{"id":549879,"date":"2023-02-09T19:20:02","date_gmt":"2023-02-09T16:20:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/link-found-between-chronic-pain-and-overactive-pyramidal-neurons-during-sleep\/"},"modified":"2023-02-09T19:20:02","modified_gmt":"2023-02-09T16:20:02","slug":"link-found-between-chronic-pain-and-overactive-pyramidal-neurons-during-sleep","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/link-found-between-chronic-pain-and-overactive-pyramidal-neurons-during-sleep\/","title":{"rendered":"#Link found between chronic pain and overactive pyramidal neurons during sleep"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a348b95975b4\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a348b95975b4\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/link-found-between-chronic-pain-and-overactive-pyramidal-neurons-during-sleep\/#%E2%80%9CLink_found_between_chronic_pain_and_overactive_pyramidal_neurons_during_sleep%E2%80%9D\" >&#8220;Link found between chronic pain and overactive pyramidal neurons during sleep&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CLink_found_between_chronic_pain_and_overactive_pyramidal_neurons_during_sleep%E2%80%9D\"><\/span>&#8220;Link found between chronic pain and overactive pyramidal neurons during sleep&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/link-found-between-chr.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/link-found-between-chr.jpg\" data-sub-html=\"Silencing S1 VIP INs during sleep prevents persistent ongoing pain after SNI. a, Schematic of experimental timeline and the conditioned place preference (CPP) test. Two weeks after viral infection, mice were subjected to SNI and daily inhibition of the target cells in the sleep or wake phase for 5 days. CPP tests were performed 2\u20133 weeks after the last inhibition session. b, Representative heat maps showing time spent in CPP chambers. c, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095, 5, 5, 6 mice; saline vs. lidocaine, P\u2009=\u20090.87, 0.0004, 0.0001, 0.90; related to Fig. 2d). d, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096, 6, 6, 5, 5, 4 mice; saline vs. lidocaine, P\u2009=\u20090.81, 0.0035, 0.0063, 0.18, 0.74, 0.058; related to Fig. 2f). e, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095 mice per group, saline vs. lidocaine, P\u2009=\u20090.91, 0.0022, 0.019, 0.66; related to Fig. 5e). f, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20094, 5, 4, 5 mice; saline vs. lidocaine, P\u2009=\u20090.36, 0.012, 0.011, 0.12; related to Fig. 6e). g, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096 mice per group; saline vs. lidocaine, P\u2009=\u20090.11, 0.0010, 0.97, 0.49; related to Fig. 7b). Inset, experimental timeline. Mean \u00b1 s.e.m. *P\u2009&lt;\u20090.05, **P\u2009&lt;\u20090.01, ***P\u2009&lt;\u20090.001, ****P\u2009&lt;\u20090.0001; NS, not significant; by two-sided paired t-test. Credit: &lt;i&gt;Nature Neuroscience&lt;\/i&gt; (2023). DOI: 10.1038\/s41593-022-01250-y\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/link-found-between-chr.jpg\" alt=\"Link found between chronic pain and overactive pyramidal neurons during sleep\" title=\"Silencing S1 VIP INs during sleep prevents persistent ongoing pain after SNI. a, Schematic of experimental timeline and the conditioned place preference (CPP) test. Two weeks after viral infection, mice were subjected to SNI and daily inhibition of the target cells in the sleep or wake phase for 5 days. CPP tests were performed 2\u20133 weeks after the last inhibition session. b, Representative heat maps showing time spent in CPP chambers. c, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095, 5, 5, 6 mice; saline vs. lidocaine, P\u2009=\u20090.87, 0.0004, 0.0001, 0.90; related to Fig. 2d). d, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096, 6, 6, 5, 5, 4 mice; saline vs. lidocaine, P\u2009=\u20090.81, 0.0035, 0.0063, 0.18, 0.74, 0.058; related to Fig. 2f). e, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095 mice per group, saline vs. lidocaine, P\u2009=\u20090.91, 0.0022, 0.019, 0.66; related to Fig. 5e). f, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20094, 5, 4, 5 mice; saline vs. lidocaine, P\u2009=\u20090.36, 0.012, 0.011, 0.12; related to Fig. 6e). g, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096 mice per group; saline vs. lidocaine, P\u2009=\u20090.11, 0.0010, 0.97, 0.49; related to Fig. 7b). Inset, experimental timeline. Mean \u00b1 s.e.m. *P\u2009 Nature Neuroscience  (2023). DOI: 10.1038\/s41593-022-01250-y\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Silencing S1 VIP INs during sleep prevents persistent ongoing pain after SNI. a, Schematic of experimental timeline and the conditioned place preference (CPP) test. Two weeks after viral infection, mice were subjected to SNI and daily inhibition of the target cells in the sleep or wake phase for 5 days. CPP tests were performed 2\u20133 weeks after the last inhibition session. b, Representative heat maps showing time spent in CPP chambers. c, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095, 5, 5, 6 mice; saline vs. lidocaine, P\u2009=\u20090.87, 0.0004, 0.0001, 0.90; related to Fig. 2d). d, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096, 6, 6, 5, 5, 4 mice; saline vs. lidocaine, P\u2009=\u20090.81, 0.0035, 0.0063, 0.18, 0.74, 0.058; related to Fig. 2f). e, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20095 mice per group, saline vs. lidocaine, P\u2009=\u20090.91, 0.0022, 0.019, 0.66; related to Fig. 5e). f, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20094, 5, 4, 5 mice; saline vs. lidocaine, P\u2009=\u20090.36, 0.012, 0.011, 0.12; related to Fig. 6e). g, Time spent in the saline- and lidocaine-paired chambers for individual mice (n\u2009=\u20096 mice per group; saline vs. lidocaine, P\u2009=\u20090.11, 0.0010, 0.97, 0.49; related to Fig. 7b). Inset, experimental timeline. Mean \u00b1 s.e.m. *P\u2009Nature Neuro<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a> (2023). DOI: 10.1038\/s41593-022-01250-y<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A team of neuroscientists at the New York University School of Medicine has found a link between chronic pain and overactive pyramidal neurons during sleep periods. In their study, published in the journal <i>Nature Neuroscience,<\/i> the group conducted experiments with injured mice experiencing chronic pain.\n                                                <\/p>\n<p>Prior research has shown that there is often a link between chronic pain and insomnia. After experiencing a neural injury of some sort, many patients are left with some degree of lasting pain. This tends to result in poor sleep and sometimes insomnia. Once that h<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ens, the pain becomes worse, and over time becomes chronic. But why this happens has been a mystery. In this new effort, the team in New York conducted experiments with mice hoping to find the answer.<\/p>\n<p>The work involved inducing chronic pain in mice by damaging two of the three branches that make up a group of sciatic nerves. Doing so led to skin sensitivity in the legs. The researchers scanned the brains of each of the mice before and after the damage. They observed that pyramidal neurons in the part of the cerebral cortex responsible for sensation processing in the skin became more active. And over the course of several weeks, the activity increased, peaking during non-REM sleep.<\/p>\n<p>Additionally, the researchers found that the increased activity in the neurons was being controlled by the anterior nucleus basalis, which is located in a front portion of the brain\u2014it, too, became more active after the injury. This sent chemical signals to the pyramidal neurons, pushing them into an overexcited state. This led to increased skin sensitivity in the mice and more pain. Blocking the activity of the anterior nucleus basalis resulted in reduction in sensitivity and pain.<\/p>\n<p>It is not yet known if chronic pain works the same in humans, but the team plans to carry on their work to find out\u2014they also have begun work to find out if other types of chronic pain work the same way in mice.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Hang Zhou et al, A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain, <i>Nature Neuroscience<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41593-022-01250-y\">DOI: 10.1038\/s41593-022-01250-y<\/a><\/p><\/div>\n<p class=\"article-main__note mt-4\">\n                                                \u00a9 2023 Science X Network<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Link found between chronic pain and overactive pyramidal neurons during sleep (2023, February 9)<br \/>\n                                                 retrieved 9 February 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-02-link-chronic-pain-overactive-pyramidal.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Two weeks after viral infection, mice were subjected to SNI and daily inhibition of the target cells in the sleep&#8230;<\/p>\n","protected":false},"author":1,"featured_media":549880,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/link-found-between-chr.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-549879","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/549879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=549879"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/549879\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/549880"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=549879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=549879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=549879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}