{"id":532041,"date":"2022-12-28T17:00:03","date_gmt":"2022-12-28T14:00:03","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-technique-improves-high-intensity-focused-ultrasound-treatment-for-brain-disorders\/"},"modified":"2022-12-28T17:00:03","modified_gmt":"2022-12-28T14:00:03","slug":"new-technique-improves-high-intensity-focused-ultrasound-treatment-for-brain-disorders","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-technique-improves-high-intensity-focused-ultrasound-treatment-for-brain-disorders\/","title":{"rendered":"#New technique improves high-intensity focused ultrasound treatment for brain disorders"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3f0ebcb3dbb\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3f0ebcb3dbb\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-technique-improves-high-intensity-focused-ultrasound-treatment-for-brain-disorders\/#%E2%80%9CNew_technique_improves_high-intensity_focused_ultrasound_treatment_for_brain_disorders%E2%80%9D\" >&#8220;New technique improves high-intensity focused ultrasound treatment for brain disorders&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CNew_technique_improves_high-intensity_focused_ultrasound_treatment_for_brain_disorders%E2%80%9D\"><\/span>&#8220;New technique improves high-intensity focused ultrasound treatment for brain disorders&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/new-technique-improves-4.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/new-technique-improves-4.jpg\" data-sub-html=\"Graphical abstract. Credit: &lt;i&gt;Brain Communications&lt;\/i&gt; (2022). DOI: 10.1093\/braincomms\/fcac273\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/new-technique-improves-4.jpg\" alt=\"New technique improves high-intensity focused ultrasound treatment for brain disorders\" title=\"Graphical abstract. Credit:  Brain Communications  (2022). DOI: 10.1093\/braincomms\/fcac273\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Graphical abstract. Credit: <i>Brain Communications<\/i> (2022). DOI: 10.1093\/braincomms\/fcac273<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>UT Southwestern physicians have developed an improved targeting method, four-tract tractography, to personalize MRI-guided, high-intensity focused ultrasound (HIFU) used at UTSW to treat medication refractory tremor in essential tremor and tremor-dominant Parkinson&#8217;s disease. Results of the clinical cases utilizing this <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach, published in <i>Brain Communications<\/i>, suggest that it enables more precise targeting of the brain, decreases treatment times, reduces side effects and improves treatment response.\n                                                <\/p>\n<p>                                                                                &#8220;Historically, the target for tremor could not be seen on standard high-resolution magnetic resonance images, so landmark-based methods have been used,&#8221; said Bhavya R. Shah, M.D., assistant professor of radiology and neurological surgery, investigator in the Peter O&#8217;Donnell Jr. Brain Institute, and corresponding author. &#8220;By using tractography and other advanced magnetic resonance methods, we are working to identify the precise location of the target in individual patients and improve patient outcomes.&#8221;<\/p>\n<p>MRI-guided HIFU ablation of the ventral inter<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>te nucleus of the thalamus has been approved by the Food and Drug Administration for treatment of essential tremor and tremor-dominant Parkinson&#8217;s. The efficacy and safety of the procedure are dependent on precise targeting; however, MRI cannot directly delineate the target. Thus, indirect methods using landmarks are utilized to identify the correct region.<\/p>\n<p>Use of indirect targeting for HIFU ablation can result in significant adverse side effects, including weakness, numbness, and paresthesia in nearly a third of patients one month post-treatment, that might be mitigated by using techniques to more directly target the region of the brain and identify regions to avoid.<\/p>\n<p>To this end, the UT Southwestern physicians developed an improved, standardized four-tract tractography for HIFU using an FDA-approved surgical planning software that will allow for easy implementation into clinics.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/new-technique-improves-5.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/new-technique-improves-5.jpg\" data-sub-html=\"Four-tract tractography identifies white-matter tracts in the brain, shown in 3D renderings, for treatment with MRI-guided, high-intensity focused ultrasound (HIFU). Credit: UT Southwestern Medical Center\">\n<figure class=\"article-img text-center\"><img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/new-technique-improves-5.jpg\" alt=\"New technique improves high-intensity focused ultrasound treatment for brain disorders\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Four-tract tractography identifies white-matter tracts in the brain, shown in 3D renderings, for treatment with MRI-guided, high-intensity focused ultrasound (HIFU). Credit: UT Southwestern Medical Center<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>The four-tract tractography method builds off previous work by Dr. Shah, published in <i><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/academic.oup.com\/brain\/article\/143\/9\/2664\/5856628\">Brain<\/a><\/i> in 2020, in which the researchers demonstrated the feasibility of advanced MRI techniques to identify tremor-associated white-matter tracts.<\/p>\n<p>In the latest study, data were analyzed from 18 patients who underwent MRI-guided HIFU and had at least three months of follow-up post-treatment.<\/p>\n<p>Use of the four-tract tractography for ablation suggests that this method yields decreased adverse effects. None of the patients experienced weakness, numbness, or paresthesia post-treatment; three patients experienced transient (three weeks) imbalance, common after magnetic resonance-guided HIFU.<\/p>\n<p>Though this retrospective review was limited by a small sample size of patients treated in one center with a short follow-up, the results suggest promise for four-tract tractography to produce better outcomes for patients who need this procedure. A multicenter trial is planned with other U.S. sites, including the University of California San Francisco, the Mayo Clinic in Rochester, Minnesota, the University of Colorado, and an international site in Spain.<\/p>\n<p>Several other sites have arranged to come to UTSW to work with Dr. Shah to learn his approach. This work represents a step forward in using advanced imaging to create personalized solutions for these patients, said Dr. Shah.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Fabricio S Feltrin et al, Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance\u2013guided high-intensity focused ultrasound targeting, <i>Brain Communications<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1093\/braincomms\/fcac273\">DOI: 10.1093\/braincomms\/fcac273<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    UT Southwestern Medical Center<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www8.utsouthwestern.edu\/index.html\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New technique improves high-intensity focused ultrasound treatment for brain disorders (2022, December 28)<br \/>\n                                                 retrieved 28 December 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-12-technique-high-intensity-focused-ultrasound-treatment.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Brain Communications (2022). DOI: 10.1093\/braincomms\/fcac273 UT Southwestern physicians have developed an improved targeting method, four-tract tractography, to personalize MRI-guided, high-intensity focused ultrasound (HIFU) used at UTSW to treat medication refractory tremor in essential tremor and tremor-dominant Parkinson&#8217;s disease. Results of the clinical&#8230;<\/p>\n","protected":false},"author":1,"featured_media":532042,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/new-technique-improves-4.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-532041","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/532041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=532041"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/532041\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/532042"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=532041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=532041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=532041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}