{"id":653543,"date":"2025-02-14T12:15:17","date_gmt":"2025-02-14T09:15:17","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/mouse-study-finds-impaired-cell-development\/"},"modified":"2025-02-14T12:15:17","modified_gmt":"2025-02-14T09:15:17","slug":"mouse-study-finds-impaired-cell-development","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/mouse-study-finds-impaired-cell-development\/","title":{"rendered":"#Mouse study finds impaired cell development"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a33e47fda5b8\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a33e47fda5b8\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/mouse-study-finds-impaired-cell-development\/#Fasting_improves_metabolism_in_older_mice_but_not_in_the_young\" >Fasting improves metabolism in older mice, but not in the young<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/mouse-study-finds-impaired-cell-development\/#Defective_beta_cells_resemble_those_of_type_1_diabetes_patients\" >Defective beta cells resemble those of type 1 diabetes patients<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/mouse-study-finds-impa.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2025\/mouse-study-finds-impa.jpg\" data-sub-html=\"The researchers investigated the impact of intermittent fasting on the beta cells. In the pancreas of mature mice, no negative effects on the beta cells were observed (here stained green). Credit: Leonardo Matta \/ TUM\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2025\/mouse-study-finds-impa.jpg\" alt=\"Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers\" title=\"The researchers investigated the impact of intermittent fasting on the beta cells. In the pancreas of mature mice, no negative effects on the beta cells were observed (here stained green). Credit: Leonardo Matta \/ TUM\" width=\"800\" height=\"439\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                The researchers investigated the impact of intermittent fasting on the beta cells. In the pancreas of mature mice, no negative effects on the beta cells were observed (here stained green). Credit: Leonardo Matta \/ TUM<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers from Technical University of Munich (TUM), LMU Hospital Munich, and Helmholtz Munich discovered that chronic intermittent fasting disrupted the development of insulin-producing beta cells in young mice. The findings raise concerns about potential risks for humans, especially teenagers.<\/p>\n<p>The research is <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724015766\" target=\"_blank\">published<\/a> in the journal <i>Cell Reports<\/i>.<\/p>\n<p>&#8220;Intermittent fasting is known to have benefits, including boosting metabolism and helping with weight loss and heart disease. But until now, its potential side effects weren&#8217;t well understood,&#8221; says Alexander Bartelt, the Else Kr\u00f6ner Fresenius Professor and Chair of Translational Nutritional Medicine at TUM.<\/p>\n<p>In the study, the team shows that intermittent fasting during adolescence could have long-term negative effects on metabolism.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Fasting_improves_metabolism_in_older_mice_but_not_in_the_young\"><\/span>Fasting improves metabolism in older mice, but not in the young<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The researchers studied three groups of mice: adolescent, adult, and older animals. The mice remained without food for one day and were fed normally for two days. After 10 weeks, insulin sensitivity improved in both the adult and older mice, meaning that their metabolism responded better to insulin produced by the pancreas. This is key to regulating blood sugar levels and preventing conditions like type 2 diabetes.<\/p>\n<p>However, the adolescent mice showed a troubling decline in their beta cell function, the insulin-producing cells of the pancreas. Insufficient insulin production is linked to diabetes and disrupted metabolism.<\/p>\n<p>&#8220;Intermittent fasting is usually thought to benefit beta cells, so we were surprised to find that young mice produced less insulin after the extended fasting,&#8221; explains Leonardo Matta from Helmholtz Munich, one of the study&#8217;s lead authors.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/mouse-study-finds-impa-1.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/mouse-study-finds-impa-1.jpg\" data-sub-html=\"Langerhans islets after chronic intermittent fasting. On the left those of an adult animal, on the right those of a young animal. The beta cells of the pancreatic Langerhans' islets produce insulin. The Langerhans' islets of the young animal exhibit fewer fully matured beta cells, which are stained green in this image. Credit: Leonardo Matta \/ TUM\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2025\/mouse-study-finds-impa-1.jpg\" alt=\"Mouse study finds impaired cell development: Intermittent fasting could be unsafe for teenagers\" title=\"Langerhans islets after chronic intermittent fasting. On the left those of an adult animal, on the right those of a young animal. The beta cells of the pancreatic Langerhans' islets produce insulin. The Langerhans' islets of the young animal exhibit fewer fully matured beta cells, which are stained green in this image. Credit: Leonardo Matta \/ TUM\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Langerhans islets after chronic intermittent fasting. On the left those of an adult animal, on the right those of a young animal. The beta cells of the pancreatic Langerhans&#8217; islets produce insulin. The Langerhans&#8217; islets of the young animal exhibit fewer fully matured beta cells, which are stained green in this image. Credit: Leonardo Matta \/ TUM<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"Defective_beta_cells_resemble_those_of_type_1_diabetes_patients\"><\/span>Defective beta cells resemble those of type 1 diabetes patients<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The researchers used the latest single-cell sequencing to uncover the cause of the beta cell impairment. By examining the blueprint of the pancreas, the team found that the beta cells in the younger mice failed to mature properly.<\/p>\n<p>&#8220;At some point, the cells in the adolescent mice stopped developing and produced less insulin,&#8221; says Peter Weber from Helmholtz Munich, also a lead author. Older mice, whose beta cells were already mature before the fasting began, remained unaffected.<\/p>\n<p>The team compared their mouse findings to data from human tissues. They found that patients with type 1 diabetes, where beta cells are destroyed by an autoimmune response, showed similar signs of impaired cell maturation. This suggests that the findings from the mouse study could also be relevant to humans.<\/p>\n<p>&#8220;Our study confirms that intermittent fasting is beneficial for adults, but it might come with risks for children and teenagers,&#8221; says Stephan Herzig, a professor at TUM and director of the Institute for Diabetes and Cancer at Helmholtz Munich.<\/p>\n<p>&#8220;The next step is digging deeper into the molecular mechanisms underlying these observations. If we better understand how to promote healthy beta cell development, it will open new avenues for treating diabetes by restoring insulin production.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Leonardo Matta et al, Chronic intermittent fasting impairs \u03b2 cell maturation and function in adolescent mice, <i>Cell Reports<\/i> (2025). <a rel=\"nofollow\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.celrep.2024.115225\" target=\"_blank\">DOI: 10.1016\/j.celrep.2024.115225<\/a><\/p>\n<\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tTechnical University Munich<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.tum.de\/\" target=\"_blank\" rel=\"nofollow\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Intermittent fasting could be unsafe for teenagers: Mouse study finds impaired cell development (2025, February 14)<br \/>\n                                                 retrieved 14 February 2025<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2025-02-intermittent-fasting-unsafe-teenagers-mouse.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. 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Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/category\/sciencee\/\" target=\"_blank\" >Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2025-02-intermittent-fasting-unsafe-teenagers-mouse.html\" target=\"_blank\" >Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The researchers investigated the impact of intermittent fasting on the beta cells. In the pancreas of mature mice, no negative effects on the beta cells were observed (here stained green). Credit: Leonardo Matta \/ TUM A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers from Technical University&#8230;<\/p>\n","protected":false},"author":1,"featured_media":653544,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2025\/mouse-study-finds-impa.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-653543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/653543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=653543"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/653543\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/653544"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=653543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=653543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=653543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}