{"id":541649,"date":"2023-01-20T23:05:32","date_gmt":"2023-01-20T20:05:32","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/"},"modified":"2023-01-20T23:05:32","modified_gmt":"2023-01-20T20:05:32","slug":"female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/","title":{"rendered":"#Female and male hearts respond differently to stress hormone in mouse study"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a414fbd5d428\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a414fbd5d428\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/#%E2%80%9CFemale_and_male_hearts_respond_differently_to_stress_hormone_in_mouse_study%E2%80%9D\" >&#8220;Female and male hearts respond differently to stress hormone in mouse study&#8221;<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/#Heart_disease_is_the_leading_cause_of_death_in_the_US\" >Heart disease is the leading cause of death in the US<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/#Methods\" >Methods<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/buradabiliyorum.com\/en\/female-and-male-hearts-respond-differently-to-stress-hormone-in-mouse-study\/#Including_female_mice_leads_to_discoveries\" >Including female mice leads to discoveries<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CFemale_and_male_hearts_respond_differently_to_stress_hormone_in_mouse_study%E2%80%9D\"><\/span>&#8220;Female and male hearts respond differently to stress hormone in mouse study&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/female-and-male-hearts.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/female-and-male-hearts.jpg\" data-sub-html=\"Professor Crystal M. Ripplinger (left) and Post-Doctoral Scholar Jessica L. Caldwell (right), UC Davis School of Medicine Department of Pharmacology. Credit: UC Davis\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/female-and-male-hearts.jpg\" alt=\"Female and male hearts respond differently to stress hormone in mouse study\" title=\"Professor Crystal M. Ripplinger (left) and Post-Doctoral Scholar Jessica L. Caldwell (right), UC Davis School of Medicine Department of Pharmacology. Credit: UC Davis\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Professor Crystal M. Ripplinger (left) and Post-Doctoral Scholar Jessica L. Caldwell (right), UC Davis School of Medicine Department of Pharmacology. Credit: UC Davis<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.add5799\">new study<\/a> published in <i><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a> Advances<\/i> shows female and male hearts respond differently to the stress hormone noradrenaline. The study in mice may have implications for human heart disorders like arrhythmias and heart failure and how different sexes respond to medications.\n                                                <\/p>\n<p>The team built a new type of <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4198327\/\">fluorescence imaging<\/a> system that allows them to use light to see how a mouse heart responds to hormones and neurotransmitters in real time. The mice were exposed to noradrenaline, also known as norepinephrine. Noradrenaline is both a neurotransmitter and hormone associated with the body&#8217;s &#8220;fight or flight&#8221; response.<\/p>\n<p>The results reveal that male and female mouse hearts respond uniformly at first after exposure to noradrenaline. However, some areas of the female heart return to normal more quickly than the male heart, which produces differences in the heart&#8217;s electrical activity.<\/p>\n<p>&#8220;The differences in electrical activity that we observed are called repolarization in the female hearts. Repolarization refers to how the heart resets between each heartbeat and is closely linked to some types of arrhythmias,&#8221; said Jessica L. Caldwell, first author of the study. Caldwell is a postdoctoral scholar in the UC Davis School of Medicine Department of Pharmacology.<\/p>\n<p>&#8220;We know that there are sex differences in the risk for certain types of arrhythmias. The study reveals a new factor that may contribute to different arrhythmia susceptibility between men and women,&#8221; Caldwell said.\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Heart_disease_is_the_leading_cause_of_death_in_the_US\"><\/span>Heart disease is the leading cause of death in the US<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Heart disease is the leading cause of death for both <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cdc.gov\/heartdisease\/men.htm\">men<\/a> and <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cdc.gov\/heartdisease\/men.htm\">women<\/a> in the United States. It accounted for about 1 in every 4 male deaths and <b>1 <\/b>in every 5 female deaths in 2020. Despite the impact on both sexes, cardiology research has largely been <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(19)30510-0\/fulltext\">performed on male subjects<\/a>.<\/p>\n<p>In this study, the researchers were interested in looking at factors that may contribute to arrhythmias. Arrhythmias are a type of heart disorder where the electrical impulses that control heartbeats don&#8217;t function properly. They affect somewhere between <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK558923\/\">1.5% to 5%<\/a> of the population.\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Methods\"><\/span>Methods<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The novel imaging system uses a mouse, called the CAMPER mouse, that has been genetically modified to emit light during a very specific chemical reaction in the heart\u2014cAMP binding.<\/p>\n<p>The cAMP molecule (an abbreviation of cyclic adenosine 3&#8242;,5;-monophosphate) is an inter<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>te messenger that turns signals from hormones and neurotransmitters, including noradrenaline, into action from heart cells.<\/p>\n<p>The light signals from the CAMPER mouse are transmitted by a biosensor that uses fluorescence resonance energy transfer (<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2173363\/\">FRET<\/a>). This FRET signal can be picked up at high speed and high resolution by a new imaging system specially designed for hearts. This allows the researchers to record the heart&#8217;s reaction to noradrenaline in real time, along with changes in electrical activity.<\/p>\n<p>This new imaging <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach revealed the differences in the breakdown of cAMP in female and male mice and the associated differences in electrical activity.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\"><meta itemprop=\"name\" content=\"Female and male hearts respond differently to stress hormone in mouse study\"\/><meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=G15xSzAIWoc\"\/><meta itemprop=\"description\" content=\"After being exposed to noradrenaline, cAMP (cyclic adenosine 3',5;-monophosphate) in the heart increases. However, the bottom of the heart\u2014the apex\u2014returns to normal more quickly in females than males. The findings may have implications for heart disorders like arrhythmias. Credit: UC Davis\"\/><meta itemprop=\"uploadDate\" content=\"2023-01-20T15:03:23-05:00\"\/><meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/G15xSzAIWoc\"\/><meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/G15xSzAIWoc\/maxresdefault.jpg\"\/><\/p>\n<p>\n             <iframe loading=\"lazy\" title=\"Female and male hearts respond differently to stress hormone in mouse study\" width=\"640\" height=\"480\" src=\"https:\/\/www.youtube.com\/embed\/G15xSzAIWoc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">After being exposed to noradrenaline, cAMP (cyclic adenosine 3&#8242;,5;-monophosphate) in the heart increases. However, the bottom of the heart\u2014the apex\u2014returns to normal more quickly in females than males. The findings may have implications for heart disorders like arrhythmias. Credit: UC Davis<\/figcaption><\/figure>\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Including_female_mice_leads_to_discoveries\"><\/span>Including female mice leads to discoveries<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The researchers had not planned to study sex-based responses, according to Crystal M. Ripplinger, senior author of the study. But the researchers started seeing a pattern of different reactions, which led them to realize the differences were sex-based.<\/p>\n<p>Ripplinger, an electrical and biomedical engineer, is a professor in the Department of Pharmacology.<\/p>\n<p>When she started her lab at the UC Davis School of Medicine over a decade ago, she exclusively used male animals. That was the norm for most research at the time. But several years ago, she began including male and female animals in her studies.<\/p>\n<p>&#8220;Sometimes the data between the two sexes is the same. But if the data start to show variation, the first thing we do is look at sex differences. Using both male and female mice has revealed clues into differences we would never have suspected. Researchers are realizing you can&#8217;t extrapolate to both sexes from only studying one,&#8221; Ripplinger said.<\/p>\n<p>She notes that with the current study, it&#8217;s not clear what the differences in cAMP and electrical activity may mean.<\/p>\n<p>&#8220;The response in the female mice may be protective\u2014or it may not. But simply documenting that there is a measurable difference in the response to a stress hormone is significant. We are hoping to learn more in future studies,&#8221; Ripplinger said.<\/p>\n<p>Additional authors on the study include I-Ju (Eric) Lee, Lena Ngo, Lianguo Wang, Donald M. Bers, Manuel F. Navedo and Julie Bossuyt from UC Davis; Sherif Bahriz from UC Davis and Mansoura University; Bing (Rita) Xu and Yang K. Xiang from UC Davis and VA Northern California.<\/p>\n<div class=\"article-main__more p-4\">\n<p>\n                                                        <strong>More information:<\/strong><br \/>\n                                                        Jessica L. Caldwell et al, Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics, <i>Science Advances<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/sciadv.add5799\">DOI: 10.1126\/sciadv.add5799<\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Female and male hearts respond differently to stress hormone in mouse study (2023, January 20)<br \/>\n                                                 retrieved 20 January 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-01-female-male-hearts-differently-stress.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Ripplinger (left) and Post-Doctoral Scholar Jessica L. Caldwell (right), UC Davis School of Medicine Department of Pharmacology. Credit: UC Davis A new study published in Science Advances shows female and male hearts respond differently to the stress hormone noradrenaline. The&#8230;<\/p>\n","protected":false},"author":1,"featured_media":541650,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/female-and-male-hearts.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-541649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/541649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=541649"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/541649\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/541650"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=541649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=541649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=541649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}