{"id":617053,"date":"2024-04-16T17:33:03","date_gmt":"2024-04-16T14:33:03","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/sustainable-synthesis-method-reveals-n-hydroxy-modifications-for-pharmaceuticals\/"},"modified":"2024-04-16T17:33:03","modified_gmt":"2024-04-16T14:33:03","slug":"sustainable-synthesis-method-reveals-n-hydroxy-modifications-for-pharmaceuticals","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/sustainable-synthesis-method-reveals-n-hydroxy-modifications-for-pharmaceuticals\/","title":{"rendered":"#Sustainable synthesis method reveals N-hydroxy modifications for pharmaceuticals"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2a88fb112f5\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2a88fb112f5\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/sustainable-synthesis-method-reveals-n-hydroxy-modifications-for-pharmaceuticals\/#Closing_knowledge_gaps%E2%80%94new_findings_on_heterocycles\" >Closing knowledge gaps\u2014new findings on heterocycles<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/sustainable-synthesis-method-reveals-n-hydroxy-modifications-for-pharmaceuticals\/#Potential_for_use_in_metabolic_research_and_pharmaceutical_research\" >Potential for use in metabolic research and pharmaceutical research<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2024\/sustainable-synthesis.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2024\/sustainable-synthesis.jpg\" data-sub-html=\"Credit: &lt;i&gt;Cell Reports Physical Science&lt;\/i&gt; (2024). DOI: 10.1016\/j.xcrp.2024.101927\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2024\/sustainable-synthesis.jpg\" alt=\"Sustainable synthesis method reveals N-hydroxy modifications for pharmaceuticals\" title=\"Credit: Cell Reports Physical Science (2024). DOI: 10.1016\/j.xcrp.2024.101927\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: <i>Cell Reports Physical <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a><\/i> (2024). DOI: 10.1016\/j.xcrp.2024.101927<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Recently published research results enable preparative access to novel substances that carry a modification of a structural motif frequently found in pharmaceuticals.<\/p>\n<section class=\"article-banner first-banner ads-336x280\"><!-- \/4988204\/Phys_Story_InText_Box --><br \/>\n      <\/section>\n<p>Sustainable chemical transformations are becoming increasingly important and in demand worldwide in all areas of life. Electrochemistry plays a decisive role in this development as electro-organic synthesis is a method that avoids large amounts of waste generated by conventional chemical transformations.<\/p>\n<p>In a recent paper, a team of scientists from the Max Planck Institute of Chemical Energy Conversion (MPI CEC) shows how electrochemistry is driving the development of more sustainable synthetic routes for the modern organic chemist&#8217;s toolkit by demonstrating that the electrochemical conversion of nitro groups, whose reduction normally requires large amounts of reductants or scarce metals, provides direct access to the previously understudied class of N-hydroxy heterocycles, an innovative structural motif for modern drug discovery.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Closing_knowledge_gaps%E2%80%94new_findings_on_heterocycles\"><\/span>Closing knowledge gaps\u2014new findings on heterocycles<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nitrogen-containing heterocycles, in particular, benzo[e]-1,2,4-thiadiazine-1,1-dioxides, are a widely used structural motif in modern blockbuster pharmaceuticals, like Diazoxide. In contrast, little is known about heterocycles containing an exocyclic N-hydroxy modification. The high stability and the unique characteristics of the N-O bond make this motif highly interesting for modern pharmaceutical research. In addition, N-oxy heterocycles are often found as major drug metabolites.<\/p>\n<p>Electrochemical synthesis by nitro reduction enables selective synthesis of this class of compounds, which is difficult to access by classical routes.<\/p>\n<p>Benzo[e]-1,2,4-thiadiazine-1,1-dioxides represent a structural motif found in multiple APIs. However, synthetic <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roaches to access N-hydroxy derivatives containing a unique exocyclic N-O modification have not been reported so far.<\/p>\n<p>Siegfried R. Waldvogel and his co-workers from MPI CEC and Johannes Gutenberg-Universit\u00e4t Mainz show in their recently published paper that electro-organic, a sustainable and powerful synthetic technique, enables highly selective and scalable access by cathodic reduction of easily accessible nitro arenes.<\/p>\n<p>The team of scientists developed a highly selective and scalable electro-organic synthesis of novel benzo[e]-1,2,4-thiadiazine-1,1-dioxides, which represents an important structural motif of APIs modified with a unique N-hydroxy moiety.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Potential_for_use_in_metabolic_research_and_pharmaceutical_research\"><\/span>Potential for use in metabolic research and pharmaceutical research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>This study has enabled preparative access to novel substances bearing an N-hydroxy modification of a structural motif commonly found in drugs and expanded the compound library of benzo[e]-1,2,4-thiadiazine-1,1-dioxides. However, the biological properties of these compounds are still completely unknown. Moreover, their investigation could help to improve the efficiency of drugs, to understand metabolism, or to explore new pharmaceutical applications.<\/p>\n<p>The paper is <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666386424001760\">published<\/a> in the journal <i>Cell Reports Physical Science<\/i>.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                        <strong>More information:<\/strong><br \/>\n                                                Johannes Winter et al, Highly selective scalable electrosynthesis of 4-hydroxybenzo[e]-1,2,4-thiadiazine-1,1-dioxides, <i>Cell Reports Physical Science<\/i> (2024). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.xcrp.2024.101927\">DOI: 10.1016\/j.xcrp.2024.101927<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium mt-4\">\n<p>                                                    Provided by<br \/>\n                                                                                                            Max-Planck-Institut f\u00fcr Chemische Energiekonversion<\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                <strong>Citation<\/strong>:<br \/>\n                                                Sustainable synthesis method reveals N-hydroxy modifications for pharmaceuticals (2024, April 16)<br \/>\n                                                retrieved 16 April 2024<br \/>\n                                                from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-04-sustainable-synthesis-method-reveals-hydroxy.html<\/p>\n<p>                                             This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                             part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2024-04-sustainable-synthesis-method-reveals-hydroxy.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Cell Reports Physical Science (2024). DOI: 10.1016\/j.xcrp.2024.101927 Recently published research results enable preparative access to novel substances that carry a modification of a structural motif frequently found in pharmaceuticals. Sustainable chemical transformations are becoming increasingly important and in demand worldwide in all areas of life. Electrochemistry plays a decisive role in this development as&#8230;<\/p>\n","protected":false},"author":1,"featured_media":617054,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2024\/sustainable-synthesis.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-617053","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/617053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=617053"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/617053\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/617054"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=617053"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=617053"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=617053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}