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“#A new discovery in pluripotent stem cells and induced regenerative medicine” In vitro culture of induced trophoblast stem cells (pink) wrapping clusters of naive induced pluripotent stem cells (cyan). Credit: Xiaodong Liu, Jia Tan and Monika Mohenska An international collaboration involving Duke-NUS Medical School and Monash University researchers has made an unexpected world-first stem cell…
“#Tiny protein motor fuels bacterial movement” The MotB protein (green) is anchored to the cell wall, and is surrounded by MotA proteins (orange), which, upon dispersion of the ion motive force, rotates around MotB. The rotation of MotA in turn powers rotation of the large bacteria motor. Credit: Dan W. Nowakowski, N Molecular Systems, Inc….
“#How dividing cells avoid setting off false virus alarms” Credit: CC0 Public Domain One feature of cell division has long puzzled scientists. The nucleus briefly disappears, leaving the cell’s DNA exposed. Normally, bare DNA indicates a viral infection and triggers enzymatic alarms that alert the immune system to the rogue DNA. But no such alarms…
“#Mechanism discovered how the coronavirus hijacks the cell” Coronaviruses replicate in a cell. On the right are complete viruses. Credit: David S. Goodsell, RCSB Protein Data Bank Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the corona virus manipulates human cells to ensure its own replication. This knowledge…
“#Add human-genome produced RNA to the list of cell surface molecules” (Left) A hypothetical model of the relative positions of FISH probes (red arrowheads) on a membrane-bound RNA fragment. (Right) A single molecule RNA fluorescence in situ hybridization image of maxRNAs (yellow arrows). Credit: Zhong Lab Bioengineers at UC San Diego have shown that human-genome…
“#Caffeine shot delivers wakeup call on antifungal drug resistance” Credit: CC0 Public Domain The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs. It was previously thought that only mutations in a fungi’s DNA would result in antifungal drug resistance. Current diagnostic…
“#Researchers solve decades old mitochondrial mystery that could lead to new disease treatments” Credit: CC0 Public Domain Penn Medicine researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer. Reporting in a…
“#Blood breakdown product commandeers important enzyme” from the Pharmaceutical Institute, University of Bonn, next to the homology model of APC with the heme-binding sites (green). Credit: (c) Barbara Frommann/Uni Bonn The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, heme is produced,…
“#Scientists reveal key steps in the formation of the recycling centers of the cell” An Atg9 vesicle serves as a platform for the recruitment of the autophagic machinery. It thereby forms a seed for the formation of an autophagosome around the cargo by accepting lipids that are transferred by the Atg2 protein from the neighbouring…
“#How to remove unwanted components from the cell nucleus” This fluorescence image shows a dividing cell with segregated chromosomes (magenta) that are tightly clustered at the cell poles by the protein Ki-67 (green). Credit: Sara Cuylen-Häring/EMBL The organization of cells into specific compartments is critical for their function. For instance, by separating the nucleus from…