{"id":59531,"date":"2020-09-03T14:56:00","date_gmt":"2020-09-03T11:56:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/study-reveals-rna-g-quadruplex-structures-in-nature-for-the-first-time\/"},"modified":"2020-09-03T14:56:00","modified_gmt":"2020-09-03T11:56:00","slug":"study-reveals-rna-g-quadruplex-structures-in-nature-for-the-first-time","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/study-reveals-rna-g-quadruplex-structures-in-nature-for-the-first-time\/","title":{"rendered":"#Study reveals RNA G-quadruplex structures in nature for the first time"},"content":{"rendered":"

“#Study reveals RNA G-quadruplex structures in nature for the first time<\/strong>”<\/p>\n

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\"Study<\/img>
\n How\u00a0Arabidopsis plants grow slower when RNA G-quadruplex is folded. Credit: John Innes Centre
\n <\/figcaption><\/figure>\n<\/div>\n<\/div>\n

Researchers have resolved a longstanding biological debate by revealing the existence and function of complex RNA structures in plants.<\/p>\n

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RNA is often depicted in textbooks as linear and single stranded. But this macromolecule can fold into more complex shapes. RNA structures such as RNA G-quadruplexes, for example, have been seen in laboratory conditions forming in the presence of physiological concentration of potassium.<\/p>\n

Because of this, it has been suggested that these highly stable secondary structures have important biological relevance and must exist in nature. But until now there has been no direct evidence of RNA G-quadruplex formation in living cells.
\nIn a new study which app<\/a>ears in Genome Biology<\/i>, John Innes Center researchers investigated genetic regions rich in guanine one of the four main nucleobases found in DNA and RNA. These regions have in lab conditions shown potential to form RNA G-quadruplex motifs.
\nUsing chemical structure profiling researchers determined hundreds of RNA G-quadruplex structures strongly folded in the model species Arabidopsis and in rice\u2014providing the first direct evidence of RNA G-quadruplex formation in living eukaryotic cells.
\nSubsequent genetic and biochemical analysis showed that RNA G-quadruplex folding can regulate the fundamental biological process of translation from RNA to proteins and has a function in modulating plant growth.
\nCorresponding author Dr. Yiliang Ding says: “Our work over the past five years has tried to understand the structure of RNA inside the cell. For the first time we have answered the longstanding question about whether RNA G-quadruplex structures exist in living eukaryotic cells. Given that we have revealed the presence of a large number of RNA G-quadruplex structures in plants the next step is to unravel their individual regulatory roles in plant growth, development and stress response.”
\nThe study, “RNA G-quadruplex structures exist and function in vivo in plants’ appears in Genome Biology<\/i>.<\/p>\n

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More information:<\/strong>
\n Xiaofei Yang et al. RNA G-quadruplex structures exist and function in vivo in plants, Genome Biology<\/i> (2020). DOI: 10.1186\/s13059-020-02142-9\n <\/div>\n

\n Citation<\/strong>:
\n Study reveals RNA G-quadruplex structures in nature for the first time (2020, September 3)
\n retrieved 3 September 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-09-reveals-rna-g-quadruplex-nature.html<\/p>\n

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“#Study reveals RNA G-quadruplex structures in nature for the first time” How\u00a0Arabidopsis plants grow slower when RNA G-quadruplex is folded. Credit: John Innes Centre Researchers have resolved a longstanding biological debate by revealing the existence and function of complex RNA structures in plants. RNA is often depicted in textbooks as linear and single stranded. But…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[19211,63920],"class_list":["post-59531","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-plants-animals-molecular-computational-biology","tag-study-reveals-rna-g-quadruplex-structures-in-nature-for-the-first-time"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/59531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=59531"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/59531\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=59531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=59531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=59531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}