{"id":565406,"date":"2023-03-17T23:24:59","date_gmt":"2023-03-17T20:24:59","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/senescence-associated-exosomes-transfer-fibrosis-to-neighboring-cells\/"},"modified":"2023-03-17T23:24:59","modified_gmt":"2023-03-17T20:24:59","slug":"senescence-associated-exosomes-transfer-fibrosis-to-neighboring-cells","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/senescence-associated-exosomes-transfer-fibrosis-to-neighboring-cells\/","title":{"rendered":"#Senescence-associated exosomes transfer fibrosis to neighboring cells"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a50b508e3e21\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a50b508e3e21\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/senescence-associated-exosomes-transfer-fibrosis-to-neighboring-cells\/#%E2%80%9CSenescence-associated_exosomes_transfer_fibrosis_to_neighboring_cells%E2%80%9D\" >&#8220;Senescence-associated exosomes transfer fibrosis to neighboring cells&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CSenescence-associated_exosomes_transfer_fibrosis_to_neighboring_cells%E2%80%9D\"><\/span>&#8220;Senescence-associated exosomes transfer fibrosis to neighboring cells&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/aging--senescence-asso.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2023\/aging--senescence-asso.jpg\" data-sub-html=\"Senescent EXO exchange promotes activated MSC phenotype. Credit: 2023 Lee et al.\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/aging--senescence-asso.jpg\" alt=\"Aging | Senescence-associated exosomes transfer fibrosis to neighboring cells\" title=\"Senescent EXO exchange promotes activated MSC phenotype. Credit: 2023 Lee et al.\" width=\"800\" height=\"457\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Senescent EXO exchange promotes activated MSC phenotype. Credit: 2023 Lee et al.<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A new research paper, titled &#8220;Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells,&#8221; was published in <i>Aging<\/i>.\n                                                <\/p>\n<p>Radiation-induced fibrosis is a common side effect of radiotherapy, which is the most common treatment for cancer. However, radiation also causes p53-<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>ted cell cycle arrest, prolonged expression of p21, and the development of senescence in normal cells that reside in irradiated tissues. Bone marrow-derived mesenchymal stem cells (MSCs) accumulate in primary tumor sites because of their natural tropism for inflammatory and fibrotic tissues.<\/p>\n<p>MSCs are extremely sensitive to low doses of ionizing radiation and acquire senescence as a result of bystander radiation effects. Senescent cells remain metabolically active but develop a potent senescence-associated secretory phenotype (SASP) that correlates to hyperactive secretion of cytokines, pro-fibrotic growth factors, and exosomes (EXOs).<\/p>\n<p>Integrative pathway analysis has highlighted that radiation-induced senescence significantly enriched cell-cycle, extracellular matrix, transforming growth factor-\u03b2 (TGF-\u03b2) signaling, and vesicle-mediated transport genes in MSCs. EXOs are cell-secreted nanovesicles (a subclass of small extracellular vesicles) that contain biomaterials\u2014proteins, RNAs, microRNAs (miRNAs)\u2014that are critical in cell-cell communication. miRNA content analysis of secreted EXOs further revealed that radiation-induced senescence uniquely altered miRNA profiles.<\/p>\n<p>&#8220;In fact, several of the standout miRNAs directly targeted TGF-\u03b2 or downstream genes,&#8221; write the researchers.<\/p>\n<p>In this new study, researchers Amy H. Lee, Deepraj Ghosh, Ivy L. Koh, and Michelle R. Dawson from Brown University further treated normal MSCs with senescence-associated EXOs (SA-EXOs) to examine bystander effects of radiation-induced senescence.<\/p>\n<p>The researchers found that these modulated genes were related to TGF-\u03b2 pathway and elevated both alpha smooth muscle actin (protein increased in senescent, activated cells) and Ki-67 (proliferative marker) expression in SA-EXO treated MSCs compared to untreated MSCs. They revealed that SA-EXOs possess unique miRNA content that influence myofibroblast phenotypes via TGF-\u03b2 pathway activation. This highlights that SA-EXOs are potent SASP factors that play a large role in cancer-related fibrosis.<\/p>\n<p>&#8220;Our integrated omics and EXO microarray analyses show that senescent MSCs possess differential tran<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ional genes and secrete vesicles that contain unique post-transcriptional cargo. We subsequently demonstrated that these EXO miRNAs can play important roles in cell-cell communication during disease progression,&#8221; conclude the authors.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Amy H. Lee et al, Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells, <i>Aging<\/i> (2023).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.18632\/aging.204539\">DOI: 10.18632\/aging.204539<\/a><\/p>\n<\/div>\n<p>\n                                                Provided by<br \/>\n                                                                                                    Impact Journals<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Study: Senescence-associated exosomes transfer fibrosis to neighboring cells (2023, March 17)<br \/>\n                                                 retrieved 18 March 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-03-senescence-associated-exosomes-fibrosis-neighboring-cells.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: 2023 Lee et al. A new research paper, titled &#8220;Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells,&#8221; was published in Aging. Radiation-induced fibrosis is a common side effect of radiotherapy, which is the most common treatment for cancer. However, radiation&#8230;<\/p>\n","protected":false},"author":1,"featured_media":565407,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2023\/aging--senescence-asso.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-565406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/565406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=565406"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/565406\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/565407"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=565406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=565406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=565406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}