{"id":56175,"date":"2020-08-29T00:58:00","date_gmt":"2020-08-28T21:58:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/hiv-patients-with-powerful-immune-systems-may-naturally-clear-infections-study-says\/"},"modified":"2020-08-29T00:58:00","modified_gmt":"2020-08-28T21:58:00","slug":"hiv-patients-with-powerful-immune-systems-may-naturally-clear-infections-study-says","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/hiv-patients-with-powerful-immune-systems-may-naturally-clear-infections-study-says\/","title":{"rendered":"#HIV patients with \u2018powerful immune systems\u2019 may naturally clear infections, study says"},"content":{"rendered":"

“#HIV patients with \u2018powerful immune systems\u2019 may naturally clear infections, study says<\/strong>”<\/p>\n

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August 28, 2020 |<\/span> 5:58pm <\/p>\n

\n A small percentage of\u00a0HIV patients may naturally reach a \u201cfunctional cure,\u201d isolating the virus into parts of the human genome so remote, it is unable to replicate, according to\u00a0new research.<\/p>\n

The only other known cure offering long-term HIV remission resulted from bone marrow transplants in two people. However, these transplants are risky, expensive\u00a0and not a realistic option for the estimated 38 million people with HIV infections worldwide.<\/p>\n

Last month, news<\/a> surfaced of a Brazilian man who might have cleared an HIV infection through a combination of antiretroviral drugs and nicotinamide to rout out the virus lingering in the HIV\u00a0reservoir\u00a0in the human genome. However, researchers have raised skepticism over those preliminary findings, saying it is too soon to tell.<\/p>\n

In the current study, published on Wednesday in Nature, researchers from the Ragon Institute of MGH, MIT and Harvard, among other institutions, discussed how they used\u00a0\u201cnext-generation sequencing\u201d to show how less than 0.5% of HIV infected people can naturally control the virus\u2019 replication, without the use of any drugs or risky surgery.<\/p>\n

This very small percentage of patients, called\u00a0\u201celite controllers,\u201d\u00a0can stifle the virus to, what researchers coin, the \u201cgene desert.\u201d Due to elite controllers\u2019 powerful immune systems,\u00a0the virus \u201chides\u201d in remote spots in the genome, far away from machinery that human genes use to produce proteins,\u00a0Dr. Xu Yu, study senior author and researcher at the Ragon Institute, explained to Fox News.<\/p>\n

Yu said the HIV virus is\u00a0\u201cvery smart to use human machinery to reproduce themselves.\u201d<\/p>\n

Other HIV patients may take antiretroviral therapy (ART) drugs, sometimes\u00a0for more than 20 years, but Yu said that\u00a0the new, advanced sequencing technology<\/a> can be used to analyze these patients\u2019 viral\u00a0profiles to see when they reach a state similar to that seen in\u00a0elite controllers, so they can stop\u00a0treatment and live healthy lives.<\/p>\n

Researchers analyzed 1.5 billion blood cells from one HIV patient, 66-year-old Loreen Willenberg of California, which detected the virus, albeit it was defected and not intact, or unable to give rise to new virus, Yu said.<\/p>\n

However, millions of cells from\u00a0the woman\u2019s digestive system did not detect any virus. Despite the comprehensive analysis using several complementary technologies, Yu says the team can \u201cnever reach the truth\u201d and say the patient is \u201cabsolutely cured\u201d of HIV unless every cell in her body is analyzed to detect for the virus.<\/p>\n

Another 63 patients in the study reportedly controlled their HIV infections without medications either, also potentially reaching a \u201cfunctional cure\u201d, per the New York Times.<\/p>\n

\u201cWhat we are hoping now to learn from these studies how do we enhance the immune responses from other patients so they can reach the same status [as elite controllers],\u201d Yu said. \u201cWe do not need to eliminate every single virus from the human genome in order to achieve a functional cure to HIV.\u201d\n <\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n

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Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

“#HIV patients with \u2018powerful immune systems\u2019 may naturally clear infections, study says” August 28, 2020 | 5:58pm A small percentage of\u00a0HIV patients may naturally reach a \u201cfunctional cure,\u201d isolating the virus into parts of the human genome so remote, it is unable to replicate, according to\u00a0new research. The only other known cure offering long-term HIV…<\/p>\n","protected":false},"author":1,"featured_media":56176,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[1],"tags":[60824,9724],"class_list":["post-56175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","tag-hiv-patients-with-powerful-immune-systems-may-naturally-clear-infections","tag-study-says"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/56175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=56175"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/56175\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/56176"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=56175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=56175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=56175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}