{"id":643741,"date":"2024-11-08T22:03:05","date_gmt":"2024-11-08T19:03:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/mitochondrial-study-offers-new-insights-into-how-our-cells-process-rna-for-energy-production\/"},"modified":"2024-11-08T22:03:05","modified_gmt":"2024-11-08T19:03:05","slug":"mitochondrial-study-offers-new-insights-into-how-our-cells-process-rna-for-energy-production","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/mitochondrial-study-offers-new-insights-into-how-our-cells-process-rna-for-energy-production\/","title":{"rendered":"#Mitochondrial study offers new insights into how our cells process RNA for energy production"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3f6c01b4697\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3f6c01b4697\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/mitochondrial-study-offers-new-insights-into-how-our-cells-process-rna-for-energy-production\/#Unveiling_the_sequential_processing_mechanism\" >Unveiling the sequential processing mechanism<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2024\/mitochondrial-study-of.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/mitochondrial-study-of.jpg\" data-sub-html=\"Molecular reconstruction of the human mitochondrial RNase Z complex overlayed on a cryotomographic section with mitochondria from human cells. Credit: Genis Valentin Gese.\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2024\/mitochondrial-study-of.jpg\" alt=\"Mitochondrial study offers new insights into how our cells process RNA for energy production\" title=\"Molecular reconstruction of the human mitochondrial RNase Z complex overlayed on a cryotomographic section with mitochondria from human cells. Credit: Genis Valentin Gese.\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Molecular reconstruction of the human mitochondrial RNase Z complex overlayed on a cryotomographic section with mitochondria from human cells. Credit: Genis Valentin Gese.<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have made a major discovery in how human cells produce energy. Their study, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44318-024-00297-w\">published<\/a> in <i>The EMBO Journal<\/i>, reveals the detailed mechanisms of how mitochondria process transfer RNA (tRNA) molecules, which are essential for energy production.<\/p>\n<p>Mitochondria need properly processed tRNAs to make proteins for energy. Problems in tRNA processing can lead to serious mitochondrial diseases. Until now, the exact process of tRNA maturation in mitochondria was not well understood.<\/p>\n<p>&#8220;Our study reveals, at a molecular level, how the mitochondrial RNase Z complex recognizes and processes tRNA molecules,&#8221; said Gen\u00eds Valent\u00edn Ges\u00e9, the first author of the study. &#8220;By using advanced cryo-electron microscopy, we&#8217;ve been able to visualize the complex in action, capturing snapshots of tRNA at different stages of maturation. This is a significant step forward in understanding how our cells produce energy and maintain healthy function.&#8221;<\/p>\n<p>Using advanced cryo-electron microscopy, the researchers visualized the mitochondrial RNase Z complex, which is crucial for tRNA maturation. They captured high-resolution images showing how this complex processes tRNA molecules step-by-step.<\/p>\n<p>&#8220;Seeing the RNase Z complex in such detail is like watching the gears of a finely tuned engine,&#8221; explained Valent\u00edn Ges\u00e9. &#8220;We can observe how each component interacts with the tRNA, providing us with invaluable insights into the precise mechanisms of tRNA maturation.&#8221;<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2024\/new-insights-into-how-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/new-insights-into-how-2.jpg\" data-sub-html=\"Credit: &lt;i&gt;The EMBO Journal&lt;\/i&gt; (2024). DOI: 10.1038\/s44318-024-00297-w\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2024\/new-insights-into-how-2.jpg\" alt=\"New insights into how our cells process RNA for energy production\" title=\"Credit: The EMBO Journal (2024). DOI: 10.1038\/s44318-024-00297-w\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Credit: <i>The EMBO Journal<\/i> (2024). DOI: 10.1038\/s44318-024-00297-w<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"Unveiling_the_sequential_processing_mechanism\"><\/span>Unveiling the sequential processing mechanism<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>One key finding is the discovery of the 5\u2032-to-3\u2032 processing order of tRNAs, which ensures they are correctly prepared for protein synthesis. The study also explains how the RNase Z complex avoids cutting tRNAs that already have their essential 3\u2032-CCA tail, preventing errors in tRNA processing.<\/p>\n<p>&#8220;Understanding the directionality of tRNA processing is crucial,&#8221; said Martin H\u00e4llberg, senior author of the study. &#8220;It ensures that the tRNA molecules are properly matured and functional, which is essential for the mitochondria to produce energy efficiently.&#8221;<\/p>\n<p>Importantly, the research links specific mutations in the ELAC2 gene to mitochondrial diseases. Understanding these mutations helps in developing targeted therapies for conditions like cardiomyopathy and intellectual disabilities.<\/p>\n<p>&#8220;By visualizing where these mutations occur and how they affect the structure and function of the RNase Z complex, we can understand the molecular basis of certain mitochondrial diseases,&#8221; explains H\u00e4llberg. &#8220;This knowledge is crucial for developing targeted therapies to correct or compensate for these defects.&#8221;<\/p>\n<p>This breakthrough offers new pathways for diagnosing and treating mitochondrial diseases and enhances our overall understanding of mitochondrial biology.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\tGen\u00eds Valent\u00edn Ges\u00e9 et al, Structural basis of 3\u2032-tRNA maturation by the human mitochondrial RNase Z complex, <i>The EMBO Journal<\/i> (2024). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s44318-024-00297-w\">DOI: 10.1038\/s44318-024-00297-w<\/a><\/p>\n<\/p><\/div>\n<div class=\"d-inline-block text-medium mt-4\">\n<p>\n\t\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tKarolinska Institutet<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/ki.se\/?l=en\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/p>\n<\/p><\/div>\n<p>\t\t\t\t\t\t\t\t\t\t<!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n\t\t\t\t\t\t\t\t\t\t\t\t<strong>Citation<\/strong>:<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\tMitochondrial study offers new insights into how our cells process RNA for energy production (2024, November 8)<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\tretrieved 8 November 2024<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\tfrom https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2024-11-mitochondrial-insights-cells-rna-energy.html\n\t\t\t\t\t\t\t\t\t\t\t <\/p>\n<p>\n\t\t\t\t\t\t\t\t\t\t\t This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n\t\t\t\t\t\t\t\t\t\t\t part may be reproduced without the written permission. The content is provided for information purposes only.\n\t\t\t\t\t\t\t\t\t\t\t <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/sciencee\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2024-11-mitochondrial-insights-cells-rna-energy.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecular reconstruction of the human mitochondrial RNase Z complex overlayed on a cryotomographic section with mitochondria from human cells. Credit: Genis Valentin Gese. Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have made a major discovery in how human cells produce energy. Their study, published in The EMBO Journal, reveals the detailed&#8230;<\/p>\n","protected":false},"author":1,"featured_media":643742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2024\/mitochondrial-study-of.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-643741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/643741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=643741"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/643741\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/643742"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=643741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=643741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=643741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}