{"id":90358,"date":"2020-10-15T22:06:59","date_gmt":"2020-10-15T19:06:59","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/all-terrain-microrobot-flips-through-a-live-colon\/"},"modified":"2020-10-15T22:06:59","modified_gmt":"2020-10-15T19:06:59","slug":"all-terrain-microrobot-flips-through-a-live-colon","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/all-terrain-microrobot-flips-through-a-live-colon\/","title":{"rendered":"#All-terrain microrobot flips through a live colon"},"content":{"rendered":"<p>&#8220;<strong>#All-terrain microrobot flips through a live colon<\/strong>&#8221;<\/p>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2020\/allterrainmi.gif\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2020\/allterrainmi.gif\" data-sub-html=\"Live ultrasound footage shows a microrobot tumbling through a colon in vivo. Credit: Purdue University video\/Elizabeth Niedert and Chenghao Bi\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2020\/allterrainmi.gif\" alt=\"All-terrain microrobot flips through a live colon\" title=\"Live ultrasound footage shows a microrobot tumbling through a colon in vivo. Credit: Purdue University video\/Elizabeth Niedert and Chenghao Bi\" width=\"600\" height=\"338\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Live ultrasound footage shows a microrobot tumbling through a colon in vivo. Credit: Purdue University video\/Elizabeth Niedert and Chenghao Bi<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A rectangular robot as tiny as a few human hairs can <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/trip-and-travel\/\" data-internallinksmanager029f6b8e52c=\"10\" title=\"Trip &amp; Travel\" target=\"_blank\" rel=\"noopener\">travel<\/a> throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models.<\/p>\n<p>                                                                                Why the back flips? Because the goal is to use these robots to transport drugs in humans, whose colons and other organs have rough terrain. Side flips work, too.<\/p>\n<p>Why a back-flipping robot to transport drugs? Getting a drug directly to its target site could remove side effects, such as hair loss or stomach bleeding, that the drug may otherwise cause by interacting with other organs along the way.<\/p>\n<p>The study, published in the journal <i>Micromachines<\/i>, is the first demonstration of a microrobot tumbling through a biological system in vivo. Since it is too small to carry a battery, the microrobot is powered and wirelessly controlled from the outside by a magnetic field.<\/p>\n<p>&#8220;When we <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ly a rotating external magnetic field to these robots, they rotate just like a car tire would to go over rough terrain,&#8221; said David Cappelleri, a Purdue associate professor of mechanical engineering. &#8220;The magnetic field also safely penetrates different types of mediums, which is important for using these robots in the human body.&#8221;<\/p>\n<p>The researchers chose the colon for in vivo experiments because it has an easy point of entry\u2014and it&#8217;s very messy.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\"><meta itemprop=\"name\" content=\"All-terrain microrobot flips through a live colon\"\/><meta itemprop=\"url\" content=\"https:\/\/youtu.be\/9OsYpJFWnN8\"\/><meta itemprop=\"description\" content=\"Tumbling Magnetic Microrobots In Vivo. Credit: Purdue University Mechanical Engineering\"\/><meta itemprop=\"uploadDate\" content=\"2020-10-15T14:50:50-04:00\"\/><meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/9OsYpJFWnN8\"\/><meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/9OsYpJFWnN8\/maxresdefault.jpg\"\/><br \/>\n             <iframe loading=\"lazy\" title=\"Tumbling Magnetic Microrobots In Vivo\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/9OsYpJFWnN8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">Tumbling Magnetic Microrobots In Vivo. Credit: Purdue University Mechanical Engineering<\/figcaption><\/figure>\n<p>&#8220;Moving a robot around the colon is like using the people-walker at an airport to get to a terminal faster. Not only is the floor moving, but also the people around you,&#8221; said Luis Solorio, an assistant professor in Purdue&#8217;s Weldon School of Biomedical Engineering.<\/p>\n<p>&#8220;In the colon, you have all these fluids and materials that are following along the path, but the robot is moving in the opposite direction. It&#8217;s just not an easy voyage.&#8221;<\/p>\n<p>But this magnetic microrobot can successfully tumble throughout the colon despite these rough conditions, the researchers&#8217; experiments showed. <\/p>\n<p>The team conducted the in vivo experiments in the colons of live mice under anesthesia, inserting the microrobot in a saline solution through the rectum. They used ultrasound equipment to observe in real time how well the microrobot moved around.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>The microrobots could also tumble in colons excised from pigs, the researchers found, which have similar guts to humans.<\/p>\n<p>&#8220;Moving up to large animals or humans may require dozens of robots, but that also means you can target multiple sites with multiple drug payloads,&#8221; said Craig Goergen, Purdue&#8217;s Leslie A. Geddes Associate Professor of Biomedical Engineering, whose research group led work on imaging the microrobot through various kinds of tissue.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2020\/allterrainmi.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2020\/allterrainmi.jpg\" data-sub-html=\"The microrobot can be seen just to the right of the \u201cU\u201d in United States on this U.S. penny. Credit: Purdue University image\/Georges Adam\">\n<figure class=\"article-img text-center\"><img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2020\/allterrainmi.jpg\" alt=\"All-terrain microrobot flips through a live colon\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                The microrobot can be seen just to the right of the \u201cU\u201d in United States on this U.S. penny. Credit: Purdue University image\/Georges Adam<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Solorio&#8217;s lab tested the microrobot&#8217;s ability to carry and release a drug payload in a vial of saline. The researchers coated the microrobot with a fluorescent mock drug, which the microrobot successfully carried throughout the solution in a tumbling motion before the payload slowly diffused from its body an hour later.<\/p>\n<p>&#8220;We were able to get a nice, controlled release of the drug payload. This means that we could potentially steer the microrobot to a location in the body, leave it there, and then allow the drug to slowly come out. And because the microrobot has a polymer coating, the drug wouldn&#8217;t fall off before reaching a target location,&#8221; Solorio said.<\/p>\n<p>The magnetic microrobots, cheaply made of polymer and metal, are nontoxic and biocompatible, the study showed. Cappelleri&#8217;s research group designed and built each of these robots using facilities at the Birck Nano<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> Center in Purdue&#8217;s Discovery Park.<\/p>\n<p>Commonly-used roll-to-roll manufacturing machinery could potentially produce hundreds of these microrobots at once, Cappelleri said.<\/p>\n<p>The researchers believe that the microrobots could act as diagnostic tools in addition to drug delivery vehicles.<\/p>\n<p>&#8220;From a diagnostic perspective, these microrobots might prevent the need for minimally invasive colonoscopies by helping to collect tissue. Or they could deliver payloads without having to do the prep work that&#8217;s needed for traditional colonoscopies,&#8221; Goergen said.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener noreferrer\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/medicalxpress.com\/news\/2020-09-microrobots-bridge-rat-nerve-cell.html\">Microrobots used to build bridge between rat nerve cell networks<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Elizabeth E. Niedert et al, A Tumbling Magnetic Microrobot System for Biomedical Applications, <i>Micromachines<\/i> (2020).  <a rel=\"nofollow noopener noreferrer\" target=\"_blank\" data-doi=\"1\" href=\"http:\/\/dx.doi.org\/10.3390\/mi11090861\">DOI: 10.3390\/mi11090861<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Purdue University<br \/>\n                                                                                                        <a rel=\"nofollow noopener noreferrer\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.purdue.edu\/\"><br \/>\n                                                        <svg><use href=\"https:\/\/techx.b-cdn.net\/tmpl\/v2\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 All-terrain microrobot flips through a live colon (2020, October 15)<br \/>\n                                                 retrieved 15 October 2020<br \/>\n                                                 from https:\/\/techxplore.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2020-10-all-terrain-microrobot-flips-colon.html<\/p>\n<p>                                            This document is subject to copyright. 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The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener noreferrer\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/techxplore.com\/news\/2020-10-all-terrain-microrobot-flips-colon.html\" target=\"_blank\" rel=\"noopener noreferrer\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#All-terrain microrobot flips through a live colon&#8221; Live ultrasound footage shows a microrobot tumbling through a colon in vivo. Credit: Purdue University video\/Elizabeth Niedert and Chenghao Bi A rectangular robot as tiny as a few human hairs can travel throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":90359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2020\/allterrainmi.gif","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-90358","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/90358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=90358"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/90358\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/90359"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=90358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=90358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=90358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}