{"id":547244,"date":"2023-02-03T01:01:37","date_gmt":"2023-02-02T22:01:37","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/statistics-framework-to-remove-bias-from-debate-about-how-well-mouse-models-mimic-human-disease\/"},"modified":"2023-02-03T01:01:37","modified_gmt":"2023-02-02T22:01:37","slug":"statistics-framework-to-remove-bias-from-debate-about-how-well-mouse-models-mimic-human-disease","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/statistics-framework-to-remove-bias-from-debate-about-how-well-mouse-models-mimic-human-disease\/","title":{"rendered":"#Statistics framework to remove bias from debate about how well mouse models mimic human disease"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a41fccfae418\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a41fccfae418\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/statistics-framework-to-remove-bias-from-debate-about-how-well-mouse-models-mimic-human-disease\/#%E2%80%9CStatistics_framework_to_remove_bias_from_debate_about_how_well_mouse_models_mimic_human_disease%E2%80%9D\" >&#8220;Statistics framework to remove bias from debate about how well mouse models mimic human disease&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CStatistics_framework_to_remove_bias_from_debate_about_how_well_mouse_models_mimic_human_disease%E2%80%9D\"><\/span>&#8220;Statistics framework to remove bias from debate about how well mouse models mimic human disease&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/lab-mouse-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/lab-mouse-2.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/lab-mouse-2.jpg\" alt=\"lab mouse\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"521\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Mice and other animals have been key to some of the biggest medical breakthroughs in human history. But animals aren&#8217;t always good models of human disease, leading to failed experiments and controversy over their usefulness.\n                                                <\/p>\n<p>A team of biostatisticians led by University of Pittsburgh School of Public Health scientists announced today in <i>PNAS<\/i> that they&#8217;ve developed a framework to determine how much congruence and discordance laboratory animals have with specific human diseases. The tool removes potential bias from scientific interpretation of how translational animal data is for human conditions.<\/p>\n<p>&#8220;There have been decades of debate about whether animal models mimic humans well and whether they are useful for translational or clinical research,&#8221; said senior author George Tseng, Sc.D., professor and vice chair for research in Pitt Public Health&#8217;s Department of Biostatistics. &#8220;Our framework is the first to provide quantitative methods and bioinformatic workflow to properly address that debate.&#8221;<\/p>\n<p>Tseng and his team tackled the topic after two papers published in <i>PNAS<\/i>\u2014one in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23401516\/\">2013<\/a> and one in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25092317\/\">2014<\/a>\u2014that used the same datasets presented contradictory conclusions on the usefulness of mice as models of human diseases that involve inflammation, such as sepsis and burns.<\/p>\n<p>The team reanalyzed the datasets in the contradictory <i>PNAS<\/i> papers with their Congruence Analysis for Model Organisms (CAMO) framework. It found that for the six human inflammatory disorders studied, two were well mimicked by mice; two were not, and two did not have enough data to draw conclusions. Tseng&#8217;s team determined that the previous studies reached different endpoints because the scientific teams\u2014one mostly composed of laboratory-based scientists and the other primarily of clinicians\u2014had used different thresholds, or cut-off points, for their analyses.<\/p>\n<p>&#8220;The conclusion drawn by our unbiased, threshold-free framework is much more realistic,&#8221; Tseng said. &#8220;In the end, you cannot say that the mouse model is totally useless or totally perfect. A mouse model can mimic some biological mechanisms well but others poorly. The issue is whether it mimics the mechanism of interest, such as the drug target. And it even revealed that the data aren&#8217;t perfect in some situations\u2014if you have limited information, you can&#8217;t draw a conclusion.&#8221;<\/p>\n<p>The team is extending their research into cancer to examine which cell-cultured models are good mimics for tumors and psychiatric disorders to learn, for example, whether mice mimic the human circadian rhythm.<\/p>\n<p>&#8220;We anticipate CAMO becoming an essential part of preclinical studies to solve all manner of human diseases,&#8221; Tseng said.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Wei Zong et al, Tran<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>omic congruence analysis for evaluating model organisms, <i>Proceedings of the National Academy of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1073\/pnas.2202584120\">DOI: 10.1073\/pnas.2202584120<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Pittsburgh<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.pitt.edu\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Statistics framework to remove bias from debate about how well mouse models mimic human disease (2023, February 2)<br \/>\n                                                 retrieved 3 February 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-02-statistics-framework-bias-debate-mouse.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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But animals aren&#8217;t always good models of human disease, leading to failed experiments and controversy over their usefulness. A&#8230;<\/p>\n","protected":false},"author":1,"featured_media":547245,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/lab-mouse-2.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-547244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/547244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=547244"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/547244\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/547245"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=547244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=547244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=547244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}