11-scientists-reveal-close-up-immune-response.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Duke-NUS Medical School In a world first, scientists at Duke-NUS Medical School and colleagues in Singapore have sequenced the response to viral infection in colony-bred cave nectar bats (Eonycteris spelaea) at single-cell resolution. Published&#8230;<\/p>\n","protected":false},"author":1,"featured_media":515055,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/scientists-reveal-firs.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-515054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/515054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=515054"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/515054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/515055"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=515054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=515054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=515054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}