{"id":72739,"date":"2020-09-22T18:12:06","date_gmt":"2020-09-22T15:12:06","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/the-impact-of-human-mobility-on-disease-spread\/"},"modified":"2020-09-22T18:12:06","modified_gmt":"2020-09-22T15:12:06","slug":"the-impact-of-human-mobility-on-disease-spread","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/the-impact-of-human-mobility-on-disease-spread\/","title":{"rendered":"#The impact of human mobility on disease spread"},"content":{"rendered":"

“#The impact of human mobility on disease spread<\/strong>”<\/p>\n

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Due to continual improvements in transportation technology<\/a>, people travel<\/a> more extensively than ever before. Although this strengthened connection between faraway countries comes with many benefits, it also poses a serious threat to disease control and prevention. When infected humans travel to regions that are free of their particular contagions, they might inadvertently transmit their infections to local residents and cause disease outbreaks. This process has occurred repeatedly throughout history; some recent examples include the SARS outbreak in 2003, the H1N1 influenza pandemic in 2009, and\u2014most notably\u2014the ongoing COVID-19 pandemic.<\/p>\n


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Imported cases challenge the ability of nonendemic countries\u2014countries where the disease in question does not occur regularly\u2014to entirely eliminate the contagion. When combined with additional factors such as genetic mutation in pathogens, this issue makes the global eradication of many diseases exceedingly difficult, if not impossible. Therefore, reducing the number of infections is general<\/a>ly a more feasible goal. But to achieve control of a disease, health agencies must understand how travel between separate regions impacts its spread.<\/p>\n

In a paper publishing on Tuesday in the SIAM Journal of App<\/a>lied Mathematics<\/i>, Daozhou Gao of Shanghai Normal University investigated the way in which human dispersal affects disease control and total extent of an infection’s spread. Few previous studies have explored the impact of human movement on infection size or disease prevalence\u2014defined as the proportion of individuals in a population that are infected with a specific pathogen\u2014in different regions. This area of research is especially pertinent during severe disease outbreaks, when governing leaders may dramatically reduce human mobility by closing borders and restricting travel. During these times, it is essential to understand how limiting people’s movements affects the spread of disease.<\/p>\n

To examine the spread of disease throughout a population, researchers often use mathematical models that sort individuals into multiple distinct groups, or “compartments.” In his study, Gao utilized a particular type of compartmental model called the susceptible-infected-susceptible (SIS) patch model. He divided the population in each patch\u2014a group of people such as a community, city, or country\u2014into two compartments: infected people who currently have the designated illness, and people who are susceptible to catching it. Human migration then connects the patches. Gao assumed that the susceptible and infected subpopulations spread out at the same rate, which is generally true for diseases like the common cold that often only mildly affect mobility.<\/p>\n

Each patch in Gao’s SIS model has a certain infection risk that is represented by its basic reproduction number (R0<\/sub>)\u2014the quantity that predicts how many cases will be caused by the presence of a single contagious person within a susceptible population. “The larger the reproduction number, the higher the infection risk,” Gao said. “So the patch reproduction number of a higher-risk patch is assumed to be higher than that of a lower-risk patch.” However, this number only measures the initial transmission potential; it can rarely predict the true extent of infection.<\/p>\n

Gao first used his model to investigate the effect of human movement on disease control by comparing the total infection sizes that resulted when individuals dispersed quickly versus slowly. He found that if all patches recover at the same rate, large dispersal results in more infections than small dispersal. Surprisingly, an increase in the amount by which people spread can actually reduce R0<\/sub> while still increasing the total amount of infections.<\/p>\n

The SIS patch model can also help elucidate how dispersal impacts the distribution of infections and prevalence of the disease within each patch. Without diffusion between patches, a higher-risk patch will always have a higher prevalence of disease, but Gao wondered if the same was true when people can travel to and from that high-risk patch. The model revealed that diffusion can decrease infection size in the highest-risk patch since it exports more infections than it imports, but this consequently increases infections in the patch with the lowest risk. However, it is never possible for the highest-risk patch to have the lowest disease prevalence.<\/p>\n

Using a numerical simulation based on the common cold\u2014the attributes of which are well-studied\u2014Gao delved deeper into human migration’s impact on the total size of an infection. When Gao incorporated just two patches, his model exhibited a wide variety of behaviors under different environmental conditions. For example, the dispersal of humans often led to a larger total infection size than no dispersal, but rapid human scattering in one scenario actually reduced the infection size. Under different conditions, small dispersal was detrimental but large dispersal ultimately proved beneficial to disease management. Gao completely classifies the combinations of mathematical parameters for which dispersal causes more infections when compared to a lack of dispersal in a two-patch environment. However, the situation becomes more complex if the model incorporates more than two patches.<\/p>\n

Further investigation into Gao’s SIS patch modeling approach could reveal more nuanced information about the complexities of travel restrictions’ impact on disease spread, which is relevant to real-world situations\u2014such as border closures during the COVID-19 pandemic. “To my knowledge, this is possibly the first theoretical work on the influence of human movement on the total number of infections and their distribution,” Gao said. “There are numerous directions to improve and extend the current work.” For example, future work could explore the outcome of a ban on only some travel routes, such as when the U.S. banned travel from China to impede the spread of COVID-19 but failed to block incoming cases from Europe. Continuing research on these complicated effects may help health agencies and governments develop informed measures to control dangerous diseases.<\/p>\n\n

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Mathematical models with complicated dynamics for disease study\n <\/p><\/div>\n

\n More information:<\/strong>
\n Gao, Daozhou. How does dispersal affect the infection size? SIAM J. Appl. Math.<\/i> (2020).<\/p>\n
\n Provided by
\n Society for Industrial and Applied Mathematics
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Citation<\/strong>:
\n The impact of human mobility on disease spread (2020, September 22)
\n retrieved 22 September 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-09-impact-human-mobility-disease.html<\/p>\n

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