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“#Structural biology reveals new target to neutralize COVID-19” One of the five Titan Krios cryo-electron microscopes used at eBIC for both single particle analysis and cryo-tomography at Diamond Light Source for the work on this paper. Credit: Diamond Light Source Ltd An international team of researchers have discovered a new and highly conserved site on…
“#Locating and severing lethal links in DNA” Credit: Pixabay/CC0 Public Domain Chemical lesions in the genetic material DNA can have catastrophic consequences for cells, and even for the organism concerned. This explains why the efficient identification and rapid repair of DNA damage is vital for survival. DNA-protein crosslinks (DPCs), which are formed when proteins are…
“#Decoded: The structure of the barrier between three cells” Credit: Unsplash/CC0 Public Domain Organs in animals and in humans have one thing in common: they are bounded by so-called epithelial cells. These, along with the muscle, connective and nervous tissues, belong to the basic types of tissue. Epithelial cells form special connections with one another…
“#A protein with an unprecedented fold helps bacteria uptake thiosulfate as a sulfur source” Credit: Unsplash/CC0 Public Domain A new study led by researchers at Nara Institute of Science and Technology (NAIST), Nara, Japan, published in Science Advances, reports the crystal structure of YeeE, a membrane protein that allows bacteria to uptake thiosulfate from the…
“#A ribosome odyssey in mitochondria” Credit: Science For Life Laboratory Proteins make life and are made by ribosomes. In mitochondria, the repertoire of the mitoribosomal architectures turns out to be much more diverse than previously thought. A paper published in eLife by Alexey Amunts lab reports extraction of the mitoribosome from a ciliated protozoan and…
“#Uncontrolled molecule sparks rare liver cancer” The small molecule cAMP gets stuck in the crowded R1a bodies. Credit: Jin Zhang, UC San Diego Since humans first controlled fire, they have camped around it to circulate information, signaling each other when something approaches. Metaphorically, certain molecules have been carrying information around our cells to help regulate…
“#Researchers discover a new way cells can dispose of misfolded proteins” Credit: Brain sections of wild-type (normal, left) and Ngly1-deficient (right) murine embryos. When the Ngly1-mediated mechanism for disposing of misfolded BMP signaling proteins fails (right panel), brain development can be dramatically affected. The structure in the middle of each panel is the choroid plexus…
“#Enzyme prisons: Cell signaling with just one molecule” The confocal image shows cells expressing one of the newly designed nanorulers to map nanometer-size cAMP gradients in intact cells. Credit: Paolo Annibale, MDC A team at the Max Dellbruck Center has answered a question that has puzzled scientists for some 40 years. In the journal Cell,…
“#Study revealing structure of a protein complex may open doors to better disease research” An artistic representation of the Arp2/3 complex structure in an inactive state (top left) and active state with nucleated filament (bottom right). With a cryo-EM micrograph as the background it shows actin filaments nucleated from the Arp2/3 complex. Credit: Stony Brook…
“#Each human gut has a viral ‘fingerprint’” Credit: CC0 Public Domain Each person’s gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system. An analysis of viruses in the guts of healthy Westerners also showed that dips and…