{"id":589700,"date":"2023-09-03T17:20:02","date_gmt":"2023-09-03T14:20:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/concizumab-may-be-effective-prophylaxis-for-hemophilia-a-or-b-with-inhibitors\/"},"modified":"2023-09-03T17:20:02","modified_gmt":"2023-09-03T14:20:02","slug":"concizumab-may-be-effective-prophylaxis-for-hemophilia-a-or-b-with-inhibitors","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/concizumab-may-be-effective-prophylaxis-for-hemophilia-a-or-b-with-inhibitors\/","title":{"rendered":"#Concizumab may be effective prophylaxis for hemophilia A or B with inhibitors"},"content":{"rendered":"
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\"Concizumab<\/figure>\n<\/div>\n<\/div>\n

Patients with hemophilia A or B with inhibitors have a lower annualized bleeding rate with concizumab than with no prophylaxis, according to a phase 3 study published online Aug. 31 in the New England Journal of Medicine<\/i>.<\/p>\n

Tadashi Matsushita, M.D., Ph.D., from Nagoya University Hospital in Japan, and colleagues evaluated the safety and efficacy of concizumab in patients with hemophilia A or B with inhibitors. As part of the explorer7 phase 3 trial, participants were randomly assigned to receive no prophylaxis for at least 24 weeks (group 1; 19 patients) or to receive concizumab prophylaxis for at least 32 weeks (group 2; 33 patients), or they were nonrandomly assigned to receive concizumab prophylaxis for at least 24 weeks (groups 3 and 4; 81 patients).<\/p>\n

The researchers found that the estimated mean annualized bleeding rate in group 1 was 11.8 episodes versus 1.7 episodes in group 2 (rate ratio, 0.14; P “Concizumab represents a novel, subcutaneous treatment option in patients with hemophilia A or B with inhibitors that can potentially improve long-term outcomes,” the authors write.<\/p>\n

\n More information:<\/strong>
\n Tadashi Matsushita et al, Phase 3 Trial of Concizumab in Hemophilia with Inhibitors, New England Journal of Medicine<\/i> (2023). DOI: 10.1056\/NEJMoa2216455<\/a><\/p>\n

H. Marijke van den Berg et al, Hemostasis\u2014A Balancing Act, New England Journal of Medicine<\/i> (2023). DOI: 10.1056\/NEJMe2304535<\/a><\/p><\/div>\n

\n Copyright \u00a9 2023 HealthDay<\/a>. All rights reserved.<\/p>\n

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Citation<\/strong>:
\n Concizumab may be effective prophylaxis for hemophilia A or B with inhibitors (2023, September 3)
\n retrieved 3 September 2023
\n from https:\/\/medicalxpress.com\/news<\/a>\/2023-09-concizumab-effective-prophylaxis-hemophilia-inhibitors.html<\/p>\n

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