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“#Researchers find clues to clarify why cohesine has a role in cancer and cardiac development” Transversal sections of wild type (WT) and STAG2 knock out (KO) murine embryos at day 9.5 of gestation stained with antibodies against STAG2 (top) or hematoxilin-eosin (H.E, bottom) reveal the smaller size and the malformation of hearts developed in the…
“#Protein uses two antiviral strategies to ward off infections” Credit: Unsplash/CC0 Public Domain To protect humans against infection, a protein called MARCH8 tags the vesicular stomatitis virus (VSV) for destruction while it merely holds HIV hostage, a new study in eLife shows. The findings reveal how a single protein can use multiple strategies to defend…
“#Modelling parasitic worm metabolism suggests strategy for developing new drugs against infection” Credit: Unsplash/CC0 Public Domain Scientists have revealed a way to eradicate parasitic worms by stopping them from using alternative metabolism pathways provided by bacteria that live within them, according to new findings published today in eLife. The study has identified three potential drugs…
“#The structural basis of focal adhesion kinase activation on lipid membranes unravelled” Assembly of oligomeric FAK (yellow/cyan) on the membrane (purple) triggers autophosphosphorylation. Shown is a state where the autophosphorylation site (red glow) is bound to the active site of the FAK kinase. Credit: CIB-CSIC A research team led by Daniel Lietha has just published…
“#Imaging method highlights new role for cellular ‘skeleton’ protein” A cancer cell labeled for actin (red) and mitochondria (cyan). The scientists designed novel probes that specifically monitor interactions between actin and mitochondria. Credit: Salk Institute/Waitt Advanced Biophotonics Center While your skeleton helps your body to move, fine skeleton-like filaments within your cells likewise help cellular…
“#Lead poisoning could reduce gene expression in humans” A line map of Kabwe, indicating the mine dump (red dashes) and the townships involved in the study (black and green ovals). Credit: Yared B. Yohannes et al., Environmental Research, June 05, 2020 Scientists have unveiled a correlation between high blood lead levels in children and methylation…
“#Fine-tuning metabolic gene expression to identify variants in yeast genes” Gradient of the betaxanthins production in yeast across various different cultures. Credit: Matthew Deaner Scientists have developed a more nuanced library approach to tuning gene expression in metabolic pathways. Compared to the traditional way, which leverages an all-or-nothing approach to expression, scientists can now opt…
“#World film premiere: Death of cell infected with tuberculosis” Credit: Norwegian University of Science and Technology Professor Trude Helen Flo says that the tuberculosis bacterium hides in the very cells that are actually supposed to kill it. The research team filmed the infection in several 24-hour sequences. Credit: Geir Mogen/NTNU The tuberculosis bacterium has been…
“#How growth rates influence the fitness of bacteria” First author Elena Biselli, PhD student at the TUM Department of Physics, at the microscope. Credit: Andreas Heddergott/TUM Bacteria are survival artists: When they get nutrition, they multiply rapidly, albeit they can also survive periods of hunger. But, when they grow too quickly, their ability to survive…
“#Scientists discover new concept of bacterial gene regulation” Microbiologist Kai Papenfort from the University of Jena (Germany). Credit: Anne Günther/University Jena Bacteria are always with us: These tiny organisms are found within and on our body as is the case with all animals and plants. As part of a healthy microbiome they ensure our wellbeing….