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“#Replicating a genome starts with a twist, a pinch, and a bit of a dance” The Origin of Replication Complex (ORC) is a structure that binds to DNA and starts the genome duplication process as a cell gets ready to divide. In this model of human ORC, the almost donut-shaped complex clamps down on DNA…
“#Gene-edited livestock ‘surrogate sires’ successfully made fertile” A gene-edited surrogate bull. Credit: Bob Hubner, Washington State University For the first time, scientists have created pigs, goats and cattle that can serve as viable “surrogate sires,” male animals that produce sperm carrying only the genetic traits of donor animals. The advance, published in the Proceedings of…
“#Are male genes from Mars, female genes from Venus? Review highlights sex differences in health and disease” Wilson is a researcher in the Biodesign Center for Mechanisms in Evolution, the Center for Evolution and Medicine, and ASU’s School of Life Sciences. Credit: The Biodesign Institute at Arizona State University Males and females share the vast…
“#Mutant tomato helps to crack the secrets of fruiting” Credit: Pixabay/CC0 Public Domain It may sound like something out of a science fiction B-movie, but with the help of a mutant tomato, researchers from Japan have discovered that the development process of fruit rewires their central metabolism pathway. In a study published this month in…
“#Prediction of protein disorder from amino acid sequence” Credit: Unsplash/CC0 Public Domain Structural disorder is vital for proteins’ function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. Researchers from Aarhus University have developed a prediction tool by using machine…
“#Machine learning aids gene activation discovery” UC San Diego scientists have solved a long-standing puzzle in human gene activation. The discovery described in the journal Nature could be used to control gene activation in biotechnology and biomedical applications. Credit: Kadonaga Lab, UC San Diego Scientists have long known that human genes spring into action through…
“#Through enzyme testing, researchers sharpen CRISPR gene-editing tool” Credit: CC0 Public Domain One of the biggest scientific advances of the last decade is getting better thanks to researchers at The University of Texas at Austin; the University of California, Berkeley; and Korea University. The team has developed a new tool to help scientists choose the…
“#The birth of a male sex chromosome in Atlantic herring” Credit: Pixabay/CC0 Public Domain The evolution of sex chromosomes is of crucial importance in biology as it stabilizes the mechanism underlying sex determination and usually results in an equal sex ratio. An international team of scientists, led by researchers from Uppsala University, now reports that…
“#Genetic study of proteins is a breakthrough in drug development for complex diseases” Comparing the genetic inferred causal relationships of proteins on human diseases with historic drug development programs, this study, for the first time, showed that protein-disease pairs with genetic predicted causal evidence is more likely to be approved drugs for the same indications….
“#Researchers find conserved regeneration-responsive enhancers linked to tail regeneration in fish” Credit: CC0 Public Domain A team of researchers from Stowers Institute for Medical Research, Howard Hughes Medical Institute and Stanford University has discovered conserved regeneration-responsive enhancers linked to tail regeneration in fish common to two species. In their paper published the journal Science, the…