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“#Are antivitamins the new antibiotics?” Credit: CC0 Public Domain Antibiotics are among the most important discoveries of modern medicine and have saved millions of lives since the discovery of penicillin almost 100 years ago. Many diseases caused by bacterial infections—such as pneumonia, meningitis or septicemia—are successfully treated with antibiotics. However, bacteria can develop resistance to…
“#Researchers take a fresh look at the Michaelis-Menten equation” Magnus Kjærgaard (left) and Mateusz Dyla challenge one of the cornerstones of biochemistry, the Michaelis-Menten equation as they show that many enzymes in signaling pathways are independent of substrate concentration, because the substrate is physically connected to the enzyme. Credit: Mateusz Dyla Researchers from Aarhus University…
“#Studying viral outbreaks in single cells could reveal new ways to defeat them” Credit: CC0 Public Domain Many viruses, including HIV and influenza A, mutate so quickly that identifying effective vaccines or treatments is like trying to hit a moving target. A better understanding of viral propagation and evolution in single cells could help. Today,…
“#Cryo-EM study yields new clues to chicken pox infection” Images extracted from cryo-EM data (left and right panels) show the varicella zoster virus’s gB protein with three antibodies attached at the ends. Different views of the protein and antibodies together were used to reconstruct their molecular structure to nearly atomic resolution. Credit: Greg Stewart/SLAC National…
“#Enzyme cocktail developed in Brazil powers production of second-generation ethanol” Trichoderma reesei fungus RUT-C30 strain, which was engineered to produce high-yield enzymes. Credit: LNBR-CNPEM Researchers at the Brazilian Center for Research in Energy and Materials (CNPEM) have genetically engineered a fungus to produce a cocktail of enzymes that break down the carbohydrates in biomass, such…
“#Designer bacteria produce coral antibiotic” Horn corals of the species Antillogorgia elisabethae produce antibiotic natural substances. A research team at TUM has successfully produced one of these substances in the laboratory. Credit: Thomas Brück/TUM Thomas Brück saw the sea whip Antillogorgia elisabethae for the first time 17 years ago while diving on a research trip…
“#Targeting iron uptake to create a new class of antibiotics against UTIs” Escherichia coli. Credit: Rocky Mountain Laboratories, NIAID, NIH At 11 million cases annually, urinary tract infections (UTIs) are the most common outpatient infections in the U.S., according to the U.S. Department of Health and Human Services. At least half of all women will…
“#Researchers use supercomputer to gain insights into hepatitis B” Electron micrograph of hepatitis B virus. Credit: Centers for Disease Control and Prevention Researchers at the University of Delaware, using supercomputing resources and collaborating with scientists at Indiana University, have gained new understanding of the virus that causes hepatitis B and the “spiky ball” that encloses…
“#Understanding the surface chemistry of SARS-CoV-2” Colorized scanning electron micrograph of a cell (blue) heavily infected with SARS-CoV-2 virus particles (red), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Better understanding of the surface chemistry of the SARS-CoV-2 virus is needed to reduce…
“#Enzyme discovered in the gut could lead to new disease biomarker” Credit: CC0 Public Domain Enzymes used by bacteria to break down mucus in the gut could provide a useful biomarker for intestinal diseases, according to new research published in Nature Communications. Researchers at the University of Birmingham and Newcastle University have successfully identified and…