Biochemistry – Page 5 – En.BuradaBiliyorum.Com

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#Drug discovery: First rational strategy to find molecular glue degraders

Admin6 years ago09 mins

“#Drug discovery: First rational strategy to find molecular glue degraders” by CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences </p><div> <div> <div data-src=”https://scx2.b-cdn.net/gfx/news/hires/2020/1-drugdiscover.jpg” data-sub-html=”Cellular viability screens nominated potential molecular glues. Orthogonal investigation of the leading molecules (dCeMM1/2/3/4) enabled the characterization of novel molecular glue degraders that recruit two different E3 ligases…

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#Iron-mediated cancer cell activity: A new regulation mechanism

Admin6 years ago05 mins

“#Iron-mediated cancer cell activity: A new regulation mechanism” Mesenchymal stem cells (on the right) are associated with metastatic dissemination, resistance to conventional chemotherapy and to relapses. During the transition to this state, the protein CD44 takes over from transferrin and its TfR1 receptor and ensures the majority of the iron endocytosis. This leads to a…

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#Chemists craft molecular scalpels to clear unwanted proteins from cell surfaces

Admin6 years ago010 mins

“#Chemists craft molecular scalpels to clear unwanted proteins from cell surfaces” EGFR, a protein important in helping cancers grow, shown here in purple, decorates the cell surface (left). After treatment with an EGFR-targeting LYTAC, all the EGFR protein is shuttled into lysosomes, the degradation compartments within the cell (right). Credit: Steven Banik When scientists find…

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#Metal-breathing bacteria could transform electronics, biosensors, and more

Admin6 years ago06 mins

“#Metal-breathing bacteria could transform electronics, biosensors, and more” Credit: Rensselaer Polytechnic Institute When the Shewanella oneidensis bacterium “breathes” in certain metal and sulfur compounds anaerobically, the way an aerobic organism would process oxygen, it produces materials that could be used to enhance electronics, electrochemical energy storage, and drug-delivery devices. The ability of this bacterium to…

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#S-glutathionylation of human-inducible Hsp70 reveals regulatory mechanism involving C-terminal α-helical lid

Admin6 years ago06 mins

“#S-glutathionylation of human-inducible Hsp70 reveals regulatory mechanism involving C-terminal α-helical lid” Figure: Under oxidative stress conditions, the molecular chaperone Hsp70 undergoes post-translational modification of cysteine residues by addition of the tripeptide glutathione. Glutathionylation within the substrate-binding domain of Hsp70 causes the C-terminal helical region of Hsp70 to unravel and occupy its own substrate binding site….

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#A new directed evolution technique to unlock the potential of xeno-nucleic acids

Admin6 years ago07 mins

“#A new directed evolution technique to unlock the potential of xeno-nucleic acids” Diagram showing the reverse transcriptase structure (white) with nascent cDNA strand (red), XNA template (green) and regions critical for reverse transcription of XNA templates (blue and purple). Credit: MRC Laboratory of Molecular Biology As well as being required for some of the core…

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#A chemical tailor-made suit for Alzheimer’s drugs

Admin6 years ago05 mins

“#A chemical tailor-made suit for Alzheimer’s drugs” Protein crystals of the human enzyme glutaminyl cyclase and atomic structure of the new inhibitor. Credit: Lisa-Marie Funk With over 1.2 million people affected in Germany alone and over 50 million people worldwide, Alzheimer’s disease, also referred to simply as Alzheimer’s, is one of the greatest medical and…

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#New substance library to accelerate the search for active compounds

Admin6 years ago07 mins

“#New substance library to accelerate the search for active compounds” For the study, the enzyme endothiapepsin (gray) was combined with molecules from the fragment library. The analysis shows that numerous substances are able to dock to the enzyme (blue and orange molecules). Every substance found is a potential starting point for the development of larger…

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#Discovery of a novel drug candidate to develop effective treatments for brain disorders

Admin6 years ago08 mins

“#Discovery of a novel drug candidate to develop effective treatments for brain disorders” The Protein NKCC1 is a transporter of ions in the brain; their concentration is crucial for brain function. The newly discovered compounds can potently and selectively block NKCC1, without undesired side effects. Credit: IIT-Istituto Italiano di Tecnologia Researchers at IIT-Istituto Italiano di…

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#Researchers solve a 50-year-old enzyme mystery

Admin6 years ago05 mins

“#Researchers solve a 50-year-old enzyme mystery” Credit: The University of Queensland Advanced herbicides and treatments for infection may result from the unraveling of a 50-year-old mystery by University of Queensland researchers. The research team, led by UQ’s Professor Luke Guddat, revealed the complete three-dimensional structure of an enzyme, providing the first step in the biosynthesis…