{"id":547705,"date":"2023-02-04T01:34:47","date_gmt":"2023-02-03T22:34:47","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-treatment-approach-for-prostate-cancer-could-stop-resistance-in-its-tracks\/"},"modified":"2023-02-04T01:34:47","modified_gmt":"2023-02-03T22:34:47","slug":"new-treatment-approach-for-prostate-cancer-could-stop-resistance-in-its-tracks","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-treatment-approach-for-prostate-cancer-could-stop-resistance-in-its-tracks\/","title":{"rendered":"#New treatment approach for prostate cancer could stop resistance in its tracks"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3fa8f606ec3\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3fa8f606ec3\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-treatment-approach-for-prostate-cancer-could-stop-resistance-in-its-tracks\/#%E2%80%9CNew_treatment_approach_for_prostate_cancer_could_stop_resistance_in_its_tracks%E2%80%9D\" >&#8220;New treatment approach for prostate cancer could stop resistance in its tracks&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CNew_treatment_approach_for_prostate_cancer_could_stop_resistance_in_its_tracks%E2%80%9D\"><\/span>&#8220;New treatment approach for prostate cancer could stop resistance in its tracks&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/prostate-cancer-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/prostate-cancer-2.jpg\" data-sub-html=\"Prostate cancer cells. Credit: NIH Image Gallery\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/prostate-cancer-2.jpg\" alt=\"prostate cancer\" title=\"Prostate cancer cells. Credit: NIH Image Gallery\" width=\"740\" height=\"444\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Prostate cancer cells. Credit: NIH Image Gallery<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>For the first time, researchers have discovered that prostate cancer can be killed by targeting a single enzyme, called PI5P4K\u03b1. The findings, published recently in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ade8641\"><i>Science Advances<\/i><\/a>, could help address the growing threat of treatment resistance in prostate cancer and could also lead to improved treatments for other cancers, such as those affecting the breast, skin, and pancreas.\n                                                <\/p>\n<p>&#8220;This is the first time this enzyme has been implicated in prostate cancer, and we expect that it will prove relevant to other cancers as well,&#8221; says co-senior author Brooke Emerling, Ph.D., an associate professor at Sanford Burnham Prebys. &#8220;An important element of improving precision medicine is using as many tools as possible to treat cancer while mitigating the risk of resistance.&#8221;<\/p>\n<p>Many cases of prostate cancer can be treated through treatments that lower testosterone and other male sex hormones, but about 10\u201320% of prostate cancer cases resist treatment within five years. This treatment-resistant prostate cancer can then spread to the rest of the body, where it becomes deadly.<\/p>\n<p>&#8220;Understanding how prostate cancer develops resistance is critical for discovering new therapeutic strategies to delay or reverse the progression of prostate cancer,&#8221; says Emerling.<\/p>\n<p>The prostate gland requires male sex hormones, known as androgens, to grow. Prostate cancer hijacks the androgen signaling machinery of the prostate in order to grow rapidly, which is why treatments that disrupt these pathways are effective.<\/p>\n<p>&#8220;What&#8217;s remarkable is that we&#8217;ve found an enzyme that can be targeted against prostate cancer even in cases where treatments that lower hormones are ineffective or where resistance has developed,&#8221; says Emerling. &#8220;This could give us a whole new weapon against prostate cancer and other cancers that rely on this enzyme.&#8221;<\/p>\n<p>The study was prompted by an observation made by Emerling&#8217;s colleagues at the University of Bern, led by co-senior author Mark A. Rubin. They noticed that patients with treatment-resistant prostate cancer had high levels of PI5P4K\u03b1, suggesting that this protein played a role in the cancer&#8217;s ability to resist treatment and grow. Emerling&#8217;s team was then able to show\u2014using multiple prostate cancer model systems\u2014that inhibiting this enzyme could kill treatment-resistant prostate cancer.<\/p>\n<p>&#8220;It was that initial observation from the patient data that really got us excited,&#8221; adds Emerling.<\/p>\n<p>PI5P4K\u03b1 is part of a group of enzymes called PI5P4Ks that are involved in the metabolism of lipids, a type of molecule that includes fats, hormones, and many vitamins. While other areas of cancer metabolism have been extensively researched for decades, lipid metabolism has only recently emerged as a promising therapeutic avenue for cancer.<\/p>\n<p>&#8220;Treatments that target lipid metabolism could be an unexplored treasure trove, and it&#8217;s something researchers are very interested in right now,&#8221; says Emerling. &#8220;We&#8217;re working to develop drugs to target this enzyme, and there are several companies out there developing their own drugs as well.&#8221;<\/p>\n<p>Because of this interest, Emerling and her colleagues are optimistic about the future of this treatment <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach.<\/p>\n<p>She says, &#8220;There&#8217;s no drug yet, but I have high hopes that in the near future, we&#8217;ll have something in clinical trials. That would be amazing.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Joanna Triscott et al, PI5P4K\u03b1 supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition, <i><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a> Advances<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/sciadv.ade8641\">DOI: 10.1126\/sciadv.ade8641<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Sanford Burnham Prebys Medical Discovery Institute<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.sbpdiscovery.org\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New treatment approach for prostate cancer could stop resistance in its tracks (2023, February 3)<br \/>\n                                                 retrieved 4 February 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-02-treatment-approach-prostate-cancer-resistance.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: NIH Image Gallery For the first time, researchers have discovered that prostate cancer can be killed by targeting a single enzyme, called PI5P4K\u03b1. The findings, published recently in Science Advances, could help address the growing threat of treatment resistance&#8230;<\/p>\n","protected":false},"author":1,"featured_media":547706,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/prostate-cancer-2.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-547705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/547705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=547705"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/547705\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/547706"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=547705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=547705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=547705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}