{"id":638492,"date":"2024-09-16T17:14:02","date_gmt":"2024-09-16T14:14:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/modified-nano-sized-cell-particles-found-to-boost-cancer-immunotherapy-reduce-side-effects\/"},"modified":"2024-09-16T17:14:02","modified_gmt":"2024-09-16T14:14:02","slug":"modified-nano-sized-cell-particles-found-to-boost-cancer-immunotherapy-reduce-side-effects","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/modified-nano-sized-cell-particles-found-to-boost-cancer-immunotherapy-reduce-side-effects\/","title":{"rendered":"#Modified nano-sized cell particles found to boost cancer immunotherapy, reduce side effects"},"content":{"rendered":"
\n
\n
\n
\n \"Modified
\n Electron micrograph of engineered extracellular vesicles at a magnification of 23,000\u00d7. Credit: NUS Yong Loo Lin School of Medicine
\n <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n

Immunotherapy is a type of cancer treatment that uses the body’s own immune system to help fight cancer. This is by stimulating the immune response to recognize and attack cancer cells more effectively. The treatment involves using substances that boost the immune system, teaching immune cells to target cancer, or using engineered cells to specifically target and kill cancer cells.<\/p>\n

While it is a key app<\/a>roach in cancer treatment, the effectiveness of immunotherapy is limited by the risk of immune-related side effects, because the immune system, while targeting cancer cells, may also attack normal, healthy tissues. These side effects include inflammation or damage to various organs and tissues, causing a range of symptoms or complications in health outcomes.<\/p>\n

A team led by Assistant Professor Minh Le from the Institute for Digital Medicine (WisDM) and Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) has unveiled a novel delivery platform that significantly enhances the effectiveness of cancer immunotherapy while reducing the associated side effects. This innovative approach, leveraging nano-sized particles released by cells, termed “extracellular vesicles” (EVs), represents a major advancement in the field of cancer immunotherapy.<\/p>\n

In the study, the researchers developed a technique which modified EVs to carry multiple immune-boosting molecules called “immunomodulatory ligands,” for the treatment of in vivo models of metastatic pancreatic cancer and melanoma. The approach enhanced the therapeutic effectiveness of the ligands\u2014particularly the subset Tumor Necrosis Factor Receptor Superfamily (TNFRSF) agonists, which are key in controlling immune responses against cancer.<\/p>\n

The team also found that the delivery method enhanced retention of the immune-boosting ligands in the tumor\u2014allowing for better therapeutic effects to be achieved with lower drug doses, which in turn reduced the risk of side effects that are often seen in current immunotherapeutic treatments.<\/p>\n

Published<\/a> in Molecular Therapy<\/i>, the study demonstrates that the new EV-based delivery approach can alter the tumor’s immune composition to improve treatment outcomes of patients with cancer.<\/p>\n