{"id":677822,"date":"2025-06-29T12:35:43","date_gmt":"2025-06-29T09:35:43","guid":{"rendered":"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/"},"modified":"2025-06-29T12:35:43","modified_gmt":"2025-06-29T09:35:43","slug":"people-with-severe-diabetes-cured-in-small-stem-cell-trial","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/","title":{"rendered":"People with severe diabetes cured in small stem cell trial"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a35f88b1f384\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a35f88b1f384\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/#What_are_stem_cell_therapies\" >What are stem cell therapies?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/#How_does_the_treatment_work\" >How does the treatment work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/#What_are_the_side_effects\" >What are the side effects?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/#Is_it_better_than_other_treatments\" >Is it better than other treatments?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/buradabiliyorum.com\/en\/people-with-severe-diabetes-cured-in-small-stem-cell-trial\/#When_might_this_be_more_widely_available\" >When might this be more widely available?<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/diabetes-1.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/diabetes-1.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/diabetes-1.jpg\" alt=\"diabetes\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>The cure for diabetes is a life free from daily insulin injections. Based on that criterion, ten out of 12 people (83%) in a <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2506549\" target=\"_blank\">new clinical trial<\/a> were cured of their diabetes one year after receiving an advanced stem cell therapy.<\/p>\n<p>This study used laboratory-grown pancreatic islet cells. They were infused into the liver, where they took up residence. Within a year, most participants no longer required insulin injections.<\/p>\n<p>One of the most striking benefits was the rapid prevention of dangerously low blood sugar levels, called hypoglycemia. Before transplantation, all participants had at least two episodes of severe hypoglycemia within the previous year.<\/p>\n<p>After transplantation, these episodes dis<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>eared for all participants.<\/p>\n<p>These are impressive results, but what are stem cell therapies? How does the treatment work? How do they compare to other treatments? And what are the possible side effects?<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_stem_cell_therapies\"><\/span>What are stem cell therapies?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Stem cells are cells that can be turned into almost any other cell type. The major benefit is that scientists in the lab can create the correct cells, the ones needed to treat a disease, and in the desired amount.<\/p>\n<p>In the case of type 1 diabetes, the required cells are pancreatic islets. Most of the cells in these islets make insulin.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_does_the_treatment_work\"><\/span>How does the treatment work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The laboratory-grown cells are infused into the body. A common place is in a liver vein, where the cells attach. The advantage here is that insulin delivered towards the liver works much better than, say, just under the skin.<\/p>\n<p>This is because switching off excessive liver glucose production is the primary action of insulin to correct blood sugar levels.<\/p>\n<p>In the current study, the function of the transplanted cells, a treatment called XV-880, improved within the first three months. Blood glucose levels were better controlled. No severe hypoglycemia was found and a marker of insulin production improved.<\/p>\n<p>Throughout the first year, participants were able to reduce the amount of insulin they took, until most were free from insulin injections.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_the_side_effects\"><\/span>What are the side effects?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The biggest downside of this new treatment is that all participants will need to take immunosuppressant drugs for the rest of their lives. This will reduce the immune system&#8217;s ability to recognize the transplanted cells and remove them.<\/p>\n<p>This increases the risk of infections and certain types of cancer. That&#8217;s because the immune system plays an important role in removing potentially cancerous cells.<\/p>\n<p>In this new study, two participants died. On closer inspection, these were unrelated to the treatment itself. Most participants had upset tummies, with diarrhea as the most common side effect, in 11 of 14 people. More than half also had headaches and nausea.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Is_it_better_than_other_treatments\"><\/span>Is it better than other treatments?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>For many years, people struggling with severe hypoglycemia have been able to receive new pancreatic islets from deceased donors. For a minority, this also leads to freedom from insulin injections over the longer term.<\/p>\n<p>Typically, two or three donor pancreases need to be pooled together to give to one recipient. People may also need a second infusion within a relatively short time frame. Islet transplants are typically limited by the amount of donor cells available, which is not enough.<\/p>\n<p>This new approach gives a standardized dose of cells, of known quality. The timing of the procedure is also not tied to the deaths of donors.<\/p>\n<p>This new study is also not the first. <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867424010225?via%3Dihub\" target=\"_blank\">In 2024<\/a>, a 25-year-old woman with type 1 diabetes received a stem cell-derived islet transplant, which also led to freedom from insulin injections.<\/p>\n<p><a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41421-024-00662-3\" target=\"_blank\">A 59-year-old man<\/a> with poorly controlled type 2 diabetes was also cured with another type of stem cell transplant.<\/p>\n<p>Both of these treatments will require lifelong immunosuppression. This is undesirable for many people and may limit uptake.<\/p>\n<p>This is driving efforts to create treatment versions that do not require immunosuppression. There are efforts to enclose the transplanted cells inside devices that let insulin out but prevent the immune cells from getting in. There are also genetic editing techniques being used to cloak cells from the immune system.<\/p>\n<p>However, these approaches are further behind in clinical development.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"When_might_this_be_more_widely_available\"><\/span>When might this be more widely available?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>This is difficult to estimate. Larger trials with XV-880 are planned. The same company planned to test an immunosuppression-free version of their cell therapy, called XV-264. However, this failed to work well enough in a small pilot study and will no longer progress through trials.<\/p>\n<p>There is also the issue of cost. It is not yet clear how much a treatment like this will cost. This will affect who can access advanced cell therapies. We also don&#8217;t yet know if and when the transplanted cells may start to fail.<\/p>\n<p>In this trial, the company is monitoring recipients for ten years in total. An initial five-year follow-up then a five-year extension study.<\/p>\n<p>This gives an idea of how long we might need to wait. Despite this, the recent developments give reason for cautious optimism. It may be possible in the not-so-distant future to have a life without daily insulin injections.<\/p>\n<div class=\"d-inline-block text-medium my-4\">\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tThe Conversation<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/theconversation.com\" target=\"_blank\" rel=\"nofollow\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a><\/p><\/div>\n<p class=\"article-main__note mt-4\">\n                                                This article is republished from <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/theconversation.com\" target=\"_blank\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/theconversation.com\/people-with-severe-diabetes-cured-in-small-stem-cell-trial-259569\" target=\"_blank\">original article<\/a>.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/259569\/count.gif?distributor=republish-lightbox-advanced\" alt=\"The Conversation\" width=\"1\" height=\"1\"\/>\n                                            <\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 People with severe diabetes cured in small stem cell trial (2025, June 28)<br \/>\n                                                 retrieved 29 June 2025<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2025-06-people-severe-diabetes-small-stem.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" target=\"_blank\" >Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2025-06-people-severe-diabetes-small-stem.html\" target=\"_blank\" >Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Pixabay\/CC0 Public Domain The cure for diabetes is a life free from daily insulin injections. Based on that criterion, ten out of 12 people (83%) in a new clinical trial were cured of their diabetes one year after receiving an advanced stem cell therapy. This study used laboratory-grown pancreatic islet cells. They were infused&#8230;<\/p>\n","protected":false},"author":1,"featured_media":677823,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/diabetes-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-677822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/677822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=677822"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/677822\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/677823"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=677822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=677822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=677822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}