{"id":608054,"date":"2024-02-10T02:30:01","date_gmt":"2024-02-09T23:30:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-test-for-improving-population-based-colorectal-cancer-screening\/"},"modified":"2024-02-10T02:30:01","modified_gmt":"2024-02-09T23:30:01","slug":"new-test-for-improving-population-based-colorectal-cancer-screening","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-test-for-improving-population-based-colorectal-cancer-screening\/","title":{"rendered":"#New test for improving population-based colorectal cancer screening"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a38f903cd6a6\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a38f903cd6a6\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-test-for-improving-population-based-colorectal-cancer-screening\/#Three_proteins\" >Three proteins<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/new-test-for-improving-population-based-colorectal-cancer-screening\/#Cancer_precursors\" >Cancer precursors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/new-test-for-improving-population-based-colorectal-cancer-screening\/#More_true-positive_results\" >More true-positive results<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/cancer-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/cancer-2.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/cancer-2.jpg\" alt=\"cancer\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"529\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A new stool test <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ears to detect colorectal cancer precursors better than the current fecal immunochemical test. This could further reduce the number of new colorectal cancer cases as well as the number of people dying from the disease. A study led by the Netherlands Cancer Institute compared both tests.<\/p>\n<p>                                                                                                                                    Their results are <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/S1470-2045(23)00651-4\">published<\/a> in <i>The Lancet Oncology<\/i>.<\/p>\n<p>Each year worldwide, approximately 1.9 million people are diagnosed with colorectal cancer, and 935,000 people lose their lives as a result of the condition. If detected early, colorectal cancer is curable. However, by the time symptoms such as weight loss or blood in the stool appear, it is often too late. That is why many countries have introduced population-based screening programs. In The Netherlands, for example, people between the ages of 55 and 75 are invited to be tested every two years.<\/p>\n<p>Most population-wide screening programs use the fecal immunochemical test (FIT), a stool test that measures the presence of the blood protein hemoglobin. Worldwide, colorectal cancer screening programs have proven to be successful in diagnosing colorectal cancer at earlier stages and reducing colorectal cancer mortality.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Three_proteins\"><\/span>Three proteins<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;The current test performs well but leaves room for improvement,&#8221; says Gerrit Meijer, principal investigator at the Netherlands Cancer Institute. &#8220;We want to be able to detect the tumors before they have become invasive, that is at the stage of larger premalignant polyps. Treating physicians then can remove these polyps during a colonoscopy, rather than by surgery.&#8221;<\/p>\n<p>Meijer and his colleagues at the Netherlands Cancer Institute, the Amsterdam UMC and Erasmus MC have been working on a new test for years. This multitargetFIT-test (mtFIT) measures hemoglobin and two additional proteins. An earlier retrospective study demonstrated promising results.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Cancer_precursors\"><\/span>Cancer precursors<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Today, the researchers published the results of a much larger, prospective study that compared the mtFIT to the current FIT in over 13,000 participants of the Dutch national population-based screening program. The study was a success.<\/p>\n<p>&#8220;The new test can detect cancer precursors more effectively,&#8221; Meijer explains. &#8220;Our results predict that the test can reduce the number of new cases of colorectal cancer and mortality resulting from it.&#8221; For participants, the new test is just as easy to use as the current test.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"More_true-positive_results\"><\/span>More true-positive results<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The new test yielded more positive results than the current test. While this led to more colonoscopies, with the new mtFIT test, doctors found abnormalities in 299 persons, compared to 159 persons with the current FIT test. This difference mainly concerned persons with a high-risk precursor of colon cancer (216 versus 114). Meijer says, &#8220;The new test detects more larger polyps without a significant increase in &#8216;false-positive&#8217; results and thus unnecessary colonoscopies.&#8221;<\/p>\n<p>The exact number of colorectal cancer cases that could be prevented with this new test depends on the way the current FIT test is used in different countries.<\/p>\n<p>Meijer says, &#8220;The Dutch screening program applies a relatively high cutoff value to consider the FIT test positive, meaning unfavorable. Here, the new mtFIT test could lead to 21% fewer cases of colorectal cancer and 18% fewer mortalities. In countries that already use a lower FIT cutoff value, these figures would be lower, but likely at least 5% fewer people would develop colorectal cancer, with at least 4% fewer mortalities. In both scenarios, the new test could be cost-effective.&#8221;<\/p>\n<p>Implementation of mtFIT in existing FIT-based screening programs will be relatively easy because both tests basically require the same screening logistics.<\/p>\n<p>&#8220;This is exceptionally good <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>,&#8221; says Meijer. The new test cannot replace the current population screening test just yet. &#8220;The critical next step is to produce the test at an industrial scale according to European diagnostic test guidelines. To this end we founded the company CRCbioscreen, to enable the test to benefit CRC screening participants in the Netherlands and beyond.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                    <strong>More information:<\/strong><br \/>\n                                                    The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study, <i>The Lancet Oncology<\/i> (2024). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/S1470-2045(23)00651-4\">DOI: 10.1016\/S1470-2045(23)00651-4<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Netherlands Cancer Institute<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/www.nki.nl\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New test for improving population-based colorectal cancer screening (2024, February 9)<br \/>\n                                                 retrieved 9 February 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/news\/2024-02-population-based-colorectal-cancer-screening.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2024-02-population-based-colorectal-cancer-screening.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Pixabay\/CC0 Public Domain A new stool test appears to detect colorectal cancer precursors better than the current fecal immunochemical test. This could further reduce the number of new colorectal cancer cases as well as the number of people dying from the disease. A study led by the Netherlands Cancer Institute compared both tests. Their&#8230;<\/p>\n","protected":false},"author":1,"featured_media":608055,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/cancer-2.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-608054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/608054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=608054"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/608054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/608055"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=608054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=608054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=608054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}