{"id":802,"date":"2020-06-03T21:04:00","date_gmt":"2020-06-03T18:04:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/tiny-human-livers-successfully-grown-in-lab-have-been-transplanted-into-rats\/"},"modified":"2020-06-03T21:04:00","modified_gmt":"2020-06-03T18:04:00","slug":"tiny-human-livers-successfully-grown-in-lab-have-been-transplanted-into-rats","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/tiny-human-livers-successfully-grown-in-lab-have-been-transplanted-into-rats\/","title":{"rendered":"#Tiny human livers successfully grown in lab have been transplanted into rats"},"content":{"rendered":"

“Tiny human livers successfully grown in lab have been transplanted into rats<\/strong>”<\/p>\n

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June 3, 2020 |<\/span> 2:04pm <\/p>\n

\n Enlarge Image<\/p>\n

\"Tiny<\/img>
\n Miniature liver made from human skin cells turned stem cells turned specialized liver cells.<\/span>
\n UPMC \/SWNS<\/span><\/p><\/div>\n

\n Miniature human livers have been successfully grown in a lab by scientists \u2013 who then transplanted them into rats. <\/p>\n

Human volunteers donated skin cells which researchers then developed into fully-functional mini-livers in a laboratory.<\/p>\n

Livers take up to two years to mature naturally, but the researchers managed to engineer similar results in under a month.<\/p>\n

Researchers hope that their new technique might be a step towards one day replacing organ donation.<\/p>\n

Study senior author Dr. Alejandro Soto-Gutierrez, at Pittsburgh University, said: \u201cSeeing that little human organ there inside the animal \u2013 brown, looking like a liver \u2013 that was pretty cool.<\/p>\n

\u201cThis thing that looks like a liver and functions like a liver came from somebody\u2019s skin cells.\u201d<\/p>\n

\"This<\/img>
This rat received a transplanted lab-grown miniature liver.<\/span>UPMC\/SWNS<\/span><\/figcaption><\/figure>\n

The \u201cmade-to-order\u201d livers secrete bile acids and urea just like their natural equivalents, the team explained.<\/p>\n

The researchers created their mini livers by reprogramming human skin cells into different types of liver stem cells.<\/p>\n

Then they seeded those human liver cells into a rat liver which had been strip<\/a>ped of its own cells.<\/p>\n

As the ultimate test, the researchers transplanted their mini livers into five rats, which had been specially bred to resist organ rejection.<\/p>\n

Four days after the transplant, researchers investigated how the implanted organs were faring.<\/p>\n

Blood flow problems had developed within and around the graft, but the rats had human liver proteins in their blood serum proving that the transplants had worked.<\/p>\n

The team is optimistic that their research is not merely a stepping-stone towards growing replacement organs in a lab, but also a useful tool in its own right.<\/p>\n

Dr. Soto-Gutierrez, a pathology specialist, added: \u201cThe long-term goal is to create organs that can replace organ donation, but in the near future, I see this as a bridge to transplant.<\/p>\n

\u201cFor instance, in acute liver failure, you might just need hepatic boost for a while instead of a whole new liver.\u201d<\/p>\n

But he conceded that there are significant challenges to overcome, including the organs\u2019 long-term survival and several safety issues.<\/p>\n

The study results were published in the journal Cell Reports.\n <\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n

Source<\/a><\/span><\/p>\n

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If you want to read more Technology<\/a> News<\/a> articles, you can visit our Technology category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n

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“Tiny human livers successfully grown in lab have been transplanted into rats” June 3, 2020 | 2:04pm Enlarge Image Miniature liver made from human skin cells turned stem cells turned specialized liver cells. UPMC \/SWNS Miniature human livers have been successfully grown in a lab by scientists \u2013 who then transplanted them into rats. Human…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[18],"tags":[1350],"class_list":["post-802","post","type-post","status-publish","format-standard","hentry","category-technology","tag-tiny-human-livers-successfully-grown-in-lab-have-been-transplanted-into-rats"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=802"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/802\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}