{"id":526249,"date":"2022-12-13T18:35:04","date_gmt":"2022-12-13T15:35:04","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/researchers-identify-differences-in-spontaneous-brain-activity-in-people-with-down-syndrome\/"},"modified":"2022-12-13T18:35:04","modified_gmt":"2022-12-13T15:35:04","slug":"researchers-identify-differences-in-spontaneous-brain-activity-in-people-with-down-syndrome","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/researchers-identify-differences-in-spontaneous-brain-activity-in-people-with-down-syndrome\/","title":{"rendered":"#Researchers identify differences in spontaneous brain activity in people with Down syndrome"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3d538f4f237\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3d538f4f237\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/researchers-identify-differences-in-spontaneous-brain-activity-in-people-with-down-syndrome\/#%E2%80%9CResearchers_identify_differences_in_spontaneous_brain_activity_in_people_with_Down_syndrome%E2%80%9D\" >&#8220;Researchers identify differences in spontaneous brain activity in people with Down syndrome&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CResearchers_identify_differences_in_spontaneous_brain_activity_in_people_with_Down_syndrome%E2%80%9D\"><\/span>&#8220;Researchers identify differences in spontaneous brain activity in people with Down syndrome&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/researchers-identify-d-3.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/researchers-identify-d-3.jpg\" data-sub-html=\"fALFF analysis. Two-sample t test results are presented, corrected by a permutation test with TFCE, p\u2009&lt;\u20090.05. The area in blue represents a significantly decreased ALFF value in DS patients compared with controls; the area in yellow and red represents a significantly increased fALFF value in DS patients compared with controls. Credit: &lt;i&gt;Scientific Reports&lt;\/i&gt; (2022). DOI: 10.1038\/s41598-022-19627-1\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/researchers-identify-d-3.jpg\" alt=\"Researchers identify differences in spontaneous brain activity in people with Down syndrome\" title=\"fALFF analysis. Two-sample t test results are presented, corrected by a permutation test with TFCE, p\u2009 Scientific Reports  (2022). DOI: 10.1038\/s41598-022-19627-1\" width=\"800\" height=\"408\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                fALFF analysis. Two-sample t test results are presented, corrected by a permutation test with TFCE, p\u2009Scientific Reports (2022). DOI: 10.1038\/s41598-022-19627-1<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Researchers of the Faculty of Psychology, the Institute of Neuro<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>s (UBNeuro) and the Institute of Complex Systems (UBICS) of the University of Barcelona have identified, using functional magnetic resonance techniques, differences in the spontaneous activity of the brain in a resting state in people with Down syndrome (DS) compared to the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">general<\/a> population. Also, these variations could be related to cognitive skills.\n                                                <\/p>\n<p>                                                                                According to the authors, these results can help detect the anomalies of the cognitive functioning caused by this syndrome, and they point to this brain signal as a potential biomarker of neurodegeneration, &#8220;which is important given the difficulties to assess these people&#8217;s dementia.&#8221;<\/p>\n<p>The study, published in the journal <i>Scientific Reports<\/i>, includes the participation of the researchers Cristina Ca\u00f1ete (first author of the research), Maria Carb\u00f3 and Maribel Per\u00f3, led by Joan Gu\u00e0rdia, professor of Methodology of Behavioral Sciences at the Faculty of Psychology and current rector of the UB. The study also counted on the participation of the experts Shi-Xian Ciu and Chao-Gan Yan, from the Chinese Academy of Sciences in Beijing (China).<\/p>\n<p><b>Impact of Alzheimer&#8217;s disease on Down syndrome<\/b><\/p>\n<p>Down syndrome is the most frequent genetic cause of neurodevelopmental delay and it affects one out of every 700 births. These people&#8217;s life expectancy has dramatically increased over the last years, but with this increase, researchers have detected a growth of comorbidity due to illnesses such as Alzheimer&#8217;s disease. <\/p>\n<p>&#8220;Due to the high incidence of Alzheimer&#8217;s in Down syndrome, this population offers an extraordinary opportunity to understand the temporary progression of this dementia, the different sides that contribute to the age of the onset, and also to <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ly knowledge to the general population,&#8221; notes Joan Gu\u00e0rdia, professor at the Department of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">Social<\/a> Psychology and Quantitative Psychology of the UB.<\/p>\n<p>The research compared resting-state brain signals in 18 people with DS and in 18 people from a control group using functional magnetic resonance techniques, a type of study that allows the evaluation of the basal brain function and which is used to find differences between groups. <\/p>\n<p>Within this paradigm, they combined two analytical techniques based on diverse information. On the one hand, the fALFF, which measures the local spontaneous activity, and on the other, the ReHo analysis, which estimates the brain&#8217;s regional anomalies.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>&#8220;These tools are especially useful when we do not have studies nor hypotheses that can guide our research, like in this case, in which few studies have used these techniques focused on the whole brain,&#8221; notes Cristina Ca\u00f1ete.<\/p>\n<p>Moreover, this is the first study to apply this technique to a young adult sample\u2014average age of 28.7\u2014with DS. In this case, the age of the participants is very relevant, since it allows us to identify the brain activity before the first signs of dementia associated with this syndrome appear. <\/p>\n<p>&#8220;We have to consider that the neuropathology of Alzheimer&#8217;s is universal in all people with Down syndrome over 40 years old. This involves that in within a few years, major changes can occur in the brains of these people. Therefore, it is essential to focus the studies on young participants who have not yet developed the first signs of the pathology,&#8221; states the research group.<\/p>\n<p><b>A shocking connection to cognitive skills<\/b><\/p>\n<p>The results identified brain areas that show a different spontaneous activity between people with DS and the control groups, such as, for instance, in the frontal and temporal lobes. These two, relevant for executive and speech functions, and memory, have very altered functions in people with DS. The data were obtained using cognitive tests, including a verbal fluency test, on the participants. &#8220;The most shocking result was the strong link we found between the activation of the areas where we found differences and the cognitive tests,&#8221; notes the researcher.<\/p>\n<p>Given the results, one of the challenges for the research team was to see the reason these variations take place, and in what way they affect the neuropathological features of this syndrome. &#8220;These areas seem essential in the syndrome and could be related to brain structural differences, to the functions of these areas, which are affected in the population with Down syndrome, or which could even be related to the early accumulation of \u03b2-amyloid plaques, typical in Alzheimer&#8217;s disease, in this population,&#8221; notes Cristina Ca\u00f1ete.<\/p>\n<p>Moreover, the study opens the door to using the brain signal to assess the neurodegeneration of people with Down syndrome. &#8220;The difficulties in the cognitive evaluation of this population are huge and we need new methods which are more reliable and valid. Therefore, a new research line we have to study is the use of the brain signal as a biomarker of cognitive skills or to detect dementia early,&#8221; concludes the researcher.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Cristina Ca\u00f1ete-Mass\u00e9 et al, Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome, <i>Scientific Reports<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41598-022-19627-1\">DOI: 10.1038\/s41598-022-19627-1<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Barcelona<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.ub.edu\/homeub\/en\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Researchers identify differences in spontaneous brain activity in people with Down syndrome (2022, December 13)<br \/>\n                                                 retrieved 13 December 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-12-differences-spontaneous-brain-people-syndrome.html<\/p>\n<p>                                            This document is subject to copyright. 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Two-sample t test results are presented, corrected by a permutation test with TFCE, p\u2009Scientific Reports (2022). DOI: 10.1038\/s41598-022-19627-1 Researchers of the Faculty of Psychology, the Institute of Neurosciences (UBNeuro) and the Institute of Complex Systems (UBICS) of the University of Barcelona&#8230;<\/p>\n","protected":false},"author":1,"featured_media":526250,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/researchers-identify-d-3.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-526249","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/526249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=526249"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/526249\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/526250"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=526249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=526249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=526249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}