{"id":559654,"date":"2023-03-03T22:24:26","date_gmt":"2023-03-03T19:24:26","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/unveiling-the-non-canonical-functions-of-ezh2-in-prostate-cancer\/"},"modified":"2023-03-03T22:24:26","modified_gmt":"2023-03-03T19:24:26","slug":"unveiling-the-non-canonical-functions-of-ezh2-in-prostate-cancer","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/unveiling-the-non-canonical-functions-of-ezh2-in-prostate-cancer\/","title":{"rendered":"#Unveiling the non-canonical functions of EZH2 in prostate cancer"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a407e834a71b\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a407e834a71b\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/unveiling-the-non-canonical-functions-of-ezh2-in-prostate-cancer\/#%E2%80%9CUnveiling_the_non-canonical_functions_of_EZH2_in_prostate_cancer%E2%80%9D\" >&#8220;Unveiling the non-canonical functions of EZH2 in prostate cancer&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CUnveiling_the_non-canonical_functions_of_EZH2_in_prostate_cancer%E2%80%9D\"><\/span>&#8220;Unveiling the non-canonical functions of EZH2 in prostate cancer&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/prostate-cancer-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/prostate-cancer-2.jpg\" data-sub-html=\"Prostate cancer cells. Credit: NIH Image Gallery\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/prostate-cancer-2.jpg\" alt=\"prostate cancer\" title=\"Prostate cancer cells. Credit: NIH Image Gallery\" width=\"740\" height=\"444\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Prostate cancer cells. Credit: NIH Image Gallery<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A new editorial paper was published in <i>Oncotarget<\/i> titled  &#8220;Unveiling the non-canonical functions of EZH2 in prostate cancer.&#8221;<\/p>\n<p>Prostate cancer (PCa) is ranked as the second leading cause of cancer-related death among American men excluding skin cancer. In this new editorial, researchers Yang Yi, Yanqiang Li, Kaifu Chen, and Qi Cao from Northwestern University&#8217;s Feinberg School of Medicine discuss a well-known oncogenic driver in PCa: enhancer of zeste homolog 2 (EZH2)\u2014canonically known for the functions as the catalytic subunit of Polycomb Repressive Complex 2 (PRC2) that deposes histone H3 lysine 27 mono, di-, and tri-methylation (H3K27me1-3) and represses tran<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ion.<\/p>\n<p>&#8220;Although the oncogenic role of EZH2 mainly relies on its enzymatic activity and the PRC2, accumulating evidence suggests that targeting the lysine methyltransferase activity of EZH2 alone is ineffective in treating EZH2-dependent malignancies including PCa,&#8221; say the researchers.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\"><meta itemprop=\"name\" content=\"Unveiling the non-canonical functions of EZH2 in prostate cancer\"\/><meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=9a13E8fhZaw\"\/><meta itemprop=\"description\" content=\"Credit: Impact Journals LLC\"\/><meta itemprop=\"uploadDate\" content=\"2023-03-03T12:16:50-05:00\"\/><meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/9a13E8fhZaw\"\/><meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/9a13E8fhZaw\/maxresdefault.jpg\"\/><br \/>\n             <iframe loading=\"lazy\" title=\"Unveiling the Non-Canonical Functions of EZH2 in Prostate Cancer | Oncotarget\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/9a13E8fhZaw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">Credit: Impact Journals LLC<\/figcaption><\/figure>\n<p>Hence, deeply investigating the multifaceted tumorigenic functions of EZH2 will shed new light on understanding the etiology of PCa. It is noteworthy that two recent studies published in <i>Nature Cell Biology<\/i> and <i>Oncogene<\/i> by Yi et al. described previously unrecognized roles of EZH2 in regulation of translation and coactivation of transcription, respectively. In both cases, EZH2 exerts oncogenic functions independently of PRC2 and H3K27me3 to promote tumorigenesis and aggressiveness in PCa.<\/p>\n<p>&#8220;In summary, both articles by Yi et al. emphasized the significance of non-canonical functions of EZH2 during PCa development, which may provide novel insights into the advancement of EZH2-targeting strategies to treat PCa patients. In fact, a new wave has been ushed for the discovery of EZH2 inhibitors to eliminate both the catalytic and non-catalytic activities of EZH2. Will these newly developed EZH2 degraders be successfully applied in PCa therapy? Will additional noncanonical functions of EZH2 be characterized in the PCa model? Let&#8217;s eagerly wait and see,&#8221; note the researchers.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                    <strong>More information:<\/strong><br \/>\n                                                    Yang Yi et al, Unveiling the non-canonical functions of EZH2 in prostate cancer, <i>Oncotarget<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.18632\/oncotarget.28357\">DOI: 10.18632\/oncotarget.28357<\/a><\/p><\/div>\n<p>                                                Provided by<br \/>\n                                                                                                    Impact Journals LLC<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Unveiling the non-canonical functions of EZH2 in prostate cancer (2023, March 3)<br \/>\n                                                 retrieved 4 March 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-03-unveiling-non-canonical-functions-ezh2-prostate.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: NIH Image Gallery A new editorial paper was published in Oncotarget titled &#8220;Unveiling the non-canonical functions of EZH2 in prostate cancer.&#8221; Prostate cancer (PCa) is ranked as the second leading cause of cancer-related death among American men excluding skin cancer. 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