{"id":674142,"date":"2025-06-10T03:12:56","date_gmt":"2025-06-10T00:12:56","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/smartphone-tests-could-accelerate-drug-development-for-huntingtons-disease\/"},"modified":"2025-06-10T03:12:56","modified_gmt":"2025-06-10T00:12:56","slug":"smartphone-tests-could-accelerate-drug-development-for-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/smartphone-tests-could-accelerate-drug-development-for-huntingtons-disease\/","title":{"rendered":"Smartphone tests could accelerate drug development for Huntington&#8217;s disease"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a28b7a4012e2\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a28b7a4012e2\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/smartphone-tests-could-accelerate-drug-development-for-huntingtons-disease\/#Developing_HDDMS_and_the_smartphone_tests\" >Developing HDDMS and the smartphone tests<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/smartphone-tests-could-accelerate-drug-development-for-huntingtons-disease\/#Study_limitations\" >Study limitations<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/smartphone-tests-could.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2025\/smartphone-tests-could.jpg\" data-sub-html=\"Yearly change (95% CI) on the HDDMS, cUHDRS, and cUHDRS components by CAG category. Credit: &lt;i&gt;Brain&lt;\/i&gt; (2025). DOI: 10.1093\/brain\/awaf127\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2025\/smartphone-tests-could.jpg\" alt=\"Smartphone tests could accelerate drug development for Huntington's disease\" title=\"Yearly change (95% CI) on the HDDMS, cUHDRS, and cUHDRS components by CAG category. Credit: Brain (2025). DOI: 10.1093\/brain\/awaf127\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Yearly change (95% CI) on the HDDMS, cUHDRS, and cUHDRS components by CAG category. Credit: <i>Brain<\/i> (2025). DOI: 10.1093\/brain\/awaf127<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/watch-movies-tv-seriess\/\" data-internallinksmanager029f6b8e52c=\"8\" title=\"Watch Movies &amp; TV Series\" target=\"_blank\" rel=\"noopener\">series<\/a> of digital tests carried out via a smartphone <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a> could enhance the detection of disease progression in Huntington&#8217;s disease and improve the efficiency of clinical trials, finds research led by scientists at University College London (UCL) and Roche.<\/p>\n<p>The research, <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awaf127\/8111582\" target=\"_blank\">published<\/a> in <i>Brain<\/i>, highlights how digitizing tests designed to measure the progression of motor symptoms in people with Huntington&#8217;s disease can provide a sensitive and reliable way to track changes in the function of patients.<\/p>\n<p>Once participants have completed five simple tests of movement control, including assessment of balance, finger tapping and involuntary movements, a Huntington&#8217;s Disease Digital Motor Score (HDDMS) is calculated. A lower HDDMS value indicates better motor function, while a higher HDDMS value indicates worse motor function.<\/p>\n<p>By regularly performing the tests in their everyday lives, participants&#8217; disease progression can be monitored by doctors and researchers using the HDDMS. The researchers hope that the HDDMS will help in clinical trials by allowing researchers to detect even small changes in symptoms\u2014making it easier to evaluate the potential of new treatments.<\/p>\n<p>It would also help researchers to detect disease changes with fewer participants, shortening study durations and potentially accelerating the development of new Huntington&#8217;s disease therapies.<\/p>\n<p>Professor Ed Wild (UCL Huntington&#8217;s Disease Centre) said, &#8220;Our findings suggest that incorporating the HDDMS in clinical trials will help to give clearer answers about whether a potential treatment is working, with fewer participants or shorter lead times than conventional measures.<\/p>\n<p>&#8220;What&#8217;s more, the fact that the HDDMS is evaluated in a five-minute assessment in people&#8217;s homes makes it convenient and potentially more meaningful than in-clinic measures of motor impairment.&#8221;<\/p>\n<p>Huntington&#8217;s disease is a devastating, inherited neurodegenerative condition causing progressive loss of movement control, thinking and behavior. There is currently no cure and existing treatments mainly focus on managing symptoms rather than slowing or stopping the disease itself. Promising new therapies are undergoing clinical trials\u2014making the efficiency and accuracy of the HDDMS more important than ever.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Developing_HDDMS_and_the_smartphone_tests\"><\/span>Developing HDDMS and the smartphone tests<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The HDDMS was developed by researchers at UCL and Roche using data collected from 1,048 people across four observational and interventional studies. From a large battery of novel digital tasks presented via a custom smartphone app, the researchers were able to distill the measurements that best predicted disease progression, resulting in the HDDMS battery.<\/p>\n<p>By using the selected tests, the researchers found that the HDDMS was around twice as sensitive in detecting real changes in motor function as the currently most used clinical measure, the composite Unified Huntington&#8217;s Disease Rating Scale.<\/p>\n<p>Professor Wild added, &#8220;More sensitive tools to measure disease progression are particularly valuable in rare diseases like Huntington&#8217;s disease. The fewer people there are who can possibly participate in clinical trials, the more important it becomes to minimize trial burden and size. Sensitive measurement tools like the HDDMS may therefore facilitate Huntington&#8217;s disease research across the scientific community.&#8221;<\/p>\n<p>The new research underscores the growing role of digital biomarkers in neurological research and highlights the potential for <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a>-driven innovations in disease monitoring and drug development.<\/p>\n<p>The HDDMS is available to academic and industry parties working on Huntington&#8217;s disease via Roche Diagnostics.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Study_limitations\"><\/span>Study limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The research has some limitations, including that all data has been collected from people participating in specific clinical trials. Therefore, HDDMS has not been evaluated in people before symptoms onset, nor in people with advanced HD.<\/p>\n<p>Additionally, while the HDDMS is sensitive to changes, more research is needed to confirm its ability to predict long-term functional decline.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Louis-Solal Giboin et al, A digital motor score for sensitive detection of progression in Huntington&#8217;s disease, <i>Brain<\/i> (2025). <a rel=\"nofollow\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1093\/brain\/awaf127\" target=\"_blank\">DOI: 10.1093\/brain\/awaf127<\/a><\/p>\n<div class=\"mt-3\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<strong>Journal information:<\/strong><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<cite>Brain<\/cite><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/brain.oxfordjournals.org\/\" target=\"_blank\" rel=\"nofollow\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tUniversity College London<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.ucl.ac.uk\/\" target=\"_blank\" rel=\"nofollow\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Smartphone tests could accelerate drug development for Huntington&#8217;s disease (2025, June 9)<br \/>\n                                                 retrieved 9 June 2025<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2025-06-smartphone-drug-huntington-disease.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/category\/sciencee\/\" target=\"_blank\" >Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2025-06-smartphone-drug-huntington-disease.html\" target=\"_blank\" >Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yearly change (95% CI) on the HDDMS, cUHDRS, and cUHDRS components by CAG category. Credit: Brain (2025). DOI: 10.1093\/brain\/awaf127 A series of digital tests carried out via a smartphone app could enhance the detection of disease progression in Huntington&#8217;s disease and improve the efficiency of clinical trials, finds research led by scientists at University College&#8230;<\/p>\n","protected":false},"author":1,"featured_media":674143,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2025\/smartphone-tests-could.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-674142","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/674142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=674142"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/674142\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/674143"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=674142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=674142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=674142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}