{"id":642094,"date":"2024-10-21T18:29:04","date_gmt":"2024-10-21T15:29:04","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/study-reveals-new-role-for-inflammatory-protein-in-fat-tissue\/"},"modified":"2024-10-21T18:29:04","modified_gmt":"2024-10-21T15:29:04","slug":"study-reveals-new-role-for-inflammatory-protein-in-fat-tissue","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/study-reveals-new-role-for-inflammatory-protein-in-fat-tissue\/","title":{"rendered":"#Study reveals new role for inflammatory protein in fat tissue"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3707a1f2793\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3707a1f2793\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/study-reveals-new-role-for-inflammatory-protein-in-fat-tissue\/#Significance_of_the_results_and_future_research\" >Significance of the results and future research<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2024\/study-reveals-new-role.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/study-reveals-new-role.jpg\" data-sub-html=\"Microscope image of fat cells. Credit: Kaisa Hofwimmer\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2024\/study-reveals-new-role.jpg\" alt=\"Study reveals new role for inflammatory protein in fat tissue\" title=\"Microscope image of fat cells. Credit: Kaisa Hofwimmer\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Microscope image of fat cells. Credit: Kaisa Hofwimmer<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A new study <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-51938-x\">published<\/a> in <i>Nature Communications<\/i> shows that the inflammatory protein IL-1\u03b2 has an important physiological function in fat tissue. Researchers at Karolinska Institutet have discovered that IL-1\u03b2 helps the body manage energy storage by signaling cells to transform into new fat cells that can safely store energy.<\/p>\n<p>                                                                                                                                    The study shows that IL-1\u03b2, which is usually associated with negative inflammatory effects, has a previously unknown function in healthy energy storage.<\/p>\n<p>&#8220;This may have implications for the development of new therapeutic treatments that take into account the physiological effects of inflammation,&#8221; says Jurga Laurencikiene, Associate Professor at the Department of Medicine, Huddinge (MedH).<\/p>\n<p>The study was conducted in collaboration with several other labs, and especially with Prof Marc Donath&#8217;s group at the University of Basel, Switzerland. The researchers used different mouse models and human experimental systems to test their hypothesis, including in vivo genetic manipulations, where the IL-1 receptor (IL1R1) was removed specifically from fat cells or from all cells in the body. This allowed them to see how the absence of this receptor affected fat storage and metabolism in the animals.<\/p>\n<p>The researchers also grew fat cell precursors from both mice and humans in the laboratory and exposed them to IL-1\u03b2. They investigated how this molecule influenced the process of these cells becoming fat cells, particularly during the early stages of their development. Gene expression analysis was used to understand which genes were activated when IL-1\u03b2 was present, and they found that key genes involved in fat formation were activated.<\/p>\n<p>The researchers also investigated how short bursts of IL-1\u03b2, such as those that occur after meals, promote healthy development of adipose tissue, while long-term exposure to high levels of IL-1\u03b2, common in obesity, disrupts this process. They observed that higher levels of potentially active IL-1\u03b2 in adipose tissue of healthy individuals are linked to smaller fat cells, suggesting a more efficient production of new fat cells and a favorable metabolism.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Significance_of_the_results_and_future_research\"><\/span>Significance of the results and future research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;Our results highlight the importance of physiological, acute inflammation for maintaining metabolic health and it is important to develop more targeted anti-inflammatory treatments that do not interfere with this tissue remodeling function,&#8221; says Kaisa Hofwimmer, Postdoctoral researcher at the Department of Medicine, Huddinge.<\/p>\n<p>The researchers plan to investigate whether IL-1\u03b2 targets specific subtypes of fat cell precursors and what makes these cell types unique. They also want to pursue mechanistic investigations to understand how chronic exposure to IL-1\u03b2 at the cellular level fails to induce new fat cell formation, despite the cells retaining their ability to respond to its inflammatory induction.<\/p>\n<p>This study opens up new insights into how inflammation can play a positive role in the body&#8217;s energy management and metabolism.<\/p>\n<div class=\"article-main__more p-4\">\n                                                                                                    <strong>More information:<\/strong><br \/>\n                                                    Kaisa Hofwimmer et al, IL-1\u03b2 promotes adipogenesis by directly targeting adipocyte precursors, <i>Nature Communications<\/i> (2024). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41467-024-51938-x\">DOI: 10.1038\/s41467-024-51938-x<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Karolinska Institutet<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/ki.se\/?l=en\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Study reveals new role for inflammatory protein in fat tissue (2024, October 21)<br \/>\n                                                 retrieved 21 October 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-10-reveals-role-inflammatory-protein-fat.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/sciencee\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2024-10-reveals-role-inflammatory-protein-fat.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microscope image of fat cells. Credit: Kaisa Hofwimmer A new study published in Nature Communications shows that the inflammatory protein IL-1\u03b2 has an important physiological function in fat tissue. Researchers at Karolinska Institutet have discovered that IL-1\u03b2 helps the body manage energy storage by signaling cells to transform into new fat cells that can safely&#8230;<\/p>\n","protected":false},"author":1,"featured_media":642095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/study-reveals-new-role.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-642094","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/642094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=642094"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/642094\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/642095"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=642094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=642094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=642094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}