{"id":597992,"date":"2023-11-17T13:00:01","date_gmt":"2023-11-17T10:00:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/first-comprehensive-guideline-on-using-biomarkers-for-monitoring-crohns-disease\/"},"modified":"2023-11-17T13:00:01","modified_gmt":"2023-11-17T10:00:01","slug":"first-comprehensive-guideline-on-using-biomarkers-for-monitoring-crohns-disease","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/first-comprehensive-guideline-on-using-biomarkers-for-monitoring-crohns-disease\/","title":{"rendered":"#First comprehensive guideline on using biomarkers for monitoring Crohn&#8217;s disease"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a414f7482352\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a414f7482352\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/first-comprehensive-guideline-on-using-biomarkers-for-monitoring-crohns-disease\/#About_Crohns_disease\" >About Crohn&#8217;s disease<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2017\/crohnsdisease.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2017\/crohnsdisease.jpg\" data-sub-html=\"High magnification micrograph of Crohn's disease. Biopsy of esophagus. H&amp;E stain. Credit: Nephron\/Wikipedia\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2017\/crohnsdisease.jpg\" alt=\"Crohn's disease\" title=\"High magnification micrograph of Crohn's disease. Biopsy of esophagus. H&amp;E stain. Credit: Nephron\/Wikipedia\" width=\"800\" height=\"480\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                High magnification micrograph of Crohn&#8217;s disease. Biopsy of esophagus. H&amp;E stain. Credit: Nephron\/Wikipedia<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>The American Gastroenterological Association (AGA) has released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn&#8217;s disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S.\n                                                <\/p>\n<p>The <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(23)05064-3\/fulltext\">guideline<\/a> was published today in <i>Gastroenterology<\/i>.<\/p>\n<p>Biomarkers are blood or stool tests that can give more information on an underlying disease process. In the context of IBD, biomarkers such as C-reactive protein (CRP) in blood and fecal calprotectin (FCP) in stool, can measure levels of inflammation. These levels can help doctors assess whether a patient&#8217;s Crohn&#8217;s disease is active or in remission.<\/p>\n<p>AGA recommends the use of biomarkers in addition to colonoscopy and imaging studies.<\/p>\n<p>&#8220;Patients&#8217; symptoms do not always match endoscopic findings, so biomarkers are a useful tool to understand and monitor the status of inflammation and guide decision making in patients with Crohn&#8217;s disease,&#8221; says guideline author Siddarth Singh, MD, MS, University of California, San Diego.<\/p>\n<p>For patients in remission:\n<\/p>\n<ul>\n<li>Check CRP and FCP every six to 12 months.<\/li>\n<li>These tests work best if CRP and FCP levels have previously matched with disease activity seen on endoscopic assessment.<\/li>\n<\/ul>\n<p>For patients experiencing active symptoms:\n<\/p>\n<ul>\n<li>Check CRP and FCP every two to four months for patients experiencing an increase in symptoms (diarrhea and abdominal pain) to guide treatment adjustments.<\/li>\n<li>Before making any major treatment plan changes, consider repeating endoscopic or radiologic assessments.<\/li>\n<\/ul>\n<p>For patients after surgery:\n<\/p>\n<ul>\n<li>FCP may be useful to monitor patients at low risk for disease recurrence.<\/li>\n<li>However, radiologic or endoscopic assessment should be performed when a post-operative recurrence is suspected rather than relying on biomarkers.<\/li>\n<\/ul>\n<p>&#8220;Based on this guideline, biomarkers are no longer considered experimental and should be an integral part of IBD care,&#8221; says guideline author Ashwin Ananthakrishnan, MBBS, MPH, Massachusetts <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">General<\/a> Hospital. &#8220;This is a win for Crohn&#8217;s disease patients. Biomarkers are usually easier to obtain, less invasive, more cost-effective than frequent colonoscopies and can be assessed more frequently for tighter disease control and better long-term outcomes in Crohn&#8217;s disease.&#8221;\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"About_Crohns_disease\"><\/span>About Crohn&#8217;s disease <span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Crohn&#8217;s disease is a chronic inflammatory condition that can affect any part of the digestive tract, from the mouth to the anus. It causes inflammation and damage to the digestive system, leading to symptoms such as abdominal pain, diarrhea, weight loss and fatigue and complications such as strictures and fistulas.<\/p>\n<p>Crohn&#8217;s disease is a lifelong condition with periods of active symptoms (flare-ups) and periods of remission when symptoms are less severe or absent. It can be diagnosed at any age but is most often diagnosed between ages 13 and 30. It can vary in severity and usually requires ongoing medical management to control symptoms and improve quality of life. Learn more in the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/patient.gastro.org\/crohns-disease\/\">AGA GI Patient Center.<\/a><\/p>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    American Gastroenterological Association<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.gastro.org\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 First comprehensive guideline on using biomarkers for monitoring Crohn&#8217;s disease (2023, November 17)<br \/>\n                                                 retrieved 17 November 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2023-11-comprehensive-guideline-biomarkers-crohn-disease.html<\/p>\n<p>                                            This document is subject to copyright. 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Biopsy of esophagus. H&amp;E stain. Credit: Nephron\/Wikipedia The American Gastroenterological Association (AGA) has released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn&#8217;s disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":597993,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2017\/crohnsdisease.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-597992","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/597992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=597992"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/597992\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/597993"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=597992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=597992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=597992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}