{"id":65009,"date":"2020-09-11T18:34:00","date_gmt":"2020-09-11T15:34:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/lab-on-paper-strip-small-inexpensive-platform-for-diagnosing-tropical-fevers\/"},"modified":"2020-09-11T18:34:00","modified_gmt":"2020-09-11T15:34:00","slug":"lab-on-paper-strip-small-inexpensive-platform-for-diagnosing-tropical-fevers","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/lab-on-paper-strip-small-inexpensive-platform-for-diagnosing-tropical-fevers\/","title":{"rendered":"#Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers"},"content":{"rendered":"

“#Lab-on-paper strip<\/a>: Small, inexpensive platform for diagnosing tropical fevers<\/strong>”<\/p>\n

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\"Lab-on-paper<\/img>
\n The Aedes aegypti mosquito can spread various tropical diseases including dengue, zika, and chikungunya, which have similar symptoms. Developing simple and low-cost diagnostic tools is crucial for early and efficient detection of these diseases. Credit: Gwangju Institute of Science<\/a> and Technology<\/a>
\n <\/figcaption><\/figure>\n<\/div>\n<\/div>\n

The ongoing COVID-19 pandemic has shown how important it is to have tools that can rapidly diagnose viral infectious diseases. Aside from the SARS-CoV-2 virus, which has currently taken the spotlight, the zika, dengue, and chikungunya viruses have also become major threats to human health in many parts of the world, particularly in tropical countries. All three viruses are transmitted by mosquitoes and cause diseases that have similar symptoms, making early diagnosis particularly difficult without complex molecular diagnostic equipment.<\/p>\n

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In a recent effort to make the diagnosis of these mosquito-borne diseases faster and easier, a team of scientists, led by Professor Min-Gon Kim from the Gwangju Institute of Science and Technology in Korea, have developed a compact, fully automatic, and inexpensive tool that can identify the presence of these viruses from a blood serum sample. The device, named LAMDA (stands for lab-on-paper for all-in-one molecular diagnostics) by the scientists, is essentially a mini laboratory on a paper strip\u2014vaguely reminiscent of over-the-counter pregnancy tests.<\/p>\n

LAMDA performs all the steps of a standard nucleic acid test (a molecular diagnostic test), namely sampling, extraction, amplification, and detection of the target viral RNA, without external intervention at any intermedia<\/a>te step. To use LAMDA, one has to simply place a drop of blood serum and some drops of distilled water on two pads. The liquids naturally flow through the paper strip horizontally and reach the base of a small vertical stack of layers that extracts all the RNA from the sample and multiplies any existing viral RNA of the three diseases.
\nThe top layer of the vertical stack comprises individual “reaction” patches, each designed to detect one of the three diseases. After the RNA is extracted, it flows up to the top layer, where LAMP (loop-mediated isothermal amplification) reactions cause the fluorescent indicators on a patch to become dim if its target viral RNA is present in the sample.
\nIn this way, LAMDA can correctly diagnose any of the three mosquito-borne diseases in less than an hour. Excited about the results, which are published in Elsevier’s Biosensors and Bioelectronics<\/i>, Prof Kim remarks, “We believe that with minor modifications, such as a portable system to maintain reaction temperature at 65\u00b0C and a means to detect the fluorescence change with a smartphone, the proposed all-in-one paper chip can become a portable, low-cost, user-friendly, sensitive, and specific nucleic acid test platform with great potential in point-of-care diagnostics.”
\nLAMDA could be an excellent option for resource-limited clinics and hospitals, which are unfortunately common among countries most affected by mosquito-borne diseases. It could also bolster future research in the field of diagnostics for other infectious diseases. “We certainly hope that our app<\/a>roach and achievements with LAMDA will be helpful to advance research and development of on-site medical diagnostic tools,” Prof Kim concludes.
\nPerhaps a generation of accurate and high-utility pocket diagnostic tools is on the horizon!<\/p>\n

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More information:<\/strong>
\n Youngung Seok et al, Lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum, Biosensors and Bioelectronics<\/i> (2020). DOI: 10.1016\/j.bios.2020.112400\n <\/div>\n

Provided by
\n GIST (Gwangju Institute of Science and Technology)<\/p>\n

\n Citation<\/strong>:
\n Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers (2020, September 11)
\n retrieved 11 September 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-09-lab-on-paper-small-inexpensive-platform-tropical.html<\/p>\n

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“#Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers” The Aedes aegypti mosquito can spread various tropical diseases including dengue, zika, and chikungunya, which have similar symptoms. Developing simple and low-cost diagnostic tools is crucial for early and efficient detection of these diseases. Credit: Gwangju Institute of Science and Technology The ongoing COVID-19 pandemic has…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[16991,68002,68001],"class_list":["post-65009","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-analytical-chemistry","tag-inexpensive-platform-for-diagnosing-tropical-fevers","tag-lab-on-paper-strip-small"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/65009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=65009"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/65009\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=65009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=65009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=65009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}