{"id":627857,"date":"2024-07-16T19:36:20","date_gmt":"2024-07-16T16:36:20","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/novel-protein-detects-and-responds-to-changes-in-blood-flow\/"},"modified":"2024-07-16T19:36:20","modified_gmt":"2024-07-16T16:36:20","slug":"novel-protein-detects-and-responds-to-changes-in-blood-flow","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/novel-protein-detects-and-responds-to-changes-in-blood-flow\/","title":{"rendered":"#Novel protein detects and responds to changes in blood flow"},"content":{"rendered":"
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\n Model for junctional endothelial shear stress mechanotransduction. Credit: The EMBO Journal<\/i> (2024). DOI: 10.1038\/s44318-024-00142-0
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When blood moves through your body, it exerts a frictional force on the walls of blood vessels. This force, known as fluid shear stress, has important effects on vascular development, function, and disease.<\/p>\n

A team at Yale, led by Martin Schwartz, Ph.D., Robert W. Berliner Professor of Medicine (cardiology), has identified a protein that helps your body sense and respond to changes in this shear stress. The study, “Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions,<\/a>” is published in The EMBO Journal<\/i>.<\/p>\n

This protein, latrophilin-2, is found on the surface of the cells lining the blood vessel wall. Schwartz’s team demonstrated that latrophilin-2 is activated by changes in blood flow and is required for flow-dependent blood vessel development and preclinical remodeling. Additionally, the authors found that specific variants of the gene encoding latrophilin-2 are highly associated with the development of cardiovascular disease in humans.<\/p>\n

These findings help define a novel pathway by which our blood vessels respond to changes in flow and shed new light on cell biology and genetic links to cardiovascular disease.<\/p>\n

\n More information:<\/strong>
\n Keiichiro Tanaka et al, Latrophilin-2 media<\/a>tes fluid shear stress mechanotransduction at endothelial junctions, The EMBO Journal<\/i> (2024). DOI: 10.1038\/s44318-024-00142-0<\/a><\/p><\/div>\n
\n Provided by
\n Yale University
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Citation<\/strong>:
\n Novel protein detects and responds to changes in blood flow (2024, July 16)
\n retrieved 16 July 2024
\n from https:\/\/medicalxpress.com\/news<\/a>\/2024-07-protein-blood.html<\/p>\n

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\n part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n