{"id":543022,"date":"2023-01-24T19:39:03","date_gmt":"2023-01-24T16:39:03","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/propionic-acid-protects-nerve-cells-and-helps-them-regenerate-shows-study\/"},"modified":"2023-01-24T19:39:03","modified_gmt":"2023-01-24T16:39:03","slug":"propionic-acid-protects-nerve-cells-and-helps-them-regenerate-shows-study","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/propionic-acid-protects-nerve-cells-and-helps-them-regenerate-shows-study\/","title":{"rendered":"#Propionic acid protects nerve cells and helps them regenerate, shows study"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2c3f221dbe4\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2c3f221dbe4\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/propionic-acid-protects-nerve-cells-and-helps-them-regenerate-shows-study\/#%E2%80%9CPropionic_acid_protects_nerve_cells_and_helps_them_regenerate_shows_study%E2%80%9D\" >&#8220;Propionic acid protects nerve cells and helps them regenerate, shows study&#8221;<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/propionic-acid-protects-nerve-cells-and-helps-them-regenerate-shows-study\/#Propionate_reduces_cell_death_in_cell_culture_experiments\" >Propionate reduces cell death in cell culture experiments<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CPropionic_acid_protects_nerve_cells_and_helps_them_regenerate_shows_study%E2%80%9D\"><\/span>&#8220;Propionic acid protects nerve cells and helps them regenerate, shows study&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/propionic-acid-protect.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/propionic-acid-protect.jpg\" data-sub-html=\"Nerve cell growth with (left) and without the administration of propionate (right). Credit: Dr. Thomas Gr\u00fcter und Niklas Rilke\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/propionic-acid-protect.jpg\" alt=\"Propionic acid protects nerve cells and helps them regenerate\" title=\"Nerve cell growth with (left) and without the administration of propionate (right). Credit: Dr. Thomas Gr\u00fcter und Niklas Rilke\" width=\"800\" height=\"423\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Nerve cell growth with (left) and without the administration of propionate (right). Credit: Dr. Thomas Gr\u00fcter und Niklas Rilke<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Some autoimmune diseases attack the nerves in the arms and legs. Bochum-based researchers are pursuing a new <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach to counteracting this damage.\n                                                <\/p>\n<p>Researchers at St. Josef Hospital Bochum have shown in lab experiments that propionate, i.e. the salt of a short-chain fatty acid, can protect nerves and help them regenerate. The findings could be useful for treating autoimmune diseases that cause damage to nerve cells, such as chronic inflammatory demyelinating polyneuropathy (CIDP). Propionate is naturally produced in the intestine when dietary fiber is broken down.<\/p>\n<p>In previous studies, a team from the same department at St. Josef Hospital Bochum, clinic of Ruhr University Bochum, Germany, had already demonstrated that people with multiple sclerosis (MS) are deficient in propionate and can benefit from taking additional propionate.<\/p>\n<p>Accordingly, the substance could also be useful for patients with CIDP.<\/p>\n<p>The group headed by Dr. Thomas Gr\u00fcter and Dr. Kalliopi Pitarokoili from the neurological clinic at St. Josef Hospital published their results in the journal <i>Proceedings of the National Academy of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s of the United States of America<\/i>.\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Propionate_reduces_cell_death_in_cell_culture_experiments\"><\/span>Propionate reduces cell death in cell culture experiments<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>CIDP patients suffer from sensory disturbances, muscle weakness and pain. The cause of the disorder is not fully understood. The immune system attacks the nerves in the arms and legs. The nerve sheath, an insulating coating around the nerve cells, is broken down and eventually the cells die. &#8220;The drugs that are currently available in the market are very expensive and primarily act on the immune system,&#8221; says Thomas Gr\u00fcter. &#8220;A therapy that protects the nerves and aids regeneration is not yet available.&#8221;<\/p>\n<p>In the current study, Thomas Gr\u00fcter&#8217;s team has now explored the protective effect of propionate in cell culture and in animal experiments. The group isolated the two most important cell types in the peripheral nervous system from rats: nerve cells and Schwann cells; the latter form the sheath of the nerve cells.<\/p>\n<p>The researchers cultivated the two cell types separately and exposed them to oxidative stress, which usually causes damage to the cells. The team treated some cell cultures with propionate and compared the effects with untreated cultures. Significantly fewer cells died in the treated cultures. In addition, the cells grew back more readily after treatment than when no propionate had been administered. Animal experiments confirmed these results: after administering propionate, the nerve cells had better protection against oxidative damage.<\/p>\n<p>The researchers also gained new insights into the mechanism of propionate action. They showed that the substance targets the receptor FFAR3 on the surface of nerve cells and Schwann cells and also affects the reading of DNA via histone molecules. This produces new enzymes and proteins that protect against harmful influences and help repair damage.<\/p>\n<p>The findings from previous studies with MS patients suggested to the Bochum researchers that propionate could have a beneficial effect on CIDP patients. The research group headed by Professor Aiden Haghikia had shown that taking propionate has an anti-inflammatory effect in people with multiple sclerosis and reduces the relapse rate.<\/p>\n<div class=\"article-main__more p-4\">\n<p>\n                                                        <strong>More information:<\/strong><br \/>\n                                                        Thomas Gr\u00fcter et al, Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system, <i>Proceedings of the National Academy of Sciences<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1073\/pnas.2216941120\">DOI: 10.1073\/pnas.2216941120<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Ruhr-Universitaet-Bochum<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.ruhr-uni-bochum.de\/index_en.htm\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Propionic acid protects nerve cells and helps them regenerate, shows study (2023, January 24)<br \/>\n                                                 retrieved 24 January 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-01-propionic-acid-nerve-cells-regenerate.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Credit: Dr. Thomas Gr\u00fcter und Niklas Rilke Some autoimmune diseases attack the nerves in the arms and legs. Bochum-based researchers are pursuing a new approach to counteracting this damage. Researchers at St&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":543023,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/propionic-acid-protect.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-543022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/543022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=543022"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/543022\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/543023"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=543022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=543022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=543022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}