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“#A race to solve the COVID protein puzzle” This transmission electron microscope image shows SARS-CoV-2 — also known as 2019-nCoV, the virus that causes COVID-19 — isolated from a patient in the US. Virus particles are shown emerging from the surface of cells cultured in the lab. The spikes on the outer edge of the…
“#Bubbling and burping droplets of DNA” Surprising behavior: Enzymes can cause DNA droplets to suddenly start to bubble and look like boiling water. Credit: Ludwig Maximilian University of Munich Liquid droplets formed from DNA display a peculiar response to enzymes. An international collaboration between LMU and UCSB has now been able to explain the mechanisms…
“#New technique allows scientists to measure mitochondrial respiration in frozen tissue” Left to right: Study authors Linsey Stiles, Dr. Orian Shirihai and Rebeca Acin-Perez. Credit: Shirihai Lab/UCLA Scientists led by Dr. Orian Shirihai, director of the metabolism theme at the David Geffen School of Medicine at UCLA, have developed a method for restoring oxygen-consumption activity…
“#Experimental peptide targets COVID-19” Colorized scanning electron micrograph of an apoptotic cell (pink) heavily infected with SARS-COV-2 virus particles (green). MIT researchers are using computational models of protein interactions to design a peptide that can bind to coronavirus proteins and shuttle them into a cellular pathway that breaks them down. Credit: National Institute of Allergy…
“#Studying cells in reduced dimensions” A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia Single-cell RNA sequencing is a powerful tool for identifying transcriptomic variations and developmental trajectories in cell types…
“#Which came first? An experiment in reconstructing primordial proteins solves a long-standing riddle” The characteristic (HhH)2 fold and its binding to the minor groove of a modern DNA molecule. How did the first ones form? Credit: Weizmann Institute of Science What did the very first proteins look like—those that appeared on Earth around 3.7 billion…
“#Viruses can steal our genetic code to create new human-virus genes” Credit: Unsplash/CC0 Public Domain Like a scene out of “Invasion of the Body Snatchers,” a virus infects a host and converts it into a factory for making more copies of itself. Now researchers have shown that a large group of viruses, including the influenza…
“#Researchers map out intricate processes that activate key brain molecule” An image of GABA-B components GB1 (blue) and GB2 (yellow). Credit: Cornelius Gati/SLAC National Accelerator Laboratory For researchers looking to understand and someday treat certain neuropsychological ailments, one place to start is a molecule known as GABA, which binds to receptor molecules in neurons and…
“#Simulated sea slug gets addicted to drug” The simulated sea slug, ASIMOV, monitors its own internal state and makes decisions about what to consume. Its options are: a tasty and nutritious food (blue), a nutritious food that comes with a painful sting (green), and an intoxicating drug that has no nutritious value (yellow). Credit: Tracy…