{"id":623535,"date":"2024-06-08T17:50:01","date_gmt":"2024-06-08T14:50:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/can-alzheimers-really-be-reversed-as-a-new-documentary-claims\/"},"modified":"2024-06-08T17:50:01","modified_gmt":"2024-06-08T14:50:01","slug":"can-alzheimers-really-be-reversed-as-a-new-documentary-claims","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/can-alzheimers-really-be-reversed-as-a-new-documentary-claims\/","title":{"rendered":"#Can Alzheimer&#8217;s really be reversed, as a new documentary claims?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3ac42e62045\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3ac42e62045\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/can-alzheimers-really-be-reversed-as-a-new-documentary-claims\/#Remarkable_improvements\" >Remarkable improvements<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/alzheimer-1.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/alzheimer-1.jpg\" data-sub-html=\"Credit: Unsplash\/CC0 Public Domain\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/alzheimer-1.jpg\" alt=\"Alzheimer\" title=\"Credit: Unsplash\/CC0 Public Domain\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Unsplash\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Two people diagnosed with Alzheimer&#8217;s claim to have conquered the disease through simple lifestyle changes.<\/p>\n<p>Dementia and Alzheimer&#8217;s have been the leading killers in the UK for the last ten years, accounting for 11.4% of deaths in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/articles\/deathregistrationsummarystatisticsenglandandwales\/2022#:~:text=The%20leading%20cause%20of%20death,10.4%25%20of%20all%20deaths\">2022<\/a>. Although <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzheimers.org.uk\/blog\/three-promising-drugs-for-treating-alzheimers-disease-bring-fresh-hope\">new drugs<\/a> can reduce the disease&#8217;s progression, more evidence is emerging that something as simple as integrating a healthy lifestyle can &#8220;reverse&#8221; symptoms of Alzheimer&#8217;s.<\/p>\n<p>Alzheimer&#8217;s disease can be split in two subgroups, familial and sporadic. Only 5% of patients with Alzheimer&#8217;s are <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzforum.org\/early-onset-familial-ad\/overview\/what-early-onset-familial-alzheimer-disease-efad\">familial<\/a>, inherited, and 95% of Alzheimer&#8217;s patients are <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4509477\/#:~:text=Apart%20from%20the%20gene%20polymorphisms,circulating%20proinflammatory%20cytokines%2C%20vitamin%20D\">sporadic<\/a>, due to environmental, lifestyle and genetic risk factors. Consequently, the most effective tactic for tackling Alzheimer&#8217;s is preventative and living a healthy lifestyle. This has led researchers to study risk factors associated with Alzheimer&#8217;s.<\/p>\n<p>Two Alzheimer&#8217;s sufferers, Cici Zerbe and Simon Nicholls, claim to have beaten the deadly disease with straightforward lifestyle changes. The pair have detailed their journey in a CNN documentary <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/edition.cnn.com\/2024\/05\/16\/health\/video\/gupta-alzheimers-reversed-patient-digvid#:~:text=In%20%E2%80%9CThe%20Last%20Alzheimer's%20Patient,impairment%20or%20early%20dementia%20due\">The Last Alzheimer&#8217;s Patient<\/a>.<\/p>\n<p>Zerbe experienced a reversal of symptoms after participating in a clinical trial in the US. The trial explores the effects of intensive lifestyle changes on mild cognitive impairment or early dementia due to Alzheimer&#8217;s disease. The study has not yet been published.<\/p>\n<p>Lifestyle changes include switching to a plant-based diet, regular exercise, group support sessions, yoga and meditation. Zerbe said that she feels &#8220;much better&#8221; than she did before taking part in the trial five years ago, when she was diagnosed with the disease.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Remarkable_improvements\"><\/span>Remarkable improvements<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Simon Nicholls, aged 55, is another person with Alzheimer&#8217;s who is featured in the CNN documentary and who took part in the trial. Nicholls carries two copies of a gene variant called <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nia.nih.gov\/news\/study-reveals-how-apoe4-gene-may-increase-risk-dementia\">ApoE4<\/a>, which is known to significantly increase the risk of Alzheimer&#8217;s. However, after adopting healthy lifestyle changes, Nicholls saw remarkable improvements in his symptoms.<\/p>\n<p>About 25% of the population carry at least one copy of the ApoE4 gene variant (called an &#8220;allele&#8221;) and 5% carry two <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nia.nih.gov\/health\/genetics-and-family-history\/alzheimers-disease-genetics-fact-sheet#:~:text=APOE%20%CE%B54%20increases%20risk%20for,to%205%25%20carry%20two%20copies.\">copies<\/a>. Carrying one ApoE4 allele is associated with a three to four times increased risk of developing Alzheimer&#8217;s. Carrying two copies increases the risk up to <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211383521003944\">12-fold<\/a> , rendering it the greatest genetic risk factor for Alzheimer&#8217;s.<\/p>\n<p>These statistics amplify the remarkable and noteworthy nature of Nicholls&#8217;s achievement in reversing his symptoms of Alzheimer&#8217;s simply through his lifestyle choices. His biomarkers for Alzheimer&#8217;s dis<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>eared in 14 months, which is considerably more effective than most treatments for Alzheimer&#8217;s.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\"><meta itemprop=\"name\" content=\"Can Alzheimer's really be reversed, as a new documentary claims?\"\/><meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=dS_cJferURA\"\/><meta itemprop=\"description\" content=\"Clip from CNN documentary on Alzheimer\u2019s.\"\/><meta itemprop=\"uploadDate\" content=\"2024-06-07T05:07:32-04:00\"\/><meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/dS_cJferURA\"\/><meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/dS_cJferURA\/maxresdefault.jpg\"\/><br \/>\n             <iframe loading=\"lazy\" title=\"How a Medical Mystery in Guam Led to a New Approach to Alzheimer\u2019s Disease\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/dS_cJferURA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">Clip from CNN documentary on Alzheimer\u2019s.<\/figcaption><\/figure>\n<p>Nicholls highlighted physical activity and dietary changes as paramount to his journey. At first, he was prescribed tirzepatide, a drug designed to suppress appetite by regulating blood sugar levels. He also incorporated regular exercise, including strength training three times a week, walking 10,000 steps daily and jogging or cycling every morning.<\/p>\n<p>                                                                                                                                            Cardiovascular disease is a major risk factor and potential future predictor of Alzheimer&#8217;s. The heart-brain connection is crucial for providing brain cells with energy and oxygen through cerebral blood flow. Thus, poor heart health could increase the risk of Alzheimer&#8217;s as brain cells receive less energy to function. This explains why Nicholls&#8217;s improved heart health and increased cardiovascular activity have improved his symptoms.<\/p>\n<p>He also enforced dietary changes\u2014removing sugar, alcohol and processed foods\u2014and embraced the Mediterranean diet.<\/p>\n<p>The Mediterranean diet is high in antioxidants, which protect brain cells from damage and research suggests the nutrients gained from the diet help maintain memory and cognitive skills. A recent extensive <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-023-02772-3\">study<\/a> on 60,000 Britons showed that adhering to a Mediterranean diet decreases the risk of dementia by 23%.<\/p>\n<p>Nicholls has also been implementing good sleep hygiene to try and improve his irregular sleep pattern, as some studies show that <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzheimers.org.uk\/about-dementia\/managing-the-risk-of-dementia\/possible-risks-of-dementia\/sleep#:~:text=Other%20research%20indicates%20that%20poor,the%20progression%20of%20Alzheimer's%20disease.\">sleep deprivation<\/a> is linked to Alzheimer&#8217;s.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<p>                                                                                                                                            The dominant theory is that during sleep toxic proteins, such as amyloid, can be flushed away with the glymphatic system. These would otherwise accumulate and cause dementia. Although, it should be noted that a recent <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41593-024-01638-y\">study in mice<\/a> draws this theory into question.<\/p>\n<p>Scientists from Imperial College London found that clearance of toxins was actually reduced during sleep, suggesting that sleep may reduce dementia risk through other mechanisms currently unknown.<\/p>\n<p>These lifestyle changes had significant effects on Nicholls&#8217;s life. In just nine weeks, he lost almost 10kg and 80% of his body fat and reduced his fasting blood sugar levels.<\/p>\n<p>Nicholls and Zerbe arguably did &#8220;reverse&#8221; their symptoms of Alzheimer&#8217;s. This is because conditions such as obesity, hypertension, cardiovascular disease, high cholesterol and insomnia are all risk factors for dementia, and can be modified through a healthy lifestyle.<\/p>\n<p>However, it is important to interpret these findings with caution. These are only results from two people on the trial. Without the specifics of the claimed results, it is difficult to determine whether these lifestyle choices have truly &#8220;reversed&#8221; the progression of the disease.<\/p>\n<p>The effect of lifestyle on cognition is gaining attention, with more scientists investigating the benefits. Combining the advent of new disease-modifying drugs with strict lifestyle changes may significantly reduce symptoms and the progression of Alzheimer&#8217;s.<\/p>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    The Conversation<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/theconversation.com\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                                                                                                            This article is republished from <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/can-alzheimers-really-be-reversed-as-a-new-documentary-claims-230705\">original article<\/a>.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/230705\/count.gif?distributor=republish-lightbox-advanced\" alt=\"The Conversation\" width=\"1\" height=\"1\"\/><\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Can Alzheimer&#8217;s really be reversed, as a new documentary claims? (2024, June 8)<br \/>\n                                                 retrieved 8 June 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-06-alzheimer-reversed-documentary.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2024-06-alzheimer-reversed-documentary.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Unsplash\/CC0 Public Domain Two people diagnosed with Alzheimer&#8217;s claim to have conquered the disease through simple lifestyle changes. Dementia and Alzheimer&#8217;s have been the leading killers in the UK for the last ten years, accounting for 11.4% of deaths in 2022. Although new drugs can reduce the disease&#8217;s progression, more evidence is emerging that&#8230;<\/p>\n","protected":false},"author":1,"featured_media":623536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/alzheimer-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-623535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/623535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=623535"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/623535\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/623536"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=623535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=623535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=623535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}