{"id":644079,"date":"2024-11-13T16:37:03","date_gmt":"2024-11-13T13:37:03","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/needle-free-influenza-vaccine-on-the-horizon\/"},"modified":"2024-11-13T16:37:03","modified_gmt":"2024-11-13T13:37:03","slug":"needle-free-influenza-vaccine-on-the-horizon","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/needle-free-influenza-vaccine-on-the-horizon\/","title":{"rendered":"#Needle-free influenza vaccine on the horizon"},"content":{"rendered":"
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\n Schematic diagram of the design and manufacturing process of influenza antigen-coated biopolymer particles (BPs) and induction of protective immunity against influenza in a mouse model. Credit: Advanced Healthcare Materials<\/i> (2024). DOI: 10.1002\/adhm.202304188
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Hope is on the horizon for needle-phobic patients as Griffith University researchers have created a new influenza vaccine composition designed to be administered via the nose. Griffith University Principal Research Leader, Professor Bernd Rehm said his team reprogrammed bacterial cells to create a robust vaccine designed for intranasal delivery.<\/p>\n

“The safe and synthetic particles mimic the actual virus and trigger an immune response, preventing infection,” Professor Rehm said.<\/p>\n

“By boosting the T cells along the respiratory tract, the vaccine induced protection against influenza virus variants in vivo.<\/p>\n

“These reprogrammed bacterial cell factories have the ability to abundantly produce the desired vaccine particles, which means we can produce large amounts of the vaccine in a short period of time.<\/p>\n

“The added benefit is the intranasal delivery via a drop method, thereby boosting immunity along the respiratory tract, which makes it ideal for people who are needle phobic.<\/p>\n

“A nasal drop administration can significantly limit respiratory virus replication and shedding.<\/p>\n

“More work needs to be done, but we hope to see a human intranasal influenza vaccine available to the public in the next three to four years.”<\/p>\n

The vaccine platform’s useability extends beyond human influenza, and could be used to prevent avian influenza, swine influenza, and other animal flus as the vaccine technology<\/a> is robust and cost-efficient.<\/p>\n

The entire manufacturing process leads to a vaccine with outstanding stability, making the vaccine suitable for stockpiling.<\/p>\n

Professor Bernd Rehm, from the Institute for Biomedicine and Glycomics’ Center for Cell Factories and Biopolymers, said, “The generation of new influenza vaccine which can provide long-term protection against a range of seasonal and emerging variants would be a major health and economic benefit.”<\/p>\n

The research paper “Intranasal epitope-polymer vaccine lodges resident memory T cells protecting against influenza virus” has been published<\/a> in Advanced Healthcare Materials<\/i>.<\/p>\n

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More information:<\/strong>
\n Ziyang Liu et al, Intranasal Epitope\u2010Polymer Vaccine Lodges Resident Memory T Cells Protecting Against Influenza Virus, Advanced Healthcare Materials<\/i> (2024). DOI: 10.1002\/adhm.202304188<\/a><\/p>\n<\/p><\/div>\n

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\n Citation<\/strong>:
\n Needle-free influenza vaccine on the horizon (2024, November 13)
\n retrieved 13 November 2024
\n from https:\/\/medicalxpress.com\/news<\/a>\/2024-11-needle-free-influenza-vaccine-horizon.html\n <\/p>\n

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