{"id":669999,"date":"2025-05-18T22:50:44","date_gmt":"2025-05-18T19:50:44","guid":{"rendered":""},"modified":"2025-05-18T22:50:44","modified_gmt":"2025-05-18T19:50:44","slug":"noninvasive-prenatal-testing-identifies-twice-as-many-down-syndrome-cases-as-second-trimester-serum-screening","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/noninvasive-prenatal-testing-identifies-twice-as-many-down-syndrome-cases-as-second-trimester-serum-screening\/","title":{"rendered":"Noninvasive prenatal testing identifies twice as many Down syndrome cases as second-trimester serum screening"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a273920350f1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a273920350f1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/noninvasive-prenatal-testing-identifies-twice-as-many-down-syndrome-cases-as-second-trimester-serum-screening\/#NIPT_as_first-tier_screening_method_for_DS\" >NIPT as first-tier screening method for DS<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/study-nipt-identifies.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/study-nipt-identifies.jpg\" data-sub-html=\"Credit: BGI Genomics\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2025\/study-nipt-identifies.jpg\" alt=\"Study: NIPT identifies twice as many down syndrome cases as STSS\" title=\"Credit: BGI Genomics\" width=\"800\" height=\"450\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: BGI Genomics<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A novel study has analyzed the cost-effectiveness of different Down syndrome (DS) screening strategies. The result confirms that noninvasive prenatal testing (NIPT) outperforms second-trimester serum screening (STSS) in accuracy and cost-effectiveness, as NIPT identifies twice as many DS cases as STSS.<\/p>\n<p>The study was conducted by researchers from Changsha Hospital for Maternal &amp; Child Health Care, School of Public Administration, Hunan University in China, and BGI Genomics. The paper was <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1535381\/full\" target=\"_blank\">published<\/a> in the journal <i>Frontiers in Public Health<\/i> early this month.<\/p>\n<p>Conducted on a large scale, involving 140,472 pregnant women from March 2018 to December 2020, this real-world analysis evaluates the performance of NIPT compared to traditional STSS. The researchers aimed to assess which screening strategy would offer the best balance between effectiveness and cost, ensuring that prenatal care can be both advanced and accessible.<\/p>\n<p>Key to the study was its examination of the sensitivity, specificity, and positive predictive value of NIPT in detecting trisomy 21\u2014one of the key indicators of DS. NIPT showed significantly higher sensitivity and specificity compared to STSS, and NIPT identifies twice as many DS cases as STSS, making it a far more reliable option.<\/p>\n<p>The universal NIPT screening strategy, which involves offering NIPT to all pregnant women, was found to be the most effective in detecting DS cases, with a net benefit far exceeding that of STSS. Not only did NIPT detect more cases, but it did so at a lower incremental cost, establishing it as a strong contender for widespread implementation.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"NIPT_as_first-tier_screening_method_for_DS\"><\/span>NIPT as first-tier screening method for DS<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In this study, NIPT exhibited significantly higher sensitivity, specificity, and positive predictive value compared to STSS for DS. NIPT also demonstrated lower false positive and false negative rates. Across all age groups of pregnant women, NIPT consistently maintained excellent sensitivity and specificity, outperforming STSS in all detection metrics.<\/p>\n<p>NIPT effectively reduced the need for invasive prenatal diagnostic procedures, thereby optimizing resource utilization and minimizing the risks associated with invasive techniques. Given its superior detection performance, researchers suggested that NIPT should be considered as a first-tier screening method for Down syndrome.<\/p>\n<p>The analysis found that universal NIPT screening led to the detection of 163 DS cases with a cost-effectiveness ratio of RMB 1:9.53. In comparison, a combined STSS and NIPT strategy detected fewer cases, albeit at a higher cost. The universal <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach offers an accessible yet highly effective solution for prenatal screening.<\/p>\n<p>This study proves that NIPT has superior testing performance compared to STSS, signaling a significant step toward better prenatal care. It provides clear evidence that NIPT not only enhances the accuracy of Down syndrome screening but also offers substantial cost savings, making it a feasible option for widespread adoption.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Jing Liu et al, Cost-effectiveness of different screening strategies for Down syndrome: a real-world analysis in 140,472 women, <i>Frontiers in Public Health<\/i> (2025). <a rel=\"nofollow\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.3389\/fpubh.2025.1535381\" target=\"_blank\">DOI: 10.3389\/fpubh.2025.1535381<\/a><\/p>\n<\/p><\/div>\n<p>\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tBGI Genomics<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Noninvasive prenatal testing identifies twice as many Down syndrome cases as second-trimester serum screening (2025, May 18)<br \/>\n                                                 retrieved 18 May 2025<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2025-05-noninvasive-prenatal-syndrome-cases-trimester.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/category\/sciencee\/\" target=\"_blank\" >Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2025-05-noninvasive-prenatal-syndrome-cases-trimester.html\" target=\"_blank\" >Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: BGI Genomics A novel study has analyzed the cost-effectiveness of different Down syndrome (DS) screening strategies. The result confirms that noninvasive prenatal testing (NIPT) outperforms second-trimester serum screening (STSS) in accuracy and cost-effectiveness, as NIPT identifies twice as many DS cases as STSS. The study was conducted by researchers from Changsha Hospital for Maternal&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-669999","post","type-post","status-publish","format-standard","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/669999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=669999"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/669999\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=669999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=669999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=669999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}