{"id":596471,"date":"2023-11-03T16:36:45","date_gmt":"2023-11-03T13:36:45","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/exploring-transcription-elongation-control-in-development-disease-and-aging\/"},"modified":"2023-11-03T16:36:45","modified_gmt":"2023-11-03T13:36:45","slug":"exploring-transcription-elongation-control-in-development-disease-and-aging","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/exploring-transcription-elongation-control-in-development-disease-and-aging\/","title":{"rendered":"#Exploring transcription elongation control in development, disease and aging"},"content":{"rendered":"
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\n Credit: Northwestern University
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In a recent article published<\/a> in Molecular Cell<\/i>, Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, and Yuki Aoi Ph.D., a postdoctoral fellow in Shilatifard laboratory, provided a comprehensive overview of the elongation stage of DNA transcript<\/a>ion, its central role in the regulation of gene expression and how its dysregulation is associated with developmental defects, disease and aging.<\/p>\n


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Transcription elongation, the process of synthesizing RNA from DNA, occurs when RNA polymerase II, a multiprotein complex, travel<\/a>s down a strand of DNA and copies genetic information from the DNA to RNA that is then converted into different proteins which fuel different cellular processes.<\/p>\n

The regulation of transcription elongation heavily relies on a variety of intracellular factors seamlessly working together, as research from the Shilatifard laboratory and others have shown over the last two decades.<\/p>\n

The connection between transcription elongation control and cancer was first discovered by Shilatifard in 1996 in a study published in Science<\/a><\/i>, which demonstrated for the first time that transcription elongation control is a key regulatory step in the proper regulation of gene expression. This fundamental finding laid the groundwork for subsequent research which has helped illuminate how its disruption causes different developmental defects, diseases and even contributes to the aging process.<\/p>\n

“What we showed almost 30 years ago is that elongation is a central regulatory step and that its misregulation can cause leukemia, and now we and others have shown how many different cellular processes use transcription elongation control as a key regulatory step,” Shilatifard said.<\/p>\n


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