{"id":562301,"date":"2023-03-10T23:07:02","date_gmt":"2023-03-10T20:07:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/looking-for-risky-viruses-now-to-get-ahead-of-future-pandemics\/"},"modified":"2023-03-10T23:07:02","modified_gmt":"2023-03-10T20:07:02","slug":"looking-for-risky-viruses-now-to-get-ahead-of-future-pandemics","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/looking-for-risky-viruses-now-to-get-ahead-of-future-pandemics\/","title":{"rendered":"#Looking for risky viruses now to get ahead of future pandemics"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3c8213b32c1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3c8213b32c1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/looking-for-risky-viruses-now-to-get-ahead-of-future-pandemics\/#%E2%80%9CLooking_for_risky_viruses_now_to_get_ahead_of_future_pandemics%E2%80%9D\" >&#8220;Looking for risky viruses now to get ahead of future pandemics&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CLooking_for_risky_viruses_now_to_get_ahead_of_future_pandemics%E2%80%9D\"><\/span>&#8220;Looking for risky viruses now to get ahead of future pandemics&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/looking-for-risky-viru.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/looking-for-risky-viru.jpg\" data-sub-html=\"\u201cRepeat offender\u201d virus families that may pose higher risk to humans include filoviruses like Ebola, seen in this image of the virus isolated from patient blood samples in Mali. Credit: National Institute of Allergy and Infectious Diseases\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/looking-for-risky-viru.jpg\" alt=\"Looking for risky viruses now to get ahead of future pandemics\" title=\"\u201cRepeat offender\u201d virus families that may pose higher risk to humans include filoviruses like Ebola, seen in this image of the virus isolated from patient blood samples in Mali. Credit: National Institute of Allergy and Infectious Diseases\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                \u201cRepeat offender\u201d virus families that may pose higher risk to humans include filoviruses like Ebola, seen in this image of the virus isolated from patient blood samples in Mali. Credit: National Institute of Allergy and Infectious Diseases<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Most of what scientists know about viruses in animals is the list of nucleotides that compose their genomic sequence\u2014which, while valuable, offers very few hints about a virus&#8217;s ability to infect humans.<\/p>\n<section class=\"article-banner first-banner ads-336x280\"><!-- \/4988204\/Phys_Story_InText_Box --><br \/>\n      <\/section>\n<p>Rather than let the next outbreak take the world by surprise, two virologists say in a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ade6985\"><i>Science<\/i><\/a> Perspective article published today (March 10, 2023) that the scientific community should invest in a four-part research framework to proactively identify animal viruses that might infect humans.<\/p>\n<p>&#8220;A lot of financial investment has gone into sequencing viruses in nature and thinking that from sequence alone we&#8217;ll be able to predict the next pandemic virus. And I think that&#8217;s just a fallacy,&#8221; said Cody Warren, assistant professor of veterinary bio<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>s at The Ohio State University and co-lead author of the article.<\/p>\n<p>&#8220;Experimental studies of animal viruses are going to be invaluable,&#8221; he said. &#8220;By measuring properties in them that are consistent with human infection, we can better identify those viruses that pose the greatest risk for zoonosis and then study them further. I think that&#8217;s a realistic way of looking at things that should also be considered.&#8221;<\/p>\n<p>Warren co-authored the opinion piece with Sara Sawyer, professor of molecular, cellular and developmental biology at the University of Colorado Boulder.<\/p>\n<p>One key message Warren and Sawyer want to get across is that knowing an animal virus can attach to a human cell receptor doesn&#8217;t paint the whole picture of its zoonotic potential.<\/p>\n<p>They propose a <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/watch-movies-tv-seriess\/\" data-internallinksmanager029f6b8e52c=\"8\" title=\"Watch Movies &amp; TV Series\" target=\"_blank\" rel=\"noopener\">series<\/a> of experiments to assess an animal virus&#8217;s potential to infect a human: If it is found to enter human cells, can it use those host cells to make copies of itself and multiply? After viral particles are produced, can they get past human innate immunity? And have human immune systems ever been exposed to another virus from the same family?<\/p>\n<p>Answering these questions could enable scientists to put a pre-zoonotic candidate virus &#8220;on the shelf&#8221; for further research\u2014perhaps developing a quick way to diagnose the virus in humans if an unattributable illness surfaces and testing existing antivirals as possible treatments, Warren said.<\/p>\n<p>&#8220;Where it becomes difficult is that there may be many animal viruses out there with signatures of human compatibility,&#8221; he said. &#8220;So which ones do you pick and choose to prioritize for further study? That&#8217;s something that needs to be carefully considered.&#8221;<\/p>\n<p>A decent starting point, he and Sawyer suggest, would be operating on the assumption that viruses with the most risk to humans come from &#8220;repeat offender&#8221; viral families currently infecting mammals and birds. Those include coronaviruses, orthomyxoviruses (influenza) and filoviruses (causing hemorrhagic diseases like Ebola and Marburg). In 2018, the Bombali virus\u2014a new ebolavirus\u2014was detected in bats in Sierra Leone, but its potential to infect humans remains unknown.<\/p>\n<p>And then there are arteriviruses, such as the simian hemorrhagic fever virus that exists in wild African monkeys, which Sawyer and Warren <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/medicalxpress.com\/news\/2022-09-monkey-virus-poised-spillover-humans.html\">recently determined<\/a> has decent potential to spill over to humans because it can replicate in human cells and subvert immune cells&#8217; ability to fight back.<\/p>\n<p>The 2020 worldwide lockdown to prevent the spread of COVID-19 is still a fresh and painful memory, but Warren notes that the terrible outcomes of the emergence of SARS-CoV-2 could have been much worse. The availability of vaccines within a year of that lockdown was possible only because scientists had spent decades studying coronaviruses and knew how to attack them.<\/p>\n<p>&#8220;So if we invest in studying animal viruses early and understand their biology in more detail, then in the case that they were to emerge in humans later, we&#8217;d be better poised to combat them,&#8221; Warren said.<\/p>\n<p>&#8220;We are continually going to be exposed to the viruses of animals. Things are never going to change if we stay on the same trajectory,&#8221; he said. &#8220;And if we stay complacent and only study those animal viruses after they jump into humans, we&#8217;re constantly going to be working backwards. We&#8217;ll always be behind.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                        <strong>More information:<\/strong><br \/>\n                                                Cody J. Warren et al, Identifying animal viruses in humans, <i>Science<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/science.ade6985\">DOI: 10.1126\/science.ade6985<\/a>. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ade6985\">www.science.org\/doi\/10.1126\/science.ade6985<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium mt-4\">\n<p>                                                    Provided by<br \/>\n                                                                                                            Ohio State University<br \/>\n                                                                                                                <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.osu.edu\"><br \/>\n                                                            <svg><use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                <strong>Citation<\/strong>:<br \/>\n                                                Looking for risky viruses now to get ahead of future pandemics (2023, March 10)<br \/>\n                                                retrieved 11 March 2023<br \/>\n                                                from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-03-risky-viruses-future-pandemics.html<\/p>\n<p>                                             This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                             part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2023-03-risky-viruses-future-pandemics.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Looking for risky viruses now to get ahead of future pandemics&#8221; \u201cRepeat offender\u201d virus families that may pose higher risk to humans include filoviruses like Ebola, seen in this image of the virus isolated from patient blood samples in Mali. Credit: National Institute of Allergy and Infectious Diseases Most of what scientists know about viruses&#8230;<\/p>\n","protected":false},"author":1,"featured_media":562302,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/looking-for-risky-viru.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-562301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/562301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=562301"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/562301\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/562302"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=562301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=562301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=562301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}