{"id":697033,"date":"2025-10-28T11:25:13","date_gmt":"2025-10-28T08:25:13","guid":{"rendered":"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/"},"modified":"2025-10-28T11:25:13","modified_gmt":"2025-10-28T08:25:13","slug":"exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/","title":{"rendered":"Exercise-induced vesicles help protect pancreatic cells and guard against diabetes"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3fd1c98ddac\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3fd1c98ddac\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/#Whats_the_main_focus_of_your_thesis\" >What&#8217;s the main focus of your thesis?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/#Which_are_the_most_important_results\" >Which are the most important results?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/#How_can_this_new_knowledge_contribute_to_the_improvement_of_peoples_health\" >How can this new knowledge contribute to the improvement of people&#8217;s health?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/buradabiliyorum.com\/en\/exercise-induced-vesicles-help-protect-pancreatic-cells-and-guard-against-diabetes\/#What_are_your_future_ambitions\" >What are your future ambitions?<\/a><\/li><\/ul><\/nav><\/div>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/-extracellular-vesicle.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/-extracellular-vesicle.jpg\" data-sub-html=\"Credit: Unsplash\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2025\/-extracellular-vesicle.jpg\" alt=\"extracellular vesicles\" title=\"Credit: Unsplash\/CC0 Public Domain\" width=\"800\" height=\"451\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Unsplash\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Exercise is known for the positive effects on metabolic diseases, partly because of the release of circulating extracellular vesicles (EVs) that <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>te intercellular communication and organ crosstalk.<\/p>\n<p>In a new <a rel=\"nofollow\" target=\"_blank\" href=\"https:\/\/openarchive.ki.se\/articles\/thesis\/Exercise-induced_extracellular_vesicles_and_their_protective_role_against_diabetes\/30022921\/1\" target=\"_blank\">doctoral thesis<\/a> from Karolinska Institutet, Zhenghao Wang, doctoral student at the Department of Molecular Medicine and Surgery, explores the molecular composition and biofunction of exercise-induced EVs, focusing on their role in health benefits and pancreatic \u03b2-cell protection.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Whats_the_main_focus_of_your_thesis\"><\/span>What&#8217;s the main focus of your thesis?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;The aim of my thesis is to investigate the potential positive regulatory roles of exercise-induced circulating extracellular vesicles in pancreatic \u03b2-cell function and survival, and explore its underlying molecular mechanisms,&#8221; says Wang, doctoral student at the Signal Transduction research group, Department of Molecular Medicine and Surgery, Karolinska Institutet.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Which_are_the_most_important_results\"><\/span>Which are the most important results?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;This study reveals that exercise systemically improves diabetes by triggering a multi-organ exosomal network, moving beyond traditional single-organ perspectives and providing novel systemic insights. We identify exercise-induced exosomal miR-124 as a key regulator of endoplasmic reticulum stress (ERS), bridging exercise to cytoprotection in diabetes and offering a novel therapeutic candidate.&#8221;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_can_this_new_knowledge_contribute_to_the_improvement_of_peoples_health\"><\/span>How can this new knowledge contribute to the improvement of people&#8217;s health?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;By identifying exosomal miR-124 as a key mediator, we can develop targeted exercise regimens optimized for diabetes prevention and treatment, particularly for high-risk individuals. Blood tests measuring miR-124 levels could help track therapeutic responses. Engineered exosomes or synthetic miR-124 mimics could be developed as injectable &#8216;exercise mimetics,&#8217; offering benefits for diabetic patients who cannot engage in physical activity due to mobility limitations or other health complications.&#8221;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_your_future_ambitions\"><\/span>What are your future ambitions?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8220;Our goal is to transform exercise biology into tangible solutions, moving from mechanistic insights to diagnostics, therapeutics, and equitable health innovations that combat diabetes and beyond,&#8221; says Wang.<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Zhenghao Wang, Exercise-induced extracellular vesicles and their protective role against diabetes (2025). <a rel=\"nofollow\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.69622\/30022921.v1\" target=\"_blank\">DOI: 10.69622\/30022921.v1<\/a><\/p>\n<\/div>\n<div class=\"d-inline-block text-medium my-4\">\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tKarolinska Institutet<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a rel=\"nofollow\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/ki.se\/?l=en\" target=\"_blank\" rel=\"nofollow\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Exercise-induced vesicles help protect pancreatic cells and guard against diabetes (2025, October 28)<br \/>\n                                                 retrieved 28 October 2025<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2025-10-vesicles-pancreatic-cells-diabetes.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMN63nwsw68G3Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" target=\"_blank\" >Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2025-10-vesicles-pancreatic-cells-diabetes.html\" target=\"_blank\" >Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Unsplash\/CC0 Public Domain Exercise is known for the positive effects on metabolic diseases, partly because of the release of circulating extracellular vesicles (EVs) that mediate intercellular communication and organ crosstalk. In a new doctoral thesis from Karolinska Institutet, Zhenghao Wang, doctoral student at the Department of Molecular Medicine and Surgery, explores the molecular composition&#8230;<\/p>\n","protected":false},"author":1,"featured_media":697034,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2025\/-extracellular-vesicle.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-697033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/697033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=697033"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/697033\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/697034"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=697033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=697033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=697033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}