{"id":627437,"date":"2024-07-12T18:00:14","date_gmt":"2024-07-12T15:00:14","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead\/"},"modified":"2024-07-12T18:00:14","modified_gmt":"2024-07-12T15:00:14","slug":"new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead\/","title":{"rendered":"#New tool combines evolution and AI to predict prostate cancer recurrence more than a decade ahead"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a36ebc06a292\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a36ebc06a292\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead\/#Addressing_the_lack_of_predictive_markers_in_prostate_cancer\" >Addressing the lack of predictive markers in prostate cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead\/#Identifying_new_measurements\" >Identifying new measurements<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/new-tool-combines-evolution-and-ai-to-predict-prostate-cancer-recurrence-more-than-a-decade-ahead\/#%E2%80%98New_methods_such_as_ours_are_urgently_needed\" >&#8216;New methods such as ours are urgently needed&#8217;<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2024\/new-tool-combining-evo.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/new-tool-combining-evo.jpg\" data-sub-html=\"Study design. Credit: &lt;i&gt;Nature Cancer&lt;\/i&gt; (2024). DOI: 10.1038\/s43018-024-00787-0\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2024\/new-tool-combining-evo.jpg\" alt=\"New tool combining evolution and AI predicts prostate cancer recurrence more than a decade ahead\" title=\"Study design. Credit: Nature Cancer (2024). DOI: 10.1038\/s43018-024-00787-0\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Study design. Credit: <i>Nature Cancer<\/i> (2024). DOI: 10.1038\/s43018-024-00787-0<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Combining the principles of evolution with artificial intelligence (AI), scientists have proposed a new way to predict the chance of prostate cancer returning. In a recent study, they harnessed computational methods to capture specific tumor measurements relating to the tumor&#8217;s ability to change over time. They then showed that these measurements correlate with disease recurrence more than a decade after the initial diagnosis.<\/p>\n<p>                                                                                                                                    This <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach could help clinicians systematically categorize patients according to their risk of disease recurrence. Based on this, they may be able to determine which patients only need localized treatment\u2014typically radiotherapy, often alongside hormone therapy, or surgery\u2014and which should receive additional treatment.<\/p>\n<p>The study, led by researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, could ultimately help clinicians better personalize treatment for prostate cancer. The findings have been <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s43018-024-00787-0\">published<\/a> in <i>Nature Cancer<\/i>.<\/p>\n<p>This work also uniquely combined certain tumor measurements in an evolutionary way, further validating the application of an evolutionary biology model to cancer. Scientists at the Center for Evolution and Cancer at The Institute of Cancer Research (ICR) are at the forefront of cancer evolution research, which they are confident will lead to new effective treatments for multiple types of cancer.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Addressing_the_lack_of_predictive_markers_in_prostate_cancer\"><\/span>Addressing the lack of predictive markers in prostate cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>It is particularly difficult to predict outcomes in prostate cancer because the disease has extensive heterogeneity, meaning that there are significant differences between the cancerous cells\u2014both within each tumor and across patients. In addition, cancer often develops at more than one site within the prostate, producing two or more tumors in proximity. As a result, it is often difficult for clinicians to determine the best treatments for their patients.<\/p>\n<p>In some cases, clinicians can adopt a &#8220;watch-and-wait&#8221; approach, sparing a person from the side effects of treatment while it is not necessary. However, this strategy could prove fatal for people with aggressive cancer or cancer that is more likely to recur.<\/p>\n<p>Although other studies have evaluated the use of tumor measurements to predict outcomes, these used limited numbers of patient samples, only considered early-stage disease and were often not carried out in a clinical trial setting. In addition, they primarily included patients who had already undergone surgery to remove the cancer.<\/p>\n<p>Believing that treatment decisions should be made ahead of surgery instead, the team behind the new study set out to find a new way to predict tumor progression in people diagnosed with high-risk locally advanced prostate cancer.<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Identifying_new_measurements\"><\/span>Identifying new measurements<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The researchers used a form of AI called machine learning to analyze a total of 1,923 samples from 250 participants on the IMRT (intensity modulated radiotherapy) clinical trial, with a focus on the spatial tissue structure. They also used a purpose-built AI technique to perform Gleason grading\u2014a scoring system that grades cancerous tissue from one to five based on the pattern of its cells. Cancerous cells that look very similar to healthy cells are assigned grade 1 while those that look significantly different are assigned grade 5.<\/p>\n<p>At the same time, the researchers assessed the genetic differences between the cells within individual tumors, using 642 samples from 114 participants in radiotherapy trials at The Royal Marsden. These samples overlapped with the first set, providing the team with integrated information about the cells&#8217; genomics and morphology, as well as the patients&#8217; outcomes over more than a decade.<\/p>\n<p>The researchers found genetic divergence and AI-measured morphological diversity (the difference in the shape, size and structure of the cells) to be indicative of the tumor&#8217;s ability to evolve, which allows the disease to adapt and survive. They measured this diversity by looking at the extent of the differences between cells in different areas of the tumor, known as intra-tumor heterogeneity.<\/p>\n<p>The findings showed that this &#8220;evolvability&#8221; was a strong predictor of recurrence, with the combination of the two measurements identifying a subgroup of patients who experienced disease recurrence in half the length of time compared with the rest of the patients.<\/p>\n<p>The team was also able to identify a correlation between the loss of a specific chromosome and a reduced presence of immune cells in the tumor, which may affect its response to certain treatments. This additional information could further support better treatment decisions.<\/p>\n<p>The next step is for the researchers to test their evolution-based measurements of recurrence risk in a larger group of people with a broader range of disease characteristics. They will also need to factor in external factors, such as hormone levels.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E2%80%98New_methods_such_as_ours_are_urgently_needed\"><\/span>&#8216;New methods such as ours are urgently needed&#8217;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Joint first author Dr. George Cresswell, who was a Postdoctoral Research Fellow in the Genomics and Evolutionary Dynamics group at the ICR when the research was carried out, is now Principal Investigator at St. Anna Children&#8217;s Cancer Research Institute in Vienna, Austria.<\/p>\n<p>Cresswell said, &#8220;We are pleased to have found new measurements that can be taken from standard prostate cancer biopsies to predict the risk of recurrence in people with prostate cancer. Doctors don&#8217;t currently have specific enough ways to measure which patients have the lowest and highest risk of their cancer returning, meaning new methods such as ours are urgently needed.<\/p>\n<p>&#8220;Our work has also demonstrated the combined potential of evolutionary genomics and artificial intelligence to enhance our study of cancer tissues when we apply it in the context of clinical trials. We hope that this approach will accelerate our progress towards using evolutionary biomarkers in clinical practice for both prostate cancer and other types of cancer.&#8221;<\/p>\n<p>Joint senior author Professor David Dearnaley, Emeritus Professor at the ICR and retired Consultant Clinical Oncologist at The Royal Marsden, said, &#8220;This study shows the power of a combined approach in which we assess both genomics and spatial morphology.<\/p>\n<p>&#8220;We believe that our findings will make it possible to identify the patients with high-risk localized cancer who are most likely to benefit from early treatment with life-extending medications. Until now, we&#8217;ve not been able to separate out the patients who have the very highest risk of recurrence, but our novel analyses could change this by significantly improving our ability to predict whether cancer will return.&#8221;<\/p>\n<p>                                                                                                        <!-- Google middle Adsense block --><\/p>\n<p>                                                                                                                                            The other senior author, Professor Andrea Sottoriva, Professor of Cancer Genomics and Evolution at the ICR at the time of the research and now Head of the Computational Biology Research Center at Human Technopole in Milan, Italy, said, &#8220;It&#8217;s exciting that we have taken new measurements with innovative evolutionary interpretations that have never been shown before.<\/p>\n<p>&#8220;As well as producing better prognostic biomarkers for prostate cancer, our study serves as additional evidence that the evolutionary biology paradigm applied to cancer has a remarkable predictive power.<\/p>\n<p>&#8220;By applying a computational approach to multiple datasets, we have been able to decipher some of the dynamics of cancer progression and treatment resistance. This type of research is key to furthering our understanding of how and when to treat cancers, including prostate cancer.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                    <strong>More information:<\/strong><br \/>\n                                                    Javier Fernandez-Mateos et al, Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer, <i>Nature Cancer<\/i> (2024). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s43018-024-00787-0\">DOI: 10.1038\/s43018-024-00787-0<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Institute of Cancer Research<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.icr.ac.uk\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New tool combines evolution and AI to predict prostate cancer recurrence more than a decade ahead (2024, July 12)<br \/>\n                                                 retrieved 12 July 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-07-tool-combines-evolution-ai-prostate.html<\/p>\n<p>                                            This document is subject to copyright. 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Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2024-07-tool-combines-evolution-ai-prostate.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Study design. Credit: Nature Cancer (2024). DOI: 10.1038\/s43018-024-00787-0 Combining the principles of evolution with artificial intelligence (AI), scientists have proposed a new way to predict the chance of prostate cancer returning. In a recent study, they harnessed computational methods to capture specific tumor measurements relating to the tumor&#8217;s ability to change over time. They then&#8230;<\/p>\n","protected":false},"author":1,"featured_media":627438,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/new-tool-combining-evo.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-627437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/627437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=627437"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/627437\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/627438"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=627437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=627437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=627437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}