{"id":608124,"date":"2024-02-10T17:00:02","date_gmt":"2024-02-10T14:00:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/triplet-therapy-including-belamaf-prolongs-survival-in-multiple-myeloma\/"},"modified":"2024-02-10T17:00:02","modified_gmt":"2024-02-10T14:00:02","slug":"triplet-therapy-including-belamaf-prolongs-survival-in-multiple-myeloma","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/triplet-therapy-including-belamaf-prolongs-survival-in-multiple-myeloma\/","title":{"rendered":"#Triplet therapy including belamaf prolongs survival in multiple myeloma"},"content":{"rendered":"
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For patients with relapsed or refractory multiple myeloma (RRMM), trip<\/a>let therapy of belantamab mafodotin (belamaf) plus bortezomib and dexamethasone (BVd) improves outcomes, with an acceptable safety profile, according to a study presented during the February 2024 session of the American Society for Clinical Oncology Plenary Series<\/a>.<\/p>\n

Maria-Victoria Mateos, Ph.D., from the Hospital Universitario de Salamanca in Spain, and colleagues conducted a randomized, phase III head-to-head trial to examine the efficacy and safety of BVd versus triplet standard-of-care therapy (daratumumab, bortezomib, and dexamethasone [DVd]) for patients with RRMM. A total of 494 patients with one or more prior lines of therapy were randomly allocated to BVd or DVd (243 and 251, respectively); the primary end point was independent review committee-assessed progression-free survival (PFS).<\/p>\n

The researchers found that the media<\/a>n PFS was 36.6 and 13.4 months in the BVd and DVd arms, respectively, after a median follow-up of 28.2 months (hazard ratio, 0.41). Overall survival data were 29 percent mature; median overall survival was not reached in either arm (hazard ratio, 0.57).<\/p>\n

The overall response rate was 82.7 and 71.3 percent for BVd and DVd, respectively. All patients experienced one or more adverse event; 90 and 67 percent of patients, respectively, in the BVd and DVd arms reported grade 3\/4 treatment-related adverse events, and 50 and 37 percent, respectively, reported serious adverse events.<\/p>\n

“The DREAMM-7 findings demonstrate that BVd improved outcomes for patients with relapsed or refractory multiple myeloma while also having a manageable safety profile,” Mateos said in a statement. “These results support BVd triplet therapy as a potential new standard of care option for these patients.”<\/p>\n

One author disclosed ties to pharmaceutical companies, including GlaxoSmithKline, which manufactures belamaf and funded the study.<\/p>\n

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