{"id":626172,"date":"2024-06-30T22:40:01","date_gmt":"2024-06-30T19:40:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/alzheimers-risk-higher-if-your-mother-had-cognitive-problems\/"},"modified":"2024-06-30T22:40:01","modified_gmt":"2024-06-30T19:40:01","slug":"alzheimers-risk-higher-if-your-mother-had-cognitive-problems","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/alzheimers-risk-higher-if-your-mother-had-cognitive-problems\/","title":{"rendered":"#Alzheimer&#8217;s risk higher if your mother had cognitive problems"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a30e68f4fb35\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a30e68f4fb35\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/alzheimers-risk-higher-if-your-mother-had-cognitive-problems\/#Developing_treatments\" >Developing treatments<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/alzheimers.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/alzheimers.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/alzheimers.jpg\" alt=\"alzheimers\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>The genetic risk of developing Alzheimer&#8217;s disease is more strongly influenced by the mother&#8217;s side than the father&#8217;s side, a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2820195\">recent study<\/a> has discovered.<\/p>\n<p>                                                                                                                                    Alzheimer&#8217;s disease steals memories, independence and the capacity to connect with loved ones. In 2020, over <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/#:~:text=Numbers%20of%20people%20with%20dementia&amp;text=There%20are%20over%2055%20million,and%20139%20million%20in%202050.\">55 million people<\/a> worldwide were living with dementia. Alzheimer&#8217;s disease is the most common form of dementia, accounting for <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia\">60-70%<\/a> of all dementias.<\/p>\n<p>It&#8217;s expected the number of people affected by dementia will nearly double every <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/\">20 years<\/a>. Finding ways to better diagnose, treat and even prevent dementia is more important than ever. This latest study could provide a useful target for researchers hoping to develop new therapies.<\/p>\n<p>The study, published in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/article-abstract\/2820195\"><i>JAMA Neurology<\/i><\/a>, showed that people whose mother had a history of memory loss had a greater risk of developing Alzheimer&#8217;s disease at any age when compared to people with only a paternal history of memory loss (or no family history of memory loss whatsoever). However, if a person&#8217;s father had early-onset memory loss (occurring before the age of 65), they also had a greater risk of Alzheimer&#8217;s disease.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<p>                                                                                                                                            The study analyzed data from 4,413 people aged 65 to 85 who had no issues with cognitive function or memory problems. The study&#8217;s large sample size is a key strength, making for a more accurate interpretation of the findings compared to previous research. But it&#8217;s important to note it&#8217;s not a complete representation of the population, as most participants were white\u2014so results may differ in other ethnicities.<\/p>\n<p>The participants were part of the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzheimers.gov\/clinical-trials\/anti-amyloid-treatment-asymptomatic-alzheimers-disease-a4\">Anti-Amyloid Treatment in Asymptomatic Alzheimer study<\/a>, which is a phase 3 clinical trial investigating a drug researchers hope will slow the progression of memory problems. The participants&#8217; cognitive function was measured using questions from the widely used <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mini-mental-state-examination\">mini-mental state examination<\/a>.<\/p>\n<p><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzheimers.org.uk\/research\/take-part-research\/pet-scan#:~:text=Positron%20Emission%20Tomography%20(PET)%20scans,key%20hallmarks%20of%20Alzheimer's%20disease.\">Positron emission tomography (PET)<\/a> imaging was also used to scan their brains for markers of Alzheimer&#8217;s disease and determine their risk of developing it.<\/p>\n<p>The researchers were mainly looking for the presence of amyloid plaques, which are one of two hallmarks of Alzheimer&#8217;s disease. These toxic amyloid plaques form when protein pieces, called beta-amyloid, clump together.<\/p>\n<p>                                                                                                                                            The hypothesis is that these clumped amyloid plaques are the prime suspects in damaging and killing brain cells (neurons), <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/nrd3505\">resulting in Alzheimer&#8217;s disease<\/a>. The second hallmark of Alzheimer&#8217;s is the protein tau, which wasn&#8217;t assessed in this study.<\/p>\n<p>The accumulation of beta-amyloid is thought to be a prominent precursor of Alzheimer&#8217;s disease, as people can have raised amyloid levels <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41380-021-01249-0\">years before<\/a> memory problems start.<\/p>\n<p>The results of the PET scans showed that participants whose mother had a history of memory impairment (regardless of the age her memory problems started) had higher beta-amyloid levels. The amyloid levels were significantly higher on average in those with maternal history than paternal history of memory impairment.<\/p>\n<p>Participants whose fathers had early-onset memory loss (occurring before 65) also had higher beta-amyloid levels. In comparison, participants who only had a paternal history of late-onset memory impairment (h<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ening after 65 years of age), and those who had no family history of memory loss, had normal beta-amyloid levels.<\/p>\n<p>The reason for this link is not completely understood.<\/p>\n<p>One suggestion from the researchers is mitochondria dysfunction. Mitochondria are energy-providing structures inside our cells. These are only inherited from the mother&#8217;s side. Mitochondria possess their own DNA, which may include mutations that cause them to malfunction. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9878959\/\">Previous research<\/a> has already demonstrated mitochondria dysfunction is associated with Alzheimer&#8217;s disease.<\/p>\n<p>The brain is an energy-hungry organ, taking up about <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ucl.ac.uk\/news\/2020\/aug\/energy-demands-limit-our-brains-information-processing-capacity\">20% of the body&#8217;s energy<\/a>. So it&#8217;s unsurprising that dysfunction in mitochondria could lead to cognitive impairment\u2014and potentially Alzheimer&#8217;s disease.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Developing_treatments\"><\/span>Developing treatments<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>This study builds on previous, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22669011\/\">smaller studies<\/a> which have investigated the role genetics play in Alzheimer&#8217;s disease. Since these studies only had small sample sizes, they lacked the statistical power to draw strong conclusions. This study&#8217;s much larger sample size allowed for stronger conclusions and reaffirmations on the importance of maternal genetics to be made.<\/p>\n<p>The key message from the study is that a person&#8217;s risk for Alzheimer&#8217;s disease could depend on whether they inherit it from their mother or father, as well as their parent&#8217;s age when memory loss began. As such, considering gender-specific parental history could be fundamental in identifying those at greatest risk of Alzheimer&#8217;s.<\/p>\n<p>In light of these findings, next steps could be to determine whether the DNA from the mother\u2014specifically the X chromosome itself\u2014influences the disease&#8217;s development. If it does play a role, then researchers may have a better target for treatment.<\/p>\n<p>And given mitochondria are inherited from the mother&#8217;s side, researchers may also want to further investigate the mitochondria dysfunction theory to better understand if this explains why people are at greater risk of developing Alzheimer&#8217;s disease if their mother had memory problems.<\/p>\n<p>This latest study confirms the critical role that genetics play in the development of Alzheimer&#8217;s disease. But it isn&#8217;t the only risk factor. Many <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.alzheimers.org.uk\/about-dementia\/types-dementia\/who-gets-alzheimers-disease\">modifiable risk factors<\/a>\u2014such as diabetes, high blood pressure, cardiovascular disease and poor diet\u2014are also known to be massive contributors to developing the disease.<\/p>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    The Conversation<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/theconversation.com\"><br \/>\n                                                        <svg><use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                                                                                                            This article is republished from <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/alzheimers-risk-higher-if-your-mother-had-cognitive-problems-233032\">original article<\/a>.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/233032\/count.gif?distributor=republish-lightbox-advanced\" alt=\"The Conversation\" width=\"1\" height=\"1\"\/><\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Alzheimer&#8217;s risk higher if your mother had cognitive problems (2024, June 30)<br \/>\n                                                 retrieved 30 June 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-06-alzheimer-higher-mother-cognitive-problems.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2024-06-alzheimer-higher-mother-cognitive-problems.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Pixabay\/CC0 Public Domain The genetic risk of developing Alzheimer&#8217;s disease is more strongly influenced by the mother&#8217;s side than the father&#8217;s side, a recent study has discovered. Alzheimer&#8217;s disease steals memories, independence and the capacity to connect with loved ones. In 2020, over 55 million people worldwide were living with dementia. Alzheimer&#8217;s disease is&#8230;<\/p>\n","protected":false},"author":1,"featured_media":626173,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/alzheimers.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-626172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/626172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=626172"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/626172\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/626173"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=626172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=626172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=626172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}