#Norovirus has two alternative capsid structures which change before infection

“#Norovirus has two alternative capsid structures which change before infection” Credit: National Institutes of Natural Sciences Human noroviruses are a major cause of gastroenteritis outbreaks worldwide. They cause approximately 200,000 deaths each year in developing countries. However, no effective vaccine or antiviral agent for noroviruses yet exists because cell culture methods to produce noroviruses are…

Read More

#Understanding the circadian clocks of individual cells

“#Understanding the circadian clocks of individual cells” Credit: CC0 Public Domain Two new studies led by UT Southwestern scientists outline how individual cells maintain their internal clocks, driven both through heritable and random means. These findings, published online May 1 in PNAS and May 27 in eLife, help explain how organisms’ circadian clocks maintain flexibility…

Read More

#Microbiome confers resistance to cholera

“#Microbiome confers resistance to cholera” Vibrio cholerae bacterium, which is responsible for causing cholera. Credit: Centers for Disease Control and Prevention Cholera can kill within hours if left untreated, and it sickens as many as 4 million people a year. In a new article in the journal Cell, researchers describe how gut bacteria helps people…

Read More

#From Jekyll to Hyde: New study pinpoints mutation that makes E. coli deadlier

“#From Jekyll to Hyde: New study pinpoints mutation that makes E. coli deadlier” Silkworms are used in infection experiments to perform experimental evolution of pathogenic bacteria. Credit: Chikara Kaito As far as humans are concerned, bacteria can be classified as either harmful, pathogenic bacteria and harmless or beneficial non-pathogenic bacteria. To develop better treatments for…

Read More

#Why bacterial toxins are ‘fascinating machines of death’

“#Why bacterial toxins are ‘fascinating machines of death’” The illustration shows an overlay of different clostridial toxins. The toxin molecules are highly similar overall, as shown in green colour, except in the receptor binding region, shown in red, which allows them to evolve new receptor preferences. Credit: Mikko Taipale, Roman Melnyk, Jean-Philippe Julien The coronavirus…

Read More